EMD-52874

Single-particle
3.06 Å
EMD-52874
3D View Gallery
Deposition: 21/02/2025
Map released: 02/09/2026
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52874

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ihn summary report (pdf.gz) Map-9ihn FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of NLRP3 bound to the inhibitor BAL-1516 at 3.06 Ang resolution

EMD-52874

Single-particle
3.06 Å
EMD-52874
3D View Gallery
Deposition: 21/02/2025
Map released: 02/09/2026
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of human NLRP3 bound to the inhibitor BAL-1516
Fitted models: 9ihn

Deposition Authors: Torp J, Wilhelmsen K, Hartman G, Hagelueken G, Geyer M

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold
Torp J, Geyer M
To Be Published