Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease

Subtomogram average of GEM-mCherry-nanobody particles on A549 cell membranes

Cryo-EM structure of neddylated CUL2-RBX1-FEM1C-ELOB-ELOC

Local refinement map of the cytoplasmic lattice (CPL) from mouse oocyte at 3.87 angstrom

Cryo-EM structure of transducer in complex with chimeric receptor

A Cryo-EM structure of LA-PTH-PTH1R-V2RT-Beta-arrestin1 complex (state 1 conformation)

Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease

A Cryo-EM structure of LA-PTH-PTH1R-V2R-Beta-arrestin1 complex (state 2 conformation)

Cryo-EM structure of chimeric receptor in complex with transduce

Local refinement map of the cytoplasmic lattice (CPL) from mouse oocyte at 4.15 angstrom

A Cryo-EM structure of LA-PTH-PTH1R-B-arrestin1 complex (state 2 conformation)

cryo-EM structure of lipase/ligand/substrate complex

binary complex of polyP-bound polyphosphate kinase 1 (PPK1)

A Cryo_EM structure of LA_PTH_PTH1R_V2R_Beta_arrestin1 complex(state 2 conformation)

A focused Cryo_EM structure of LA_PTH_PTH1R_V2R_Beta_arrestin1 complex(state 1 conformation)

A focused refinement Cryo_EM structure of A Cryo_EM structure of LA_PTH_PTH1R and V2R_Beta_arrestin1(state 2 conformation)

A Cryo_EM structure of LA_PTH_PTH1R_V2R_Beta_arrestin1 complex(state 1 conformation)

binary complex of ATP-bound polyphosphate kinase 1 (PPK1)

apo form of polyphosphate kinase 1 (PPK1)

human Argonaute-2 R315V/H316A - miR-122 in complex with a fully complementary target

Structure of human serotonin transporter bound to small molecule zPZd in lipid nanodisc and NaCl

Locally-refined Mu-Opioid Receptor bound with novel compound 0505

Pointed end of Cofilin-2 Bound F-actin

Barbed End of Cofilin-2 F-actin, B0 and B-1 Unoccupied

Barbed End of Cofilin-2 F-actin, B-1 Occupied

One CAP-1 Bound to the Pointed End of Cofilin F-actin

One CAP-1 Bound to the Pointed End of F-actin

Two CAP-1 Bound to the Pointed End of Cofilin F-actin

Two CAP-1 Bound to the Pointed End of F-actin

Barbed End of Cofilin-2 F-actin, Terminal Actins Occupied with Cofilin

Capping protein bound to the barbed end of F-actin

Rhesus rotavirus (consensus structure at 4.7 Angstrom resolution from cryo-ET)

M4-CTD-undocked AP-4 core in apo form

M4-CTD-docked AP-4 core in apo form

Surface Tubular Element of Vaccinia Virus

ARF1(Q71L) bound M4-CTD-docked AP-4 core

ARF1(Q71L) bound M4-CTD-undocked AP-4 core

native AMPA receptors from cerebellum

GluA1/GluA4 ATD binding with 1D8 Fab

Native GluA1/GluA4-CNIH3 complex in resting state

Cryo-EM structure of human dopamine transporter in complex with centanafadine

Structure of Csm6 from Actinomyces procaprae in complex with cyclic penta-adenylate

native AMPA receptors from cerebellum

Native GluA1/GluA4-CNIH3 complex in desensitized state

native AMPA receptors from cerebellum

native AMPA receptors from cerebellum

Cryo-EM structure of human dopamine transporter in complex with tesofensine

Native GluA1/GluA4-CNIH3 complex in active state

Cryo-EM structure of human dopamine transporter in complex with nefazodone

Cryo-EM structure of human dopamine transporter in complex with dasotraline

Cryo-EM structure of human dopamine transporter in complex with ansofasine

Native GluA1/GluA4 AMPA receptor in resting state

Native GluA1/GluA4 ATD dimer binding with 1D8 and 11B8

Tetrahymena Ribozyme L-16 complex with small molecule inhibitor ZPT-084

Structure of TolQRA complex at pH 5.4 from E.coli

Structure of TolQRA complex at pH 8.0 from E.coli

Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targetingTM1/2/4 and GEM targeting TM3/4/5, and agonist-positive allosteric GEM targeting TM5/6/7

native AMPA receptors from cerebellum

Cryo-EM structure of D1R-Gs in complex with de novo designed agonist-positive allosteric GEM targeting TM5/6/7

Octamer Msp1 from S.cerevisiae (with a catalytic dead mutation) in complex with an unknown peptide substrate

native AMPA receptors from cerebellum

Cryo-EM structure of D1R in complex with de novo designed negative allosteric GEM targeting TM5/6/7

Structural insights into photosystem I complex of Bryopsis corticulans

Cryo-EM structure of D1R in complex with de novo designed GEM targeting TM1/2/4 and GEM targeting TM3/4/5, and negative allosteric GEM targeting TM5/6/7

Cryo-EM structure of the SARS-CoV-2 spike protein in complex with S416

Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targeting TM1/2/4

Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targeting TM3/4/5

antibody 20G5 Fab in complex with human B7-H3 (IgC)

Nonamer Msp1 from S.cerevisiae (with a catalytic dead mutation) in complex with an unknown peptide substrate

Cryo-EM structure of the agmatine-bound zTAAR13d-Gs complex

Cryo-EM structure of Bombesin receptor type-3 bound to oridonin

Cryo-EM structure of the cadaverine-bound zTAAR13d-Gs complex

Cryo-EM structure of the histamine-bound zTAAR13d-Gs complex

antibody 20G5 (Fab')2 in complex with human B7-H3

Structure of Csm6 from Actinomyces procaprae

Structure of Csm6 from Actinomyces procaprae in complex with cyclic hexa-adenylate

Cryo-EM structure of the putrescine-bound zTAAR13d-Gs complex

Decamer Msp1 from S.cerevisiae(with a catalytic dead mutation) in complex with an unknown peptide substrate

Cryo-EM structure of the cadaverine-bound zTAAR13c-Gs complex

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 5500 micrographs)

CPS secretion pathway Wza-Wzc (Conf 3)

Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb11

CPS translocon Wza_C8

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 2500 micrographs)

Apo-MtbKu , not bound to DNA

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 7500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 11594 micrographs)

CPS secretion pathway Wza-Wzc_C1 (Conf 0)

CPS co-polymerase Wzc_C1

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 4500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 11500 micrographs)

structure of two human ELF2 transcription factors in complex with a nucleosome

Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 1 up & 2 down) bound to RBD-targeting MO176-117 antibody

Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb4

CryoEM map of Intermediate 2 of SARS-CoV-2 spike protein (from revitrified dataset)

Cryo-EM consensus map of prefusion SARS-CoV-2 spike (RBDs: 1 up & 2 down) bound to RBD-targeting MO176-117 antibody

DNA-PK, LX4, XLF - Catalytic domain of L4

CryoEM map of Intermediate 3 of SARS-CoV-2 spike protein (from revitrified dataset)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 10500 micrographs)

CryoEM map from 60 microseconds revitified sample of SARS-CoV-2 spike protein

CryoEM map of Intermediate 5 of SARS-CoV-2 spike protein (from revitrified dataset)

CryoEM map of Intermediate 4 of SARS-CoV-2 spike protein (from revitrified dataset)

Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 2 up & 1 down) bound to RBD-targeting MO176-117 antibody

Cryo-EM Structure of Self-assembled Zymomonas mobilis Levansucrase Nanotube

PhiC31 S12A dimer on attB sites

Nitrogenase maturase NifEN in complex with the cofactor chaperone NifX

CryoEM map from 30 microseconds revitified sample of SARS-CoV-2 spike protein

Nitrogenase maturase NifEN

Cryo-EM consensus map of prefusion SARS-CoV-2 spike (RBDs: 2 up & 1 down) bound to RBD-targeting MO176-117 antibody

Ex vivo spore-silk A-ENA fibers

CPS translocon Wza_C1

CPS co-polymerase Wzc_C4

CPS secretion pathway Wza-Wzc_C8 (Conf 0)

CPS secretion pathway Wza-Wzc_C1 (Conf 2)

CPS secretion pathway Wza-Wzc_C1 (Conf 1)

CPS secretion pathway Wza-Wzc_C8 (Conf 1)

CPS secretion pathway Wza-Wzc_C8 (Conf 2)

CPS secretion pathway Wza-Wzc (Conf 4)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 6500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 8500 micrographs)

CPS secretion pathway Wza-Wzc (Conf 5)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 3500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 9500 micrographs)

Retron-Eco8 complex with ATP-Mg2+

Subtomogram average of nucleosomes extracted from vitreous sections of Drosophila melanogaster embryos

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Escherichia coli ribosome arrested on a chimeric, 130-residue construct featuring a firefly-luciferase truncation followed by SecM(3W)

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Escherichia coli ribosome arrested on a chimeric, 190-residue construct featuring a firefly-luciferase truncation followed by SecM(3W)

Escherichia coli ribosome arrested on a chimeric, 110-residue construct featuring a firefly-luciferase truncation followed by SecM(3W)

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Uncrosslinked hClpXP composite map

Scaffold attached to quinine-I aptamer (Tonic) local refinement of aptamer

RNA scaffold attached to 8-oxoguanine riboswitch aptamer, combined core plus aptamer

Scaffold attached to quinine-I aptamer (Tonic) local refinement of core

Scaffold attached to quinine-I aptamer (Tonic) refinement of aptamer and core

Reconstruction of the intranuclear varicella-zoster virus capsid.

Reconstruction of the intracellular varicella-zoster virus capsid with portal.

Reconstruction of the varicella-zoster virus capsid vertex.

VZV portal vertex cryo-ET reconstruction.

VZV portal cryo-ET reconstruction.

Reconstruction of intracellular varicella zoster virus CAI-capsid with portal.

Reconstruction of the varicella-zoster virus C-capsid with the portal vertex.

Reconstruction of the portal vertex from intracellular varicella-zoster virus CAI-capsids.

CP at the barbed end with one cofilin on second-to-last subunit

hClpP with DM

VZV C-capsid portal vertex.

