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Vision - artwork displaying eyes and the rhodopsin protein

01 April 2020

The protein which inspired the image for April in our 2020 calendar is rhodopsin, the primary photoreceptor molecule in vision. Rhodopsin is a light-sensitive G-protein coupled receptor (GPCR) containing a light-absorbing chromophore, retinal. On exposure to light, rhodopsin undergoes conformational changes, initiating a signal transduction cascade. Light is then converted into an electrical signal that is transmitted to the brain, interpreted as vision.

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Sillitoe I, Andreeva A, Blundell TL, Buchan DWA, Finn RD, Gough J, Jones D, Kelley LA, Paysan-Lafosse T, Lam SD, Murzin AG, Pandurangan AP, Salazar GA, Skwark MJ, Sternberg MJE, Velankar S, Orengo C.
Nucleic acids research Volume 48 (2020) p.D314-D319

Armstrong DR, Berrisford JM, Conroy MJ, Gutmanas A, Anyango S, Choudhary P, Clark AR, Dana JM, Deshpande M, Dunlop R, Gane P, Gáborová R, Gupta D, Haslam P, Koča J, Mak L, Mir S, Mukhopadhyay A, Nadzirin N, Nair S, Paysan-Lafosse T, Pravda L, Sehnal D, Salih O, Smart O, Tolchard J, Varadi M, Svobodova-Vařeková R, Zaki H, Kleywegt GJ, Velankar S.
Nucleic acids research Volume 48 (2020) p.D335-D343

PDBe-KB consortium .
Nucleic acids research Volume 48 (2020) p.D344-D353

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