CryoEM structure of a transmembrane protein

nsp13-2 bound with RNA(local map of pre-CI RTC)

The structure of RNA polymerase II elongation complex paused at N-2 state by actinomycin D.

High resolution Cryo-EM structure of human complex I in mitochondria

High resolution cryo-EM structure of human complex III in mitochondria

Bacillus subtilis endospore crust protein CgeA

Cryo-EM structure of Arabidopsis thaliana H2A-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C1 symmetry)

Bacterial 30S ribosomal subunit assembly complex state B (Consensus Refinement)

Structure of the Bacterial Ribosome with hypoxia-induced rRNA modifications

Structure of the Bacterial Ribosome without hypoxia-induced rRNA modifications

CRP-HCAb2 complex

The cryo-EM structure of Ac-E57A_G51DA53T a-syn fibril.

The cryo-EM structure of MSA-like fold (P1) formed under the palette stratagy.

Cryo-EM structure of Arabidopsis thaliana H2A.Z-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C2 symmetry)

Cryo-EM structure of Arabidopsis thaliana H2A.W-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C1 symmetry)

The cryo-EM structure of Ac-K58D_G51DA53T a-syn fibril.

Cryo-EM structure of Arabidopsis thaliana H2A.W-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C2 symmetry)

Cryo-EM structure of AbCapV S58A filament bound with 3'3'-cGAMP with extra phospholipid density

Cryo-EM structure of Arabidopsis thaliana H2A-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C2 symmetry)

Cryo-EM structure of Arabidopsis thaliana H2A.Z-H3.3-nucleosome with Arabidopsis native 147bp DNA 15.2.2 (C1 symmetry)

Cryo-EM structure of RNF168'-RNF168-UbcH5c complex bound to nucleosome

Cryo-EM structure of the L. garvieae Man-PTS

Cryo-EM structure of the L. garvieae Man-PTS in complex with the bacteriocin GarQ

Cryo-EM structure of the GarQ-lmYZ complex

State 2 MAP 1 SETD2 bound to proximal H3 of upstream nucleosome

The Cryo-EM structure of bacterial beta-1,3-glucan phosphorylase from family GH161

a5b3 GABAA Receptor resting state

A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery

State 1 MAP3 RNA Pol II activated elongation complex with SETD2 and upstream hexasome

Cryo-EM structure of Chaetomium thermophilum ribosome-bound SND3 translocon

Apo form of the L protein from Rift Valley Fever Virus

Catalase CryoEM Structure from Human erythrocyte at 1.87A resolution

Composite map of the A. thaliana nuclera pore complex

Cryo-EM structure of photosystem II C2S2M2L2 supercomplex from the green alga Chlorella ohadii

Catalase CryoEM Structure from Rhizobium radiobacter at 1.7A resolution

Inactive-state naloxone-mu opioid receptor nanobody6 complex - Locally refined receptor map

Latent-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi map

Unlatched-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound)

Engaged-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound)

Nucleotide-free naloxone-mu opioid receptor Gi1 complex - Locally refined receptor map

Nucleotide-free naloxone-mu opioid receptor Gi1 complex - Consensus map

Cryo-EM structure of Csm/AcrIIIA2/enolase 4:3 complex

Nucleotide-free naloxone-mu opioid receptor Gi1 complex - Locally refined Gi map

Inactive-state naloxone-mu opioid receptor nanobody6 complex - Consensus map

Cryo-EM structure of Csm/AcrIIIA2/enolase 3:2 complex

Inactive-state naloxone-mu opioid receptor nanobody6 complex - Locally refined fiducal map

Consensus map for the composite map of RpaA bound to PkaiBC DNA and Syn7942 RNAP-SigA holoenzyme

Latent-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Unlatched-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Latent-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Unlatched-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Unlatched-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi map

Primed-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Primed-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound)

Unlatched-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Primed-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Unlatched-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi map

Engaged-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi map

Latent-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound)

Unlatched-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Primed-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi map

Inactive-state naloxone-mu opioid receptor nanobody6 complex

Engaged-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Nucleotide-free naloxone-mu opioid receptor Gi1 complex

Unlatched-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound)

Engaged-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Open-AHD naloxone-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined map

Engaged-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined map

Latent-state naloxone-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined map

Engaged-state naloxone-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined map

Latent-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined map

Latent-state loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Consensus map

Latent-state loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined map

Engaged-state loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined map

Engaged-state loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Consensus map

Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S

Catalytic domain local map of extended M. sexta soluble guanylate cyclase mutant beta C122S

44.5SYsxC particles isolated from YsxC-depleted cells. Class 1.

H-NOX domain local map of ligand-free of M. sexta soluble guanylate cyclase mutant beta C122S

H-NOX domain local map of extended M. sexta soluble guanylate cyclase mutant beta C122S

Consensus map of extended state M. sexta soluble guanylate cyclase mutant beta C122S with CYR715

44.5SYsxC particles isolated from YsxC-depleted cells. Class 2.

Compact, ligand-free state of Manduca sexta soluble guanylate cyclase mutant beta C122S

44.5SYsxC particles after incubation at 37 oC for 15 min. Class 1

Extended, CYR715-bound state of Manduca sexta soluble guanylate cyclase mutant beta C122S

YsxC-GMPPNP treated 44.5SYsxC particles. Class 1.

Catalytic domain local map of ligand-free M. sexta soluble guanylate cyclase mutant beta C122S

44.5SYsxC particles after incubation at 37 oC for 15 min. Class 2.

(Apo)Alpha-synuclein fibril structures from MSA patient brain

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 4 hours

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 6 hours

CNS-11g alone fibril

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 15 hours

Complex fibril structure of MSA alpha-synuclein with CNS-11g at 10 hours

CRISPR-associated deaminase Cad1 in cA4 bound in hexamer form refined against the consensus map

HIV-1 N332-GT5 SOSIP in complex with mouse polyclonal antibodies (V3-glycan and gp41-base epitopes) following protein multi antigen prime

Cryo-EM structure of vaccine-elicited antibody T6_P_H03 in complex with HIV Env trimer Q23-APEX-GT1

CryoEM Structure of De Novo Antibody Fragment scFv 6 with C. difficile Toxin B (TcdB)

HIV-1 N332-GT5 SOSIP in complex with mouse polyclonal antibodies (V3-glycan epitope) following mRNA multi antigen prime

Active conformation of a redox-regulated glycoside hydrolase (CapGH2b) from the GH2 family

CryoEM Structure of De Novo VHH, VHH_flu_01, bound to influenza HA, strain A/USA:Iowa/1943 H1N1

44.5SYsxC particles isolated from YsxC-depleted cells. Class 3.

YsxC-GMPPNP treated 44.5SYsxC particles. Class 2.

Consensus map of ligand-free M. sexta soluble guanylate cyclase mutant beta C122S

YsxC-GTP treated 44.5SYsxC particles. Class 1.

YsxC-GMPPNP treated 44.5SYsxC particles. Class 3.

YsxC-GTP treated 44.5SYsxC particles. Class 2.

YsxC-GTP treated 44.5SYsxC particles. Class 3

YsxC-GTP treated 44.5SYsxC particles. Class 4.

YsxC-GTP treated 44.5SYsxC particles. Class 5.

44.5SYsxC particles after incubation at 37 oC for 15 min. Class 3.

Hemagglutinin CA09 homotrimer bound to AMB38310/AMB38599 Fab

Symmetry-expanded reconstruction of augmin T-II bonsai on the GTPgammaS microtubule

The cryo-EM map of Retron_Eco8 complex in Apo state

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

The structure of Retron Eco8 in Apo state

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

The structure of Retron Eco8-SSB complex

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

Structure of the S. cerevisiae clamp loader Replication Factor C (RFC) with mixed nucleotide occupancy

Cryo-EM structure of human G6PT in complex with chlorogenic acid

Cryo-EM structure of human G6PT in apo state

Cryo-EM structure of human G6PT in complex with G6P

Cryo-EM structure of the hexameric DRT4

Cryo-EM structure of the fMLFC-FPR1-Gi complex

Cryo-EM structure of the catalytically inactive DRT4

Cryo-EM structure of the substrate bound DRT4

Structural Basis for the Recognition of Blood Group Trisaccharides by Tulane virus

XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex) capping a RAD51 filament on partially duplex DNA

Cryo-EM structure of homomeric TRPC channel, class 2

Cryo-EM structure of heteromeric TRPC channel

XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex) capping a RAD51 filament on a D-loop intermediate

Cryo-EM structure of homomeric TRPC channel, class 1

Mouse otoferlin (216-1931) in complex with an MSP2N2 lipid nanodisc (30 mol% DOPS, 10 mol% PI(4,5)P2)

Structure of hemagglutinin from Asiatic toad influenza-like virus complexed with avian receptor analog LSTa

Cryo-EM structure of human sodium pump E1003 in (3Na+)E1-AMPPCP state

Cryo-EM structure of human sodium pump WT in (2K+)E2-AlF state

Cryo-EM structure of human sodium pump E1003K in (2K+)E2-AlF state

Cryo-EM structure of human sodium pump E1003K complexed with NDRG3 in (2Na+)E1 state

Cryo-EM structure of human sodium pump E1003K complexed with NDRG3 in (2Na+)E1-AMPPCP state

Cryo-EM structure of human sodium pump WT in (3Na+)E1-AMPPCP state

Cryo-EM structure of human sodium pump E1003K complexed with NDRG3 and TMX2 in (2Na+)E1-AMPPCP state

Cryo-EM structure of Chaetomium thermophilum ribosome-bound SND3 translocon complex with improved density for TRAP alpha luminal domain

Local refinement of ArpC2 in the map of Coronin-7 CA bound to Arp2/3 complex

Cryo-EM structure of the ClpXP AAA+ protease bound to lambdaO-tagged Arc in a recognition complex

Improvement of the Arp3 flexible loop in the map of Coronin-7 CA bound to Arp2/3 complex

Local refinement of ArpC3 in the map of Coronin-7 CA bound to Arp2/3 complex

Local refinement of ArpC5 in the map of Coronin-7 CA bound to Arp2/3 complex

Focused map of Csm/AcrIIIA2/enolase 4:3 complex

Sf11 capsid Icosahedral Reconstruction

Consensus map of Csm/AcrIIIA2/enolase 4:3 complex

Sf11 bacteriophage portal

Cryo-EM structure of the ClpXP AAA+ protease bound to an unidentified portion of lambdaO-tagged Arc substrate within a translocation complex

Local refinement of Arp2 in the map of Coronin-7 CA bound to Arp2/3 complex

Sf11 bacteriophage tail

Improvement of the ArpC1 extension in the map of Coronin-7 CA bound to Arp2/3 complex

Structure of the bacteriophage E1004 tail

Cryo-EM structure of the Retron-Eco7 complex (state 5)

Cryo-EM structure of the Retron-Eco7 complex (state 1)

Cryo-EM structure of the Retron-Eco7 complex (state 2)

Cryo-EM structure of the Retron-Eco7 complex (state 3)

Cryo-EM structure of the Retron-Eco7 complex (state 4)

Cryo-EM structure of spiny eel influenza-like virus HA and GM2 complex

C12 portal complex of the bacteriophage E1004

Structure of the bacteriophage E1004 capsid

Core proteins of the bacteriophage E1004

VLP structure of Chikungunya virus complexed with C34 Fab, 2f block.

Structure of the Omicron Spike RBD bound by the monobody s19382 (local refinement from dimerized Spike protein ECDs)

cryo-EM structure of broad betacoronavirus binding antibody 1871 in complex with OC43 S2 subunit

Cryo-EM map of the human TREX-2.1 complex bound to DDX39B(UAP56)

Negative stain EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 1H2

Negative stain EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 1A1

Negative stain EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 7G4

Negative stain EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 6G1

cAMP-bound WT SthK in 3:1 DOPC:POPE nanodiscs

Apo WT SthK in 3:1 DOPC:POPE nanodiscs

Cryo-EM structure of Propionyl-CoA carboxylase at 1.9 angstrom resolution from Biortus

