XEN1101 bound KCNQ2/3 heteromer co-expressed with CaM, 3:1 stoichiometry, state 2

XEN1101 bound KCNQ2/3 heteromer co-expressed with CaM, 3:1 stoichiometry, state 1

XEN1101 bound KCNQ2/3 heteromer co-expressed with CaM, 3:1 stoichiometry, state 3

XEN1101 bound KCNQ2/3 heteromer co-expressed with CaM, 3:1 stoichiometry, state 4

VPS34-CII (VPS34 199-REIE-202 > 199-AAAA-202 mutant) bound to RAB5A-GTP (Q79L); unsharpened composite map

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L), focused refinement on the base of the complex

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, focused refinement on the adaptor arm

VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG) bound to RAB5A (Q79L) on the VPS34 and VPS15 subunits, primary map processed with CryoTEN

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L, focused refinement on the interface between RAB5A and VPS34)

Cryo-EM structure of the PseTnsAB paired-end complex (right end) in the presence of Mn

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L), primary composite map processed with CryoTEN

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L, focused refinement on the adaptor arm)

Apo VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG), consensus refinement map processed with CryoTEN

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L, focused refinement on the kinase arm)

VPS34-CII (VPS34 199-REIE-202 > 199-AAAA-202 mutant) bound to RAB5A-GTP (Q79L), consensus refinement

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, focused refinement of the RAB5A interface with VPS15

Human complex II-BATS bound to membrane-attached Rab5a-GTP

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, focused refinement on the kinase arm

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit; unsharpened composite map

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, composite map processed with CryoTEN.

VPS34-CII bound to RAB5A-GTP 1-212 (C19S, C63S, Q79L) on the VPS34 subunit, primary map processed with CryoTEN

VPS34-CII bound to RAB5A-GTP 1-212 (C19S, C63S, Q79L) on the VPS15 subunit, primary map processed with CryoTEN

Cryo-EM structure of the PseTnsAB paired-end complex (right end) in the presence of Mg

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, consensus refinement

Cryo-EM structure of the PseTnsAB paired-end complex (left end) in the presence of Mg

Cryo-EM Structure of the N600A Quinol-Dependent Nitric Oxide Reductase

ALECT2 type Ia filament from renal biopsy tissue of an individual with ALECT2 amyloidosis

ALECT2 type IIa filament from renal biopsy tissue of an individual with ALECT2 amyloidosis

ALECT2 type Ib filament from renal biopsy tissue of an individual with ALECT2 amyloidosis

ALECT2 type IIb filament from renal biopsy tissue of an individual with ALECT2 amyloidosis

ALECT2 type III filament from renal biopsy tissue of an individual with ALECT2 amyloidosis

Human Trpm4 at 8 degrees Celsius

In situ subtomogram average of the M. maripaludis 70S ribosome

Human trpm4 in complex with PBA at 8 degrees Celsius

CryoEM structure of human NSUN2 with tRNA Lys(CTT) (Conformation 2)

SARM1 TIR with BEXi adduct 6

Human Trpm4 with calcium at 37 degrees celsius

In situ subtomogram average of the M. maripaludis Hdr-Vhu-Fwd supercomplex

SARM1 TIR with BEXi adduct 17

Human Trpm4 with calcium and PBA at 37 degrees celsius

Map of the 50S ribosomal subunit with E-tRNA and RsfS from the alphaproteobacteria Asaia platycodi

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to tRNA Lys(CTT) (D-arm conformation)

CryoEM structure of human NSUN2 with tRNA Lys(CTT) (Conformation 1)

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to tRNA Lys(TTT) (No D-arm conformation)

CryoEM structure of human NSUN2 with tRNA Lys(CTT) and SFG (D-arm conformation)

CryoEM structure of human NSUN2 with tRNA Lys(CTT) and SFG (No D-arm conformation)

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to tRNA Lys(TTT) (D-arm conformation)

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to tRNA Lys(CTT) (No D-arm conformation)

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to a pre-tRNA Leu(CAA) intron

Zebrafish Abcb4 in IF-Medium conformation (IF-Medium)

Zebrafish Abcb4 in IF-Narrow conformation in the presence of Elacridar (ELA-IF-Narrow)

Zebrafish Abcb4 in IF-narrow conformation in the presence of Tariquidar (TQR-IF-Narrow)

Zebrafish Abcb4 in IF-Wide conformation in the presence of Tariquidar (TQR-IF-Wide)

Zebrafish Abcb4 in IF-Wide conformation (IF-Wide)

Zebrafish Abcb4 in IF-medium conformation in the presence of Tariquidar (TQR-IF-Medium)

Zebrafish Abcb4 in IF-Medium conformation in the presence of Elacridar (ELA-IF-Medium)

Zebrafish Abcb4 in IF-Wide conformation in the presence of Elacridar (ELA-IF-Wide)

Zebrafish Abcb4 in IF-narrow conformation (IF-Narrow)

Zebrafish Abcb4 in IF-narrow conformation in the presence of Vincristine (VCR-IF-Narrow)

Cryo-EM structure of PPAT-NUDT5 complex bound to 6-benzylthioinosine-5'-monophosphate (6-benzylTIMP)

Cryo-EM structure of PPAT-NUDT5 complex bound to 6-methylthioinosine-5'-monophosphate (6-meTIMP)

Zebrafish Abcb4 in IF-Wide conformation in the presence of Vincristine (VCR-IF-Wide)

Cryo-EM structure of PPAT-NUDT5 complex bound to adenosine-5'-monophosphate (AMP)

Zebrafish Abcb4 in IF-medium conformation in the presence of Vincristine (VCR-IF-Medium)

State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac

State 3 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac

State 2 focused on PHD FYR of MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac

MLL4FC bound to a nucleosome with p53 RE

State 2 focused on H3 N terminal tail of MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac

Hna Monomer

A ternary complex of NUT with BAK1 and SCREW2

Structure of DOCK6-Rac1 complex

In situ subtomogram average of a ribosome bound to ribosome associated vesicle in primary neurons expressing KDEL tagged with mNeonGreen (mNeon-KDEL)

Structure of DOCK6-Cdc42 complex protomer

Structure of DOCK6 tetramer complexed with Rac1

Structure of DOCK6-Rac1 complex protomer

A Wnt3a/Fzd8-CRD/LRP6-E3E4-LA complex with FKBP

Structure of DOCK6 tetramer

Wnt3a signalosome extracellular complex

Structure of DOCK6 octamer

A Wnt3a/Fzd8-CRD/LRP6-E3E4 complex with FKBP

Structure of DOCK6-Cdc42 complex

RPS26dC HEK mutant 80S ribosome bound to Kozak mRNA (RPS26dC-Kozak)

WT-HEK 80S ribosome bound to TISU mRNA (WT-TISU)

electron tomograms of epon embedded P. falciparum stage V gametocytes (NF54)

electron tomograms of epon embedded P. falciparum stage V gametocytes with PfMIC60 knockout

electron tomograms of epon embedded P. falciparum stage V gametocytes with PfMIC19/PfMIC60 double knockout

RPS26dC HEK mutant 80S ribosome bound to TISU mRNA (RPS26dC-TISU)

electron tomograms of epon embedded P. falciparum stage V gametocytes with PfMIC19 knockout

Neuraminidase NA isolated from the H1N1 strain A/Victoria/2570/2019 propagated in eggs

Cryo-EM structure of P. urativorans 70S ribosome after 72h acute stress - State 3: E-tRNA/P-tRNA/Balon

Cryo-EM structure of P. urativorans 70S ribosome after 72h acute stress - State 4: E-tRNA/RaiA/Balon

Structure of Geobacillus stearothermophilus RNase P ribozyme in complex with precursor tRNA in 10 mM Ca2+

Cryo-EM map of vaccine elicited antibody 22F5 bound to post-fusion conformation of Langya virus F protein

Cryo-EM structure of antibody 22F5 in complex with pre-fusion stabilized LayV-F

Human AGO2 bound to a miR-20a guide and a position 10-11 mismatched target

Structure of AGO2 vise-RISC

Structure of AGO2 wedging RISC (wedg-RISC)

Structure of AGO2 mature RISC (mat-RISC)

Structure of AGO2 primary RISC (pri-RISC)

Structure of AGO2 passenger-ejecting RISC (ej-RISC)

Cryo-EM structures of the human ABCB7 in the apo state

Cryo-EM structure of the human ABCB7 in occluded state

TamA complex with TamB DUF490 in lipid nanodisc

TamA complex with TamB DUF490 in detergent micelles.

A complex of PTH1R/Gs bound to a PTHrP analogue with three beta-amino acids

A complex of PTH1R/Gs bound to a PTHrP analogue with five beta-amino acids

Cryo-EM structure of human ABCB7 in complex with CoPP:GSH/ADPVO4

apo state of Mengla Virus Glycoprotein

glycoprotein of mengla virus with MR191 Fab bound

MprF from Pseudomonas aeruginosa mutant, H566C in nanodisc, C2 symmetry

MprF from Pseudomonas aeruginosa mutant- H386C/F389C in nanodisc, C2 symmetry

H4-4KAc chromatosome Class 1

Cryo-EM structure of ATP-bound Arabidopsis thaliana fatty acid transporter CTS

Cryo-EM structure of Arabidopsis thaliana fatty acid transporter CTS

Cryo-EM structure of IBA-CoA-bound Arabidopsis thaliana fatty acid transporter CTS

Cryo-EM structure of C12:0-CoA-bound Arabidopsis thaliana fatty acid transporter CTS

H4-4KAc chromatosome Class 2

Cryo-EM structure of 2,4-DB-CoA-bound Arabidopsis thaliana fatty acid transporter CTS

The cryo-EM structure of FD4_orientation2 bound Lewy fold fibril.

