EMD-72725

Single-particle
3.09 Å
EMD-72725
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Deposition: 15/09/2025
Map released: 18/02/2026
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72725
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ya9 summary report (pdf.gz) Map and 9ya9 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BMS-986458 (local refined), a potent and selective BCL6 ligand directed degrader (LDD)

EMD-72725

Single-particle
3.09 Å
EMD-72725
3D View Gallery
Deposition: 15/09/2025
Map released: 18/02/2026
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ternary complex of BCL6-CRBN-DDB1 with an LDD BMS-986458
Fitted models: 9ya9

Deposition Authors: Zhu J , Fang W, Pagarigan B
Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma.
Mortensen DS , Shunatona HP , Holmberg-Douglas N , Rhodes J, Da Silva D, Gamez J, Groza M, Zhu J , Christoforou A, Johnson SA, Khambatta G , Narla RK, Nimje RY , Huang D, Dodd DS, Griffin J, Miseo G, Whitefield B, Weiss DR, Rader J, Kuzu E, Leisten J, Lai C, Shi L , Del Rosario J, Dalvie D, Rolfe M, Zapf CW, Belmont P, Alexander M , Bence N, Groocock L
(2026) J Med Chem
PUBMED: 41670385
DOI: doi:10.1021/acs.jmedchem.5c03123
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: