Groups

Proteins, structures & chemical biology

Bateman research group

Work in the Bateman research group centres on the idea that there are a finite number of families of protein and RNA genes. The group endeavours to enumerate all of these families to gain an understanding of how complex biological processes have evolved from a relatively small number of components...

Kleywegt research group

The Kleywegt research group supports the goal of the Protein Data Bank in Europe (PDBe), which is to provide integrated structural data resources that evolve with the changing needs of biologists. They endeavour to transform the structural archives by developing advanced services (e.g. PDBePISA,...

Steinbeck research group

The Steinbeck research group aims to understand how the exposome and metabolome interact. This entails the analysis of advanced multi-omics phenotypic data sets, with an emphasis on metabolomics and systems-biology-scale models. Their research has focused on structure elucidation, metabolic model...

Thornton research group

The Thornton group uses computational techniques to explore how enzymes perform catalysis, and develop novel software tools to characterise enzyme mechanisms and navigate the catalytic and substrate space. They also investigate the evolution of these enzymes to discover how they can evolve new...

Systems biology

Beltrao research group

The Beltrao group seeks to understand the function and evolution of cellular networks by exploring how genetic variability is propagated through molecules, structures and interaction networks to give rise to phenotypic variability. They collaborate with experimental groups, focusing on two areas:...

Marioni research group

The Marioni group develops effective statistical and computational methods for analysing the vast amounts of data generated in high-throughput experiments, and collaborates with experimental colleagues to apply these methods to a range of biological questions. They focus on modelling variation in...

Petsalaki research group

The Petsalaki group studies human cell signaling with the aim of creating predictive and conditional whole-cell signaling models. Using these models, we seek to gain insights into basic cell functions and disease mechanisms in order to aid the design of therapeutic approaches or biomarker...

Saez-Rodriguez research group

The Saez Rodriguez group aims to predict effective therapeutic targets. They create mathematical models that integrate a range of data (from genomic to biochemical) with sources of prior knowledge, with the aim of providing predictive power for new experiments and gaining insights into the...

Stegle research group

The Stegle group uses computational approaches to unravel the genotype--phenotype map on a genome-wide scale, developing and using statistical methodologies to dissect the causes of molecular variation. The group has shown how comprehensive modelling can greatly improve the statistical power to...

Genes & gene expression

Birney research group

The Birney research group focuses on sequence algorithms--notably theoretical and practical implementations of data compression techniques--and using intra-species variation to explore elements of basic biology. They study the interplay of natural DNA sequence variation with cellular assays and...

Brazma research group

The Brazma research group complements the Functional Genomics service team, developing new methods and algorithms and integrating new types of data across multiple platforms. The group is particularly interested in cancer genomics and transcript isoform usage, and collaborates closely with the...

Enright research group

The Enright group collaborates extensively with experimental laboratorie to predict and describe the functions of genes, proteins and regulatory RNAs as well as their interactions in living organisms. They develop algorithms, protocols and datasets for functional genomics, focusing on determining...

Flicek research group

The Flicek research group develops computational models for genome annotation and evolution-based on models incorporating DNA-protein interactions, epigenetic modifications, and the DNA sequence itself. The group is also interested in the large-scale infrastructure required for modern...

Gerstung research group

The Gerstung group develops statistical models and bioinformatics tools for understanding cause and consequence of cancer genomes. They create models for relating different layers of genomic, molecular and clinical data to extract the precise connections among variables to understand the...

Goldman research group

The Goldman group develops new evolutionary models and methods; provides these methods to other scientists via stand-alone software and web services; and applyies such techniques to biological questions of interest. The group participates in comparative genomic studies, including the analysis of...

Iqbal research group

The Iqbal group develops computational methods for representing the full breadth of genetic variation, and applies these methods to real data, for example M. tuberculosis, S. aureus, E. coli and P. falciparum. Their translational work focuses on applying whole-genome sequencing to pathogens in a...

Zerbino research group

The Zerbino group is focused on developing efficient computational methods to transform large genome-wide datasets into a map of transcriptional regulation. Using evolutionary signatures, genetic markers, epigenomic marks, and chromatin structure, we aim to derive the elusive traces of...

Finn research group

The Finn research group focuses on developing computational approaches for the reconstruction of genomes from metagenomes, thereby enriching the tree of Life. The group will also investigate the distribution of microbes and functions in different environments, and probe the functions of so-called...

Leach research group

We are interested in the development and evaluation of methodologies, tools and understanding that contribute to the discovery and development of new medicines using computer modelling and informatics methods.Some of this work builds on the widely-used ChEMBL chemogenomics resources that our...