Narrow leaf 1 (NAL1) mutant carrying R233H from India

The cryo-EM structure of FD4 bound Lewy fold fibril.

Structure of SARS-CoV-2 Spike in complex with antibodies S309 and CT1-1

Cryo-EM structure of human VAChT in complex with VSM

Cryo-EM structure of human VAChT at protonated state

Cryo-EM structure of the family 2A encapsulin from Mycolicibacterium smegmatis

the open state of NAL1 from indica with R233H

Structure of SARS-CoV-2 Spike in complex with antibodies S309 and CT1-5.

Cryo-EM structure of reduced form of formatedehydrogenase from Rhodobacter aestuarii (RaFDH) with NADH

Local refinement region of SARS-CoV-2 spike RBD in complex with antibodies CT1-5.

Local refinement region of SARS-CoV-2 spike RBD in complex with antibodies S309 and CT1-1.

Consensus cryo-EM map for the structure of human PI3KC3-C1 complex

Cryo-EM structure of human NCC with indapamide

Cryo-EM structure of human NCC with chlorthalidone (C2)

Cryo-EM structure of NCLX without calcium (class 2)

Cryo-EM structure of human NCC with chlorthalidone

Designed one-component T=3 quasisymmetric protein nanocage pentamer sub-particle region

Defense-associated reverse transcriptase 1 (DRT1) filament

Subtomogram average structure of flagellar export apparatus and MS-ring of deleted flhA in Borrelia burgdorferi

CryoEM structure of the soluble-WRAPed membranous portion of MspA (Mycobacterium smegmatis porin), dimerized along the native interface.

Subtomogram average structure of MS-ring in Borrelia burgdorferi

Designed one-component T=3 quasisymmetric protein nanocage

Designed one-component T=13 quasisymmetric protein nanocage hexamer sub-particle region

Designed one-component T=13 quasisymmetric protein nanocage pentamer sub-particle region

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free NC state 1

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free C state

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GDP-bound, AHD-closed C state 2, plunge-frozen 15 seconds after GDP addition

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GDP-bound, AHD-closed C state 2, plunge-frozen 8 seconds after GDP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Go complex in nucleotide-free NC state 2

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GDP-bound, AHD-closed C state 1, plunge-frozen 15 seconds after GDP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 complex in nucleotide-free C state 2

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GDP-bound, AHD-closed C state 1, plunge-frozen 8 seconds after GDP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 (delipidated) complex in nucleotide-free C state

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open C state 2, plunge-frozen 0-5 seconds after GTP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 complex in nucleotide-free NC state 3

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 complex in nucleotide-free C state 1

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-closed C state 2, plunge-frozen 8 seconds after GTP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 complex in nucleotide-free NC state 2

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 complex in nucleotide-free NC state 1

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gq (delipidated) complex in nucleotide-free C state

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-closed C state 1, plunge-frozen 8 seconds after GTP addition

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open C state 1, plunge-frozen 0-5 seconds after GTP addition

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open C state, plunge-frozen 8 seconds after GTP addition

Cryo-EM structure of human Neurotensin Receptor 1 (hNTSR1)-Gi1 (delipidated) complex in nucleotide-free NC state

APS kinase from Entamoeba histolytica

cryo-EM structure of RIBEYE SAM thin filament

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open NC state 4, plunge-frozen 0-5 seconds after GTP addition

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open NC state 2, plunge-frozen 0-5 seconds after GTP addition

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open NC state 3, plunge-frozen 0-5 seconds after GTP addition

cryo-EM structure of RIBEYE SAM thick filament

cryo-EM structure of RIBEYE B' filament

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open NC state 1, plunge-frozen 0-5 seconds after GTP addition

Human KCNQ3-XEN1101 complex in the presence of PIP2

Psl polysaccharide related protein structures

Human KCNQ3-CaM in apo state

Cryo-EM structure of H4S47GlcNAc nucleosome at 3.39 angstrom

Psl polysaccharide related protein structures

Structure of Klebsiella pneumoniae trypsin-HamAB bound with DNA, trimer

Structure of Klebsiella pneumoniae trypsin-HamAB bound with DNA, dimer

Structure of Klebsiella pneumoniae trypsin-HamAB bound with DNA, monomer

Subtomogram average of D. discoideum ribosome (from EMPIAR-11899) using particles selected at least 43 nm away from lamella surface

