EMD-56330
In situ cryo-ET tomogram of lysosomal structure in LLOMe-treated (0.5mM, 1h) rat hippocampal neuron.
EMD-56330
Tomography
Deposition: 12/01/2026Map released: 18/02/2026
Last modified: 18/02/2026
Sample Organism:
Rattus
Sample: Rat hippocampal neuron
Deposition Authors: Li D
,
Schwarz A ,
Wilfling F
Sample: Rat hippocampal neuron
Deposition Authors: Li D
,
Schwarz A ,
Wilfling F
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes.
Li D ,
Zhang W ,
Medina M ,
Stuke JFM ,
Schwarz A ,
Brill J,
Brenner J ,
Kraus F ,
Ohlerich S,
Lizarrondo J ,
Pflaum J ,
Grass JH ,
Soltow LM,
Hammerschmid D ,
Weber N,
Welsch S ,
Langer JD,
Windbergs M ,
Harper JW ,
Schuman E,
Hummer G ,
Grotjahn DA ,
Wilfling F
(2026) bioRxiv
,
Zhang W ,
Medina M ,
Stuke JFM ,
Schwarz A ,
Brill J,
Brenner J ,
Kraus F ,
Ohlerich S,
Lizarrondo J ,
Pflaum J ,
Grass JH ,
Soltow LM,
Hammerschmid D ,
Weber N,
Welsch S ,
Langer JD,
Windbergs M ,
Harper JW ,
Schuman E,
Hummer G ,
Grotjahn DA ,
Wilfling F
(2026) bioRxiv
Grant Support:
- Aligning Science Across Parkinsons (ASAP): ASAP-000282/ASAP-024268 (United States)