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Artwork by Imogen Phillips (Stephen Perse Foundation)

01 October 2020

 The protein which inspired the image for October in our 2020 calendar is a sodium-coupled leucine symporter, a prokaryotic homologue of mammalian sodium neurotransmitter symporters (NSS). The NSS proteins in mammals are responsible for clearing the synapse after a nerve signal, transporting neurotransmitters back into the axon and making it ready for another signal. The NSS proteins are common targets for anti-depressants.

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Sehnal D, Bittrich S, Velankar S, Koča J, Svobodová R, Burley SK, Rose AS.
PLoS computational biology Volume 16 (2020) p.e1008247

Puig E, Tolchard J, Riera A, Carulla N.
ACS chemical neuroscience Volume 11 (2020) p.3358-3365

Drysdale R, Cook CE, Petryszak R, Baillie-Gerritsen V, Barlow M, Gasteiger E, Gruhl F, Haas J, Lanfear J, Lopez R, Redaschi N, Stockinger H, Teixeira D, Venkatesan A, Elixir Core Data Resource Forum, Blomberg N, Durinx C, McEntyre J.
Bioinformatics (Oxford, England) Volume 36 (2020) p.2636-2642

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