Cryo-EM structure of 5-HT1AR-Gi3 in complex with buspirone

Cryo-EM structure of 5-HT1AR-GoA in complex with (S)-pindolol

Cryo-EM structure of 5-HT1AR-GoA in complex with buspirone

Cryo-EM structure of 5-HT1AR-Gz in complex with (R)-8-OH-DPAT

Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone

Cryo-EM structure of 5-HT1AR-Gi3 in complex with F-15599

Cryo-EM structure of 5-HT1AR-GoA in complex with TMU4142

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 3IsdH(alpha2beta):Hbtet complex

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 left tail

Cryo-EM structure of SARS-CoV2 KP.3.1.1 spike protein

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 right tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 right tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 left tail

Local refinement of NTD and RBD domains of SARS-CoV2 KP.3.1.1 spike protein

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha2):Hbtet complex - 3DVA component 0 left tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha*beta):Hbdim complex - 3DVA component 1 left tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha*beta):Hbdim complex - 3DVA component 1 right tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha*beta):Hbdim complex - 3DVA component 0 right tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 3IsdH(alphabeta2):Hbtet complex

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha2):Hbtet complex - 3DVA component 0 right tail

Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH(alpha*beta):Hbdim complex - 3DVA component 0 left tail

Symmetry relaxed asymmetric structure of an expansion intermediate of Turnip crinkle virus

In situ microtubule of EpoB-induced regenerating axons

Cryo-EM structure of the IFI16-PYD filament

Icosahedral symmetric structure of an expansion intermediate of Turnip Crinkle Virus (Asymmetric Trimer Unit)

Cryo-EM structure of the isethionate TRAP transporter IseQM from Oleidesulfovibrio alaskensis with bound isethionate

Cryo-EM structure of the lipid-bound succiante dehydrogenase from Chloroflexus aurantiacus

Cryo-EM structure of the apo-form succinate dehydrogenase from Chloroflexus aurantiacus

Cryo-EM structure of the MK4-bound succinate dehydrogenase from Chloroflexus aurantiacus

Cryo-EM structure of the MK7-bound succinate dehydrogenase from Chloroflexus aurantiacus

Respiratory Syncytial Virus pre-F trimer bound by neutralizing antibody PR306007

Cryo-EM structure of KICSTOR CCC complex (state 4)

Cryo-EM structure of KICSTOR CCC complex (state 5)

Cryo-EM structure of KICSTOR CCC complex (state 3)

Cryo-EM structure of GATOR1-KICSTOR complex

Cryo-EM structure of human full length KICSTOR complex (state 1)

Cryo-EM structure of human full length KICSTOR complex (state 2)

Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.

Cryo-EM structure of lipase/ligand complex

Cryo-EM structure of human LPHN2 (ADGRL2)/G13 complex in lipid nanodiscs

Primed-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Consensus map

Plasmodium falciparum 20S proteasome bound to inhibitor 159

Plasmodium falciparum 20S proteasome bound to inhibitor 296

Primed-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined receptor map

Primed-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined Gi GDP map

Open-AHD loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Consensus map

Primed-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound)

Open-AHD loperamide-mu opioid receptor-Gi GDP complex (constant GDP) - Locally refined receptor map

Local map(dC-RTC) of pre-CI RTC

Focus refined map of KATP core in complex with SpTx1

Focused refinement of SUR1 ABC module in complex with glibenclamide at 2.87 Angstrom

Cryo-EM structure of circular intron of thymidylate synthase (td) gene of bacteriophage T4

Cryo-EM structure of spiny eel influenza-like virus HA

nsp13-1 apo(local map of Pre-CI RTC)

nsp13-1 bound with RNA(local map of pre CI RTC)

The structure of RNA polymerase II elongation complex paused at N-1 state by actinomycin D.

The structure of 1 ACTD bound to RNA polymerase II elongation complex with 2 CTG repeats.

The structure of 2 ACTD bound to RNA polymerase II elongation complex with 3 CTG repeats

The structure of 3 ACTD bound to RNA polymerase II elongation complex with 4 CTG repeats.

Cryo-EM structure of linear intron of thymidylate synthase (td) gene of bacteriophage T4

Structure of KATP channel in complex with centipede toxin SpTx1