EMD-75305

Single-particle
3.95 Å
EMD-75305
3D View Gallery
Deposition: 28/01/2026
Map released: 02/09/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75305

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-10nk summary report (pdf.gz) Map-10nk FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Xenopus KCNQ1 Intermediate State (E1R/R2E) in complex with UCL2077

EMD-75305

Single-particle
3.95 Å
EMD-75305
3D View Gallery
Deposition: 28/01/2026
Map released: 02/09/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Xenopus laevis, Homo sapiens
Sample: Potassium voltage-gated channel subfamily KQT member 1 (E150R/R221E) in complex with calmodulin and UCL2077
Fitted models: 10nk

Deposition Authors: Kyriakis E , Eldstrom J , Van Petegem F , Fedida D , Van Petegem F , Fedida D
Structural and kinetic mechanisms of state-dependent potassium channel inhibition.
Kyriakis E , Roscioni A , Eldstrom J , Sastre D , Dou Y, Taddei A , Molinarolo S, Tian M , Maragliano L , Van Petegem F , Fedida D
(2026) Sci Adv , 12 , eaef8456 - eaef8456
PUBMED: 42826183
DOI: doi:10.1126/sciadv.aef8456
ISSN: 2375-2548