EMD-55145
Cryo-EM structure of SKM-70S ribosomal stalled complex in the rotated state with hybrid tRNAs
EMD-55145
Single-particle2.6 Å
Deposition: 24/09/2025Map released: 18/02/2026
Last modified: 18/02/2026
Sample Organism:
Escherichia coli,
Escherichia coli,
Streptococcus sanguinis
Sample: Cryo-EM structure of SKM-70S ribosomal stalled complex in the rotated state with hybrid tRNAs
Fitted models: 9sro
Deposition Authors: Morici M, Corazza M, Safdari HA, Wilson DN
Sample: Cryo-EM structure of SKM-70S ribosomal stalled complex in the rotated state with hybrid tRNAs
Fitted models: 9sro
Deposition Authors: Morici M, Corazza M, Safdari HA, Wilson DN
Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome.
Wright G 
,
Cook M,
Xu M ,
Morici M,
Travin D ,
Wang W,
Klepacki D,
Chhabra N,
Rao V,
Sahile H,
Hackenberger D,
Safdari H,
Berger M,
Corazza M,
Bond A ,
Guitor A,
Tertigas D,
Wang L,
Schaenzer A,
Ejim L,
Yarlagadda V,
Gomez J ,
Surette M ,
Av-Gay Y ,
Dhar N ,
Hung D ,
Vazquez-Laslop N ,
Mankin A ,
Wilson D
(2025) Res Sq
,
Cook M,
Xu M ,
Morici M,
Travin D ,
Wang W,
Klepacki D,
Chhabra N,
Rao V,
Sahile H,
Hackenberger D,
Safdari H,
Berger M,
Corazza M,
Bond A ,
Guitor A,
Tertigas D,
Wang L,
Schaenzer A,
Ejim L,
Yarlagadda V,
Gomez J ,
Surette M ,
Av-Gay Y ,
Dhar N ,
Hung D ,
Vazquez-Laslop N ,
Mankin A ,
Wilson D
(2025) Res Sq
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R35 GM127134 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): NIH R01 AI162961 (United States)
- Canadian Institutes of Health Research (CIHR): FDN148463 (Canada)
- German Research Foundation (DFG): WI3285/12-1 (Germany)