Subtomogram average of the D. discoideum vault complex using D39 symmetry (from EMPIAR-11845)

Subtomogram average of gamma tubulin ring complex capping microtubule minus ends from purified S. uvarum spindle pole bodies

Subtomogram average of D. discoideum ribosome (from EMPIAR-11899) using particles selected within 43 nm of lamella surface

Subtomogram average of H. sapiens ribosome (from EMPIAR-11538)

In situ subtomogram average of filamentous IMPDH in mycophenolic acid-treated HeLa cells

Subtomogram average of H. sapiens 13-protofilament microtubule

Subtomogram average of D. discoideum nuclear pore complex (from EMPIAR-11943)

Subtomogram average of H. sapiens T-complex protein Ring Complex (TRiC) (from EMPIAR-11538)

Subtomogram average of C. reinhardtii ribosome (from EMPIAR-11830)

Subtomogram average of human Hsp60-Hsp10 (from EMPIAR-13145)

Structure of a stalled E. coli 70S RNC-NuoK-86 in complex with the membrane protein insertase SecYEG-YidC

Structure of a stalled E. coli 70S RNC-NuoK-86 in complex with the membrane protein insertase SecYEG-YidC (Focused Refinement)

Structure of a stalled E. coli 70S RNC-NuoK-86 in complex with the membrane protein insertase SecYEG-YidC (Composite map)

Subtomogram average of S. cerevisiae ribosome

Subtomogram average of V. fischeri ribosome

Structure of human TRPV1 in Complex with JNJ-17203212

Structure of human TRPV1 in Apo state

Structure of human TRPV1 in complex with Asivatrep

Structure of human TRPV1 in complex with Mavatrep

cryoEM structure of S1P3 in complex with heterotrimeric G protein

Cryo-EM structure of S1P2 in complex with heterotrimeric G protein

Structure of human TRPV1 in complex with 6-Iodo-CAP (CAY10448)

Cryo-EM structure of SHIV-elicited CN81-2029 Fab in complex with HIV Env trimer Q23-SCT27

Cryo-EM structure of the human KCNQ2/3 heteromer channel

Atg2-Atg18 complex from yeast

Cryo-EM structure of SHIV-elicited CI93-1365 Fab in complex with HIV Env trimer Q23-SCT27

Cryo-EM structure of SHIV-elicited CE79-1571 Fab in complex with HIV Env trimer Q23-SCT27

Cryo-EM structure of Protein involved in colonization (Pic) from Enteroaggregative Escherichia coli complexed with the fragment antigen binding domain of monoclonal antibody 40

Cryo-EM structure of human NXPE1

Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody G12

Pneumococcal choline binding CbpE surface protein bounds to 5992-2 Fab

Cryo-EM structure of Secreted extracellular protein A (SepA) from Shigella flexneri complexed with the fragment antigen binding domain of monoclonal antibody 40

Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 40

Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 15

Pneumococcal choline binding CbpE surface protein bounds to multiple 5992-2 Fabs

Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 25

Cryo-EM Structure of Turbo sazae ferritin chain A

Cryo-EM structure of nucleotide-free Streptococcus thermophilus FoeAB 2

Cryo-EM structure of Streptococcus thermophilus FoeAB in complex with AMPPNP

KCNQ2 homotetramer in apo state

ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2

Cryo-EM structure of Streptococcus thermophilus FoeAB E504Q mutant in complex with ATP

Cryo-EM structure of nucleotide-free Streptococcus thermophilus FoeAB 1

Cryo-EM Structure of Turbo sazae ferritin chain B

Cryo-EM structure of human LAS1L-NOL9 complex

Cryo-EM structure of Streptococcus thermophilus FoeAB in complex with ADP

ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3

XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 4

XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 2

ICA-1103811 bound KCNQ2/3 heteromer with 2:2 stoichiometry

ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1

Cryo-EM structure of Streptococcus thermophilus FoeAB in complex with AMPPNP in peptidisc

XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3

Cryo-EM structure of nucleotide-free Streptococcus thermophilus FoeAB 3

Cryo-EM structure of Streptococcus thermophilus FoeAB in complex with ATP and ADP

XEN1101 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 1

IscB-TID truncated and wRNA bound to Target ssRNA

Engineered IscB and wRNA bound to Target ssDNA

Engineered IscB and wRNA bound to Target ssDNA

IscB-TID truncated and wRNA bound to Target ssRNA

XEN1101 bound KCNQ2/3 heteromer with 2:2 stoichiometry

KCNQ2/3 heterotetramer with 2:2 stoichiometry

KCNQ2/3 heterotetramer with 3:1 stoichiometry

SARS-CoV-2 polymerase with incorporated and pre-incorporated AT-9052-Sp

XEN1101 bound KCNQ2/3 heteromer co-expressed with CaM, 2:2 stoichiometry