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Cryo-EM structure of TRP melastatin channel in the putative desensitized state, with EGTA
CRYO-EM FOCUSED REFINEMENT MAP OF HUMAN 80S RIBOSOME WITH A/P/E-SITE TRNA AND MRNA CONTAINING N1-METHYLPSEUDOURIDINE
CRYO-EM CONSENSUS MAP OF HUMAN 80S RIBOSOME WITH A/P/E-SITE TRNA AND MRNA CONTAINING N1-METHYLPSEUDOURIDINE
Structure of proteinase K from energy-filtered MicroED data using a 20 eV slit width
Structure of proteinase K from energy-filtered MicroED data using a 10 eV slit width
Structure of proteinase K from energy-filtered MicroED data using a 5 eV slit width
ATTRv-V30M type III filament from gastrocnemius muscle biopsy of an individual with a V30M mutation.
ATTRv-V30M type I filament from gastrocnemius muscle biopsy of an individual with a V30M mutation.
ATTRv-V30M type II filament from gastrocnemius muscle biopsy of an individual with a V30M mutation.
ATTRv-F64S type I filament from vitreous body of an individual with a F64S mutation.
ATTRv-F64S type III filament from vitreous body of an individual with a F64S mutation.
ATTRv-K35N filament from gastrocnemius muscle biopsy of an individual with a K35N mutation.
ATTRv-F64S type II filament from vitreous body of an individual with a F64S mutation.
ATTRv-T59K filament from gastrocnemius muscle biopsy of an individual with a T59K mutation.
ATTRv-A97S type II filament from gastrocnemius muscle biopsy of an individual with a A97S mutation.
ATTRv-A97S type I filament from gastrocnemius muscle biopsy of an individual with a A97S mutation.
ATTRv-V30A type I filament from gastrocnemius muscle biopsy of an individual with a V30A mutation.
ATTRv-E61K filament from gastrocnemius muscle biopsy of an individual with a E61K mutation.
ATTRv-F64S type IV filament from vitreous body of an individual with a F64S mutation.
ATTRv-F33V filament from gastrocnemius muscle biopsy of an individual with a F33V mutation.
ATTRv-G83R type II filament from gastrocnemius muscle biopsy of an individual with a G83R mutation.
ATTRv-G83R type I filament from gastrocnemius muscle biopsy of an individual with a G83R mutation.
ATTRv-V30A type II filament from gastrocnemius muscle biopsy of an individual with a V30A mutation.
ATTRv-G83R type II filament from gastrocnemius muscle biopsy of an individual with a G83R mutation.
ATTRv-A97S type III filament from gastrocnemius muscle biopsy of an individual with a A97S mutation.
Cryo-EM structure of human CNNM4(E284A) tetramer with Magnesium and MgATP in outward-facing state
Cryo-EM structure of IGFBP7 dodecamer. The 3D refinement was focused on the central part of the dodecamer, which contains 12 IgC2 domains.
Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state
Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptor (IP3R2) in the presence of IP3/Ca2+/ATP
CryoEM structure of Brucella melitensis CobN-CobS-CobT holoenzyme with AMPPNP (conformation 2)
CryoEM structure of Brucella melitensis CobN-CobS-CobT holoenzyme with AMPPNP (conformation 1)
CryoEM structure of Brucella melitensis CobS-CobT complex with AMPPNP (conformation 1)
CryoEM structure of Brucella melitensis CobS dodecamer 2 without AMPPNP
CryoEM structure of Brucella melitensis CobS-CobT complex with AMPPNP (conformation 2)
CryoEM structure of Brucella melitensis CobS(E142Q)-CobT complex with ATP (conformation 1)
CryoEM structure of Brucella melitensis CobS dodecamer 2 without ATP
CryoEM structure of Brucella melitensis CobS-CobT complex with AMPPNP (conformation 3)
CryoEM structure of Brucella melitensis CobS(E142Q)-CobT complex with ATP (conformation 2)
CryoEM structure of Brucella melitensis CobS dodecamer 1 without AMPPNP
CryoEM structure of Brucella melitensis CobS-CobT complex with AMPPNP (conformation 5)
CryoEM structure of Brucella melitensis CobN-CobS-CobT holoenzyme with AMPPNP (conformation 3)
CryoEM structure of Brucella melitensis CobS(E142Q)-CobT complex with ATP (conformation 3)
CryoEM structure of Brucella melitensis CobS hexamer without AMPPNP
CryoEM structure of Brucella melitensis CobS-CobT complex with AMPPNP (conformation 4)
focused structure of regulatory domains of cis-basal conformer of human CBS induced by non-activating allosteric SAO ligand - by Helical approach
Structure of trans-basal conformer of wild-type human CBS alone (internal aldemine)- by single particle approach
Structure of cis-basal conformer of human CBS induced by non-activating allosteric SAO ligand - by single particle approach.
