EMD-49261

Single-particle
3.4 Å
EMD-49261
3D View Gallery
Deposition: 16/02/2025
Map released: 18/02/2026
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49261

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9nco summary report (pdf.gz) Map-9nco FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

IN-ML-15 bound to IGF1Rzip

EMD-49261

Single-particle
3.4 Å
EMD-49261
3D View Gallery
Deposition: 16/02/2025
Map released: 18/02/2026
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: IN-ML-15 IGF1Rzip complex
Fitted models: 9nco

Deposition Authors: Kirk NS
An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.
Selicharova I , Kirk NS , Kertisova A , Lubos M , Mitrova K, Tichackova T , Zakova L , Chrudinova M, Brezinova J , Harant K, Voldrich J , Hajek M , Huffman DM, Jiracek J
(2026) Sci Adv , 12 , eaeb7558 - eaeb7558
PUBMED: 42139356
DOI: doi:10.1126/sciadv.aeb7558
ISSN: 2375-2548
Grant Support: