Structural basis of autoantibody binding in IgLON5 disease

Structural basis of autoantibody binding in IgLON5 disease

CryoEM structure of the vacant Candida auris 80S ribosome

Cryo-EM structure of ClassIII Lanthipeptide modification enzyme TherKC with chain A bounded to substrate TherA and ATPrS.

Cryo-EM structure of recombinant mutant tau filaments

Cryo-EM structure of ClassIII Lanthipeptide modification enzyme TherKC with chain A bounded to substrate TherA and ATPrS.

DPR epimerase complex, PMD-bound state

Structure of neutralizing antibody B9 with MPXV M1R

Cryo-EM structure of the insect sex pheromone receptor ApisOR22-Orco heterocomplex

DPR epimerase complex, DLM-bound state

Cryo-EM structure of the insect sex pheromone receptor ApisOR22-Orco heterocomplex bound with nepetalactone in the open state

DPR epimerase complex, substrate-bound state

Local structure of MERS-CoV S protein bound with receptor DPP4 in the conformation 2 (2 up RBD and 2 DPP4 bound)

Cryo-EM structure of MERS-CoV S protein bound with receptor DPP4 in the conformation 1 (1 up RBD and 1 DPP4 bound).

Local structure of MERS-CoV RBD protein bound with receptor DPP4 in the conformation 2 (2 up RBD and 2 DPP4 bound)

Cryo-EM structure of MERS-CoV S protein bound with receptor DPP4 in the conformation 3 (3 up RBD and 3 DPP4 bound).

DPR epimerase complex, quabodepistat-bound state

Structure of MERS-CoV S protein with 3down-RBDs

Post-fusion structure of MERS-CoV spike glycoprotein

Structure of neutralizing antibody G4 with MPXV M1R

The focused structure of the C-terminal lobe of the human UBR4-KCMF1-Calmodulin complex

CyroEM structure of the complex between Shiga toxin Stx1a B subunit and neutralising Fab fragment of RDS045

MERS-CoV RBD in complex with receptor DPP4

Local refinement of SARS-CoV-2 KP.3.1.1 RBD with BD57-2704 and AB2-122 Fab

apo rat TRPV2, H651S/D654T/N655D

Apo human TRPV2, S651H/T654D/D655N

Apo human TRPV2, wild-type

2-APB bound human TRPV2, S651H/T654D/D655N

2-APB bound rat TRPV2, H651S/D654T/N655D

HIV-1 reverse transcriptase in complex with DNA Aptamer and Incorporated dATP

HIV-1 reverse transcriptase in complex with DNAddG Aptamer and unincorporated ISL-triphosphate

HIV-1 reverse transcriptase (F227C) in complex with DNAddG Aptamer and unincorporated ISL-triphosphate

HIV-1 reverse transcriptase (F227C) in complex with DNAddG Aptamer

HIV-1 reverse transcriptase (F227C) in complex with DNA Aptamer and Incorporated dATP

Structure of Pex8 in complex with peroxisomal receptor Pex5

Dimeric form of the Streptococcus pyogenes nuclease A (SpnA)

Monomeric form of the Streptococcus pyogenes nuclease A (SpnA)

The cryo-EM map of the vacant C. auris ribosome LSU

The cryo-EM map of the structure of C. auris ribosome in complex with Cycloheximide and Geneticin G418 focused on the head of the SSU

The cryo-EM map of the structure of C. auris ribosome in complex with Blasticidin S focused on the body of the SSU

CryoEM structure of Candida auris 80S ribosome in complex with Cycloheximide and Geneticin G418

The cryo-EM map of the vacant C. auris ribosome focused on the head of the SSU

The cryo-EM map of the structure of C. auris ribosome in complex with Blasticidin S LSU

The cryo-EM map of the structure of C. auris ribosome in complex with Cycloheximide and Geneticin G418 LSU

The cryo-EM map of the structure of C. auris ribosome in complex with Blasticidin S focused on the head of the SSU

The cryo-EM map of the structure of C. auris ribosome in complex with Cycloheximide and Geneticin G418 focused on the body of the SSU

The cryo-EM map of the vacant C. auris ribosome focused on the body of the SSU

CryoEM structure of Candida auris 80S ribosome in complex with Blasticidin S

Tti2-Tti1-C

Cryo-EM structure of VGLUT3 in apo state

Tti1-Telo2 complex

mechanosensitive channel MscS from Francisella tularensis, mutant F108A

KP.3 SARS-CoV2 with fab JN-1.6 local refinement

mechanosensitive channel MscS from Francisella tularensis in nanodiscs

Prefusion-stabilized Hendra virus fusion protein in complex with inhibitory nanobody F130

Cryo-EM structure of the kinetoplastid post-catalytic trans-spliceosome (P complex)

Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; compact dimer conformation

Mouse teneurin-3 A1B1 isoform; microphthalmia-associated R2579W mutant; non-compact subunit; particle subtracted