Structure of trans-basal conformer of wild-type human CBS enzyme in absence of substrate and allosteric activators- by Helical approach
CryoEM structure of the E494A Quinol-Dependent Nitric Oxide Reductase
Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptor (IP3R2)in the presence of IP3/Ca2+/ATP (Composite map)
Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state (composite map)
Cryo-EM structure of L9-21 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)
Structure of the sodium-dependent phosphate importer SLC34A2 S135C, apo
Cryo-EM structure of L9-11 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)
Structure of the sodium-dependent phosphate importer SLC34A2, Pi- and Na+-bound
Structure of the sodium-dependent phosphate importer SLC34A2 S135C, Pi- and Na+-bound
Structure of the sodium-dependent phosphate importer SLC34A2, Na+-bound
Structure of the sodium-dependent phosphate importer SLC34A2, PFA- and Na+-bound
Cryo-EM structure of Posidonia oceanica L-PSI-LHCI-LHCII supercomplex
Cryo-EM structure of Posidonia oceanica L-PSI-LHCI-LHCII supercomplex - PSI core focused map
Cryo-EM structure of Posidonia oceanica PSI-LHCI supercomplex - Consensus map
Cryo-EM structure of Posidonia oceanica PSI-LHCI supercomplex - PSI core focused map
Cryo-EM structure of Posidonia oceanica PSI-LHCI supercomplex - LHCI belt focused map
Structure of trans-basal conformer of human CBS trapped in PLP-serine external aldemine intermediate (CBS-PLP-Ser)- by Helical approach
Cryo-EM structure of Posidonia oceanica L-PSI-LHCI-LHCII supercomplex - LHCI belt focused map
Cryo-EM structure of Posidonia oceanica L-PSI-LHCI-LHCII supercomplex
Cryo-EM structure of Posidonia oceanica PSI-LHCI supercomplex - Composite map
Structure of trans-basal conformer of human CBS trapped in PLP-serine external aldemine intermediate (CBS-PLP-Ser)- by single particle approach
Structure of trans-basal conformer of human CBS trapped in PLP-aminoacrylate intermediate state (CBS PLP-AA)- by Helical processing.
Structure of trans-basal conformer of human CBS trapped in PLP-aminoacrylate intermediate state (CBS PLP-AA)- by single particle approach
Cryo-EM structure of Posidonia oceanica L-PSI-LHCI-LHCII supercomplex - Lhca1-Lhca4 + LHCII focused map
Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb11, local refinement
Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb4, local refinement
Cryo-EM map of fibroblast activation protein (FAP) and ligand complex
Structure of VcINDY-alpha ketoglutarate complex in Ci-Ci conformation
Cryo-EM structure of wild-type human CNNM4 tetramer with Magnesium and MgATP in outward-facing state
Cryo-EM structure of human CNNM4(D262C) tetramer with Magnesium and MgATP in occluded state
Cryo-EM structure of human CNNM4(K113A/R140A/R141A) tetramer with Magnesium and MgATP in outward-facing state
Cryo-EM structure of dCas9 bound to DNA duplex with mixed extension lengths (2-14 bp)
Cryo-EM structure of dCas9 bound to DNA duplex, HNH domain resolved
Cryo-EM structure of dCas9 bound to DNA duplex with mixed extension lengths (2/8/14 bp)
Cryo-EM structure of dCas9 bound to DNA duplex, Rec3 domain resolved
Cryo-EM structure of dCas9 bound to DNA duplex with 12 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 14 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 13 bp extension
CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-R196-L226
CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-L3-S209A
CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-L3-N207A
CryoEM structure of EV-D68 strain Fermon in complex with MFSD6-R196-L226-NAtreat
Subtomogram averaged A/T, P state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A/T, P, Z state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged P, E state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A, P, Z state of the 80S ribosome in rat hippocampal neuron
in situ idle-1 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A/T, P, E state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A/P, P/E, eEF2 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged Disome 1 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged P state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged eEF2, eIF5A, SERBP1 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A, P state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged Disome 1 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A, P, E state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged Disome 2 state of the 80S ribosome in rat hippocampal neuron
in situ idle-2 state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged eEF2, E state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A/A, P/E state of the 80S ribosome in rat hippocampal neuron
Subtomogram averaged A/P, P/E state of the 80S ribosome in rat hippocampal neuron
Focused map of the CSol activation core part, Apo-state RyR1 with ACP in the native membrane
70S map (consensus map) for:"70S ribosome of marine cold bacterium Pseudoalteromonas translucida (P. haloplanktis) TAC125.