Capping protein bound to the barbed end of cofilactin

Cofilactin filament

Un-crosslinked hClpXP

2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: RBD-aptamer)

RNA scaffold attached to disordered U1A stem loop

Scaffold attached to Mango without ligand, local refinement of core, tilted data collection of tetramer

Focus-refined map of C. elegans piezo channel

RNA scaffold attached to 8-oxoguanine riboswitch aptamer Glacios data

Scaffold attached to Mango without ligand, local refinement of aptamer, tilted data collection of tetramer

Yeast V1-ATPase bound to Rtc5p

Cryo-EM structure of the CHSY3-CHPF1 chondroitin synthase heterodimer

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-ACT-2

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-Primed, AHD-Sorted

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-ACT-3

RNA scaffold

RNA scaffold attached to Mango in the absence of ligand

RNA scaffold attached to tRNA

RNA scaffold

RNA scaffold attached to 8-oxoguanine riboswitch core Glacios data

RNA scaffold attached to 8-oxoguanine riboswitch aptamer core only

Artemia ferritin cell-free expression with reverse his purification

RNA scaffold attached to 8-oxoguanine riboswitch aptamer

RNA scaffold attached to Mango in the presence of TO1-biotin

Human 80S ribosome stalled on MYC nascent chain

Human 80S ribosome bound to IDB-002 stalled on FPAK-containing nascent chain

Artemia ferritin from cell-free lysate

Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain

Structure of the MOR/Gi/Mitragynine Pseudoindoxil Complex, GTP-bound G-Primed, Consensus Refinement

Structure of the MOR/Gi/Mitragynine Pseudoindoxil Complex, GTP-bound G-ACT-2/3 Consensus Refinement

Structure of the MOR/Gi/DAMGO Complex, Nucleotide Free, Baseline

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-Primed

Cryo-EM Map of the FtsH.HflK/C Complex Solubilized in DDM from Tobramycin-Treated Cells

Cryo-EM map of the FtsH.HflK/C membrane assembly extracted in carboxy-DIBMA from tobramycin-treated cells

Cryo-EM structure of the engineered HflK/C variant stabilized in the closed conformation via disulfide bond crosslinking.

ABCE1-eRF1-RNC-AMD1C

DX2-CX3-RAD51 structure in the intermediate state

DX2-CX3-RAD51 in the closed state

BCDX2-CX3-RAD51-RAD51-ssDNA supercomplex

DX2-CX3-RAD51 in the active state

DX2-CX3 structure capping RAD51 filament

Cryo-EM structure of the type VII CRISPR-Cas14 effector complex

In situ cryo-electron tomogram of 4days rpn9 surface mutant nucleus

In situ cryo-electron tomogram of 4days glucose 1h WT nucleus

In situ cryo-electron tomogram of 18h nucleus

In situ cryo-electron tomogram of 4days glucose control WT nucleus

In situ cryo-electron tomogram of 4days WT cytoplasm 3

In situ cryo-electron tomogram of SA 1day WT cytoplasm 2

In situ cryo-electron tomogram of SA 1day WT cytoplasm 1

In situ cryo-electron tomogram of 4days rpn9deltaN nucleus

100 kV cryo-EM structure of apoferritin at 1.91 A with DECTRIS SINGLA detector on CRYO ARM 200 II

Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1G1

In vitro cryo-electron tomogram of 4days WT purified

In situ cryo-electron tomogram of 4days mlp1delta mlp2delta nucleus

Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1B2

Inward-occluded structure of human GABA transporter 3 bound to substrate GABA

2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: PXT origami 'pointer')

In situ structure of the open-linker H1-bound nucleosome

2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: Spike core)

3-helix origami tile + Broccoli and Pepper aptamers (3HT-BP) with 2'-Fluoro-modified pyrimidines (FY RNA)

2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: Spike N-terminal domain (NTD))

2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (Full map, no symmetry)

Cryo-EM structure of mouse heavy-chain apoferritin at 1.24 A on CRYO ARM 200 II

CryoEM structure of delta opioid receptor bound to G proteins and met-enkephalin

CryoEM structure of delta opioid receptor bound to G proteins and Naltrindole

CryoEM structure of delta opioid receptor bound to G proteins and naltrexone

CryoEM structure of delta opioid receptor bound to G proteins and ADL5859

CryoEM structure of delta opioid receptor bound to G proteins and SNC80

Human PARP1 N-terminal domains bound to nicked DNA

CryoEM structure of stabilized dengue 3 virus envelope glycoprotein in complex with Fab of F25.S01

In situ structure of the cardiac thin filament without troponin from MYH7(WT/G256E) human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-141 ACTN2-mEGFP MYH7(WT/G256E))

In situ structure of the cardiac thin filament without troponin from isogenic control human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-113 ACTN2-mEGFP MYH7(WT/WT))

In situ structure of the cardiac thin filament without troponin from untreated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)

In situ structure of the cardiac thin filament with troponin from MYH7(WT/G256E) human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-141 ACTN2-mEGFP MYH7(WT/G256E))

In situ structure of the cardiac thin filament without troponin from doxorubicin-treated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