Native Neisseria meningitidis PilQ, N0-domain focused map

Cryo-EM structure of NLRP3 bound to the inhibitor BAL-1516 at 3.06 Ang resolution

Cryo-EM structure of the kinetoplastid trans-spliceosome activated for catalytic step II (C* complex)

Native Neisseria meninigitidis PilQ, Gate Domain focused map

Discodermolide stabilised 14-protofilament microtubule C1 reconstruction

Neisseria meningitidis Native PilQ tetradecamer

Neisseria meningitidis Native PilQ protomer, composite map

Cryo-EM structure of the Arabidopsis thaliana potassium transporter 5 in apo state

Discodermolide stabilised 13-protofilament microtubule C1 reconstruction

Cryo-EM structure of the Arabidopsis thaliana potassium transporter 5 subjected to ATP dialysis

Cryo-EM structure of the Arabidopsis thaliana potassium transporter mutant - H527R, K759H

Cryo-EM structure of the Arabidopsis thaliana potassium transporter mutant - H527R, E565N, K759H

Cryo-EM structure of human Ceramide glucosyltransferase UGCG

Cryo-EM structure of the Arabidopsis thaliana potassium transporter 5 mutant - H527A

Cryo-EM structure of the Arabidopsis thaliana potassium transporter mutant - H527R, E565N, K759H, K778E, E734K

Cryo-EM structure of the Arabidopsis thaliana potassium transporter 5 purified in the presence of NaCl and ATP

Cryo-EM structure of the Arabidopsis thaliana potassium transporter mutant - K759A

Cryo-EM structure of the Arabidopsis thaliana potassium transporter 5 incubated with AMPPNP

Cryo-EM structure of human UGCG bound to Ibiglustat

Cryo-EM structure of human UGCG bound to UDP and C6-ceramide

Cryo-EM structure of human UGCG bound to Eliglustat

Cryo-EM structure of human UGCG bound to UDP-Glucose

Cryo-EM structure of human UGCG bound to UDP-glucose and a phospholipid

Cryo-EM structure of human UGCG bound to Miglustat

PC-Int1 + 13H11-Fab + 2C12-Fab + 7I13-Fab

Cryo-EM structure of human UGCG bound to UDP

Cryo-EM structure of the Mycobacterium tuberculosis C- 70S ribosome bound to fMet-tRNA(fMet) and deacylated tRNA at ribosome P and E sites

Focused refinement map of IHF region of IF3-a transposase complex with synapsed ends

Chimeric (human-yeast) Sec complex bound to coibamide A

Cryo-EM structure of the ribosome-tunnel occluding hibernation factor bound to Mycobacterium tuberculosis C- 70S ribosome

Consensus map of the IF-3a transposase complex with synaptic ends

The cryo-EM structure of the periplasmic chaperone Skp from Neisseria meningitidis

Composite map of IF-3a transposase complex with paired transposon ends

Cryo-EM structure of the ribosome-tunnel occluding hibernation factor bound to the Mycobacterium tuberculosis C- 70S ribosome carrying an E-tRNA

Cryo-EM structure of the ribosome-tunnel occluding hibernation factor bound to the Mycobacterium tuberculosis C- 50S ribosomal subunit

Cryo-EM structure of the ribosome-tunnel occluding hibernation factor bound to the Mycobacterium tuberculosis C- 70S ribosome carrying fMet-tRNA(fMet) and deacylated tRNA at ribosome P and E sites.

Cryo-EM structure of the MPY and ribosome-tunnel occluding hibernation factors bound to the Mycobacterium tuberculosis C- 70S ribosome

Focused refinement map of distal right end DNA region within IF3A transposase complex with synapsed ends

Focused refinement of core region of 1F3A transposase complex with synapsed ends

Rabbit Psoas Skeletal Muscle Thick Filaments

the structure of ERMA Mg2+ bound form

the structure of ERMA complex with ATPrS and Mg++

E. coli RNA polymerase elongation complex containing the unnatural dZ:PTP base pair in a trigger-loop-closed conformation

Symmetry relaxed reconstruction of Rhodospirillum rubrum encapsulin:encapsulated ferritin nanocompartment

GABA-A a4b3d receptor in complex with DS2-Me, GABA, Nb24 and Mb30

GABA-A a4b3d receptor in complex with GABA and Nb24

Structure of a GPCR dimer bound to two G proteins

Single particle reconstruction of Rhodospirillum rubrum encapsulated ferritin in encapsulin nano compartment

GABA-A a4b3d receptor in complex with GABA, Nb24 and Mb30

Drebrin actin binding domain 1 conformation A (ABD1a) bound to F-actin

Drebrin actin binding domain 2 bound to F-actin

Drebrin actin binding domain 1 conformation B (ABD1b) bound to F-actin

8 nm Cartwheel Subunit from Trichonympha spp.

8 nm Cartwheel Central Hub from Trichonympha spp.