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map10)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map8)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map11)
Structure of the human debranched intron spliceosome (DIS) (Map10)
Focused map of the BSol cytosolic shell part, Apo-state RyR1 with ACP in the native membrane
50S-focused map for:"70S ribosome of marine cold bacterium Pseudoalteromonas translucida (P. haloplanktis)TAC125.
30S-focused map for:"70S ribosome of marine cold bacterium Pseudoalteromonas translucida (P. haloplanktis)TAC125.
Single particle reconstruction of Rhodospirillum rubrum encapsulin:encapsulated ferritin complex
Focused refinement of closed encapsulin pentamer from symmetry expansion of icosahedral single particle reconstruction of the Rhodospirillum rubrum encapsulin:encapsulated ferritin complex
Focused refinement of Rhodospirillum rubrum encapsulated ferritin within the encapsulin nanocompartment
Focused map of the N-Terminal cytosolic shell part, Apo-state RyR1 in the native membrane solved by "SPA"
Focused map of the BSol cytosolic shell part, Apo-state RyR1 in the native membrane solved by "SPA"
Focused refinement of open encapsulin pentamer from symmetry expansion of icosahedral single particle reconstruction of the Rhodospirillum rubrum encapsulin:encapsulated ferritin complex
Focused map of the CSol activation core part, Apo-state RyR1 in the native membrane solved by "SPA"
Focused map of the TMD/TaF/CTD part, Apo-state RyR1 in the native membrane solved by "SPA"
Consensus map, Apo-state RyR1 in the native membrane solved by "SPA"
Focused map of the TMD/TaF/CTD part, Apo-state RyR1 with ACP in the native membrane
Focused map of the N-Terminal cytosolic shell part, Apo-state RyR1 with ACP in the native membrane
Structure of the human debranched intron spliceosome (DIS) (Map1)
Structure of the human debranched intron spliceosome (DIS) (Map2)
Structure of the human debranched intron spliceosome (DIS) (Map4)
Structure of the human debranched intron spliceosome (DIS) (Map7)
Structure of the human debranched intron spliceosome (DIS) (Map3)
Structure of the human debranched intron spliceosome (DIS) (Map6)
Structure of the human debranched intron spliceosome (DIS) (Map5)
Structure of the human debranched intron spliceosome (DIS) (Map8)
Structure of the human debranched intron spliceosome (DIS) (Map9)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map1)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map3)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map2)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map4)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map5)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map7)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map9)
Structure of the human intron-lariat spliceosome-Aquarius (ILSaqr) (Map6)
Cryo-EM structure of the CO dehydrogenase (CODH) subcomplex from Methanosarcina acetivorans
Cryo-EM map of the acetyl-CoA decarbonylase/synthase (ACDS) complex from Methanosarcina acetivorans
Cryo-EM structure of the monomeric WDR11-FAM91A1-C17orf75 complex
Cryo-EM structure of the dimeric WDR11-FAM91A1-C17orf75 complex (focused on body1)
Cryo-EM structure of the dimeric WDR11-FAM91A1-C17orf75 complex (focused on body2)
Cryo-EM structure of the dimeric WDR11-FAM91A1-C17orf75 complex (focused on body2-FC)
Cryo-EM structure of the dimeric WDR11-FAM91A1-C17orf75 complex (consensus map)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened AHD2 local refinement map from cryoSPARC)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened CORE2 local refinement map from cryoSPARC)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened T2a local refinement map from cryoSPARC)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened AHD1 local refinement map from cryoSPARC)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened CORE1 local refinement map from cryoSPARC)
