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Artwork by Imogen Phillips (Stephen Perse Foundation)

01 October 2020

 The protein which inspired the image for October in our 2020 calendar is a sodium-coupled leucine symporter, a prokaryotic homologue of mammalian sodium neurotransmitter symporters (NSS). The NSS proteins in mammals are responsible for clearing the synapse after a nerve signal, transporting neurotransmitters back into the axon and making it ready for another signal. The NSS proteins are common targets for anti-depressants.

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Publications

Puig E, Tolchard J, Riera A, Carulla N.
ACS chemical neuroscience (2020)

Drysdale R, Cook CE, Petryszak R, Baillie-Gerritsen V, Barlow M, Gasteiger E, Gruhl F, Haas J, Lanfear J, Lopez R, Redaschi N, Stockinger H, Teixeira D, Venkatesan A, Elixir Core Data Resource Forum , Blomberg N, Durinx C, McEntyre J.
Bioinformatics (Oxford, England) Volume 36 (2020) p.2636-2642

Kosol S, Contreras-Martos S, Piai A, Varadi M, Lazar T, Bekesi A, Lebrun P, Felli IC, Pierattelli R, Tompa P.
Scientific reports Volume 10 (2020) p.5753

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