Structure of the HPII Catalase from Escherichia coli

16nm Microtubule Triplet from Trichonympha spp.

16 nm Cartwheel Subunit from Trichonympha spp.

16nm Cartwheel Central Hub from Trichonympha spp.

Cryo-EM structure of a chemically treated Cyanobacterial Photosystem I core with bound platinum nanoparticles

Rabbit 80S with eEF2,CCDC124,and LARP1,40S-head-swiveled

Rabbit 60S ribosomal subunit with eEF2 domain IV closed

Rabbit 80S with eEF2,IFRD2 and LARP1,40S-head-swiveled

Rabbit 60S ribosomal subunit with eEF2 domain IV open

Rabbit 80S with eEF2,eIF5A and SERBP1

Rabbit 80S with IFRD2 and LARP1, 40S head-swiveled

C-His tagged YghJ protein substrate-accessible state

YghJ protein zymogen-like autoinhibited state

SARS-CoV-2 SL5 rotated junction

N-His tagged YghJ protein substrate-accessible state

Cryo-EM structure of the UnCas12m4a-crRNA-tgDNA ternary complex in the NTS-cleaving state

Cryo-EM structure of the TfCas12m3-crRNA-tgDNA ternary complex

Structure of fimbriae-like lipoprotein by Cryo Electron Microscopy

Cryo-EM structure of the UnCas12m4a-crRNA-tgDNA ternary complex in the TS-cleaving state

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4

Structure of mouse full-length LRRC8D

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 1

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 2

u-VT II tau filament from VT Case 3

u-VT Ia tau filament from VT Case 2

Cryo-EM map of SKM-70S complex State 7 (Empty, rotated)

Cryo-EM map of SKM-70S complex State 6 (Empty, canonical)

u-VT Ie tau filament from VT Case 3

Cryo-EM map of SKM-70S complex State 2 (Accommodating A-tRNA)

VT IV tau filament from VT Case 2

u-VT Ib tau filament from VT Case 1

u-VT IV tau filament from VT Case 3

VT II tau filament from VT Case 1

u-VT Ic tau filament from VT Case 1

VT Ia tau filament from VT Case 1

Cryo-EM map of SKM-70S complex State 4 (Accommodated A-tRNA)

u-VT IV tau filament from VT Case 1

u-VT II tau filament from VT Case 1

Xenopus KCNQ1 in complex with UCL2077

Xenopus KCNQ1 Intermediate State (E1R/R2E) in complex with UCL2077

Proteinase K filament

The focused structure of the N-terminal lobe of the human UBR4

Rad55-Rad57-SHU

"Rad55-Rad57-SHU-Rad51 - Composite map

Rad55-Rad57-SHU - Composite map

u-AD PHF tau filament from AD Case 2

AD SF tau filament from AD Case 1

AD SF tau filament from AD Case 2

Rad55-Rad57-SHU bound to ssDNA with AMP-PNP. Local map focused on 55/57

VT V tau filament from VT Case 2

VT Ia tau filament from VT Case 2

VT III tau filament from VT Case 1

Rad55-Rad57-SHU-Rad51

VT V tau filament from VT Case 1

u-VT Ie tau filament from VT Case 1

u-VT V tau filament from VT Case 1

u-VT IV tau filament from VT Case 2

u-VT If tau filament from VT Case 1

u-VT II tau filament from VT Case 2

Native flagellar filament from Leptospira biflexa

Native flagellar filament from Leptospira interrogans flaB1- KO mutant strain

Native flagellar filament from Leptospira interrogans

AD PHF tau filament from AD Case 1

AD PHF tau filament from AD Case 2

VT II tau filament from VT Case 3

VT IV tau filament from VT Case 1

VT II tau filament from VT Case 2

VT Ia tau filament from VT Case 3

u-AD PHF tau filament from AD Case 1

VT IV tau filament from VT Case 3

u-VT Id tau filament from VT Case 1

u-AD SF tau filament from AD Case 2

u-AD SF tau filament from AD Case 1

u-VT III tau filament from VT Case 1

u-VT PHF tau filament from VT Case 1

u-VT V tau filament from VT Case 2

u-VT Ie tau filament from VT Case 2

MPXV replisome bound to ssDNA

MPXV replisome bound to forked DNA

MPXV polymerase-E5 primase core complex

amyloid fibril of recombinant transforming growth factor beta induced protein FAS1-4 domain with V624M mutation

amyloid fibril of recombinant transforming growth factor beta induced protein FAS1-4 domain with V624M mutation, refined using helical spacing of peripheral globular domain

Structure of Measles virus fusion protein in pre-fusion in complex with neutralizing Fabs MeV-15 and MeV-104

Structure of GGCX-BGP-Anisindione complex

Rad55-Rad57-SHU homologous recombination complex. Local refinement on Rad55/Rad57

Rad55-Rad57-SHU homologous recombination complex. Local refinement on SHU