V-shaped (channel-formed), ATP-bound, VX809-bound, T2a-nanobody-bound conformation of wild-type human CFTR (sharpened WalkerB2 local refinement map from cryoSPARC)
Cryo-EM structure of dCas9 bound to DNA duplex with 10 bp extension
Cryo-EM structure of the Arabidopsis salicylic acid-bound NPR1-MED15 complex
Cryo-EM structure of dCas9 bound to DNA duplex with 11 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 9 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 8 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 7 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 6 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 4 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 5 bp extension
Cryo-EM structure of dCas9 bound to DNA duplex with 3 bp extension
Cryo-EM structure of SARS-CoV-2 Omicron neutralizing antibody L52 with BA.5 RBD and SP1-77 Fab complex
Cryo-EM structure of SARS-CoV-2 Omicron neutralizing antibody AB2-122 with BA.5 RBD and SP1-77 Fab complex
Cryo-EM structure of SARS-CoV-2 Omicron neutralizing antibody S212 with BA.5 RBD and SP1-77 Fab complex
Cryo-EM structure of dCas9 bound to DNA duplex with 2 bp extension
Cryo-EM structure of an inactive dimer of the C. elegans EGFR (LET-23) extracellular region bound to LIN-3.
Vibrio cholerae Glycine Riboswitch - glycine bound at 2.9A resolution
Cryo-EM structure of an active dimer of the C. elegans EGFR (LET-23) extracellular region bound to LIN-3
Cryo-EM structure of an active dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion bound to LIN-3.
Cryo-EM structure of a weak dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion
Cryo-EM structure of a preformed dimer of the C. elegans EGFR (LET-23) extracellular region
Cryo-electron tomogram of vesicular stomatitis virus (VSV) with rabies virus glycoprotein
Structure of AT118-R nanobody in complex with the angiotensin II type I receptor bound to L-162,313
Structure of AT118-R nanobody in complex with the angiotensin II type I receptor bound to losartan
Cryo-electron tomogram of vesicular stomatitis virus (VSV) with rabies virus glycoprotein
Cryo-EM structure of the chromatin remodeler Rad26 bound to the nucleosome at SHL6
Cryo-EM map of Plasmodium falciparum 20S proteasome bound to an asparagine-ethylenediamine based inhibitor TDI6245
Polyrod without P-ring formed by FlgG (G65V) from the Salmonella TH26292 strain
E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-open conformation (a).
E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-closed conformation.
E. coli RNA polymerase elongation complex containing the unnatural dP:Z*TP base pair in a trigger-loop-open conformation (b).
Cryo-EM structure of the closed-closed dextran utilisome (BT3087-BT3090), with GHdex D297A E360A catalytic inactivation, with bound IMO4, IMO6 and IMO8
Cryo-EM structure of the open-closed dextran utilisome (BT3087-BT3090), with GHdex D297A E360A catalytic inactivation, with bound IMO4, IMO6, IMO7, and IMO8
Focussed map of ternary PROTAC-mediated complex consisting of Cereblon, DDB1 and BRD4-BD1, non-covalently linked by JQ1-AcN
Consensus map of ternary PROTAC-mediated complex consisting of Cereblon, DDB1 and BRD4-BD1, non-covalently linked by JQ1-AcN
Cryo-EM structure of TRP melastatin channel in the desensitized state, with icilin (10min)
Cryo-EM structure of TRP melastatin channel in the putative intermediate 3, without CHS
Cryo-EM structure of TRP melastatin channel in the putative twofold intermediate 1 state, with EGTA
Cryo-EM structure of TRP melastatin channel in the putative desensitized state, without CHS
Cryo-EM structure of TRP melastatin channel in the putative intermediate 2 state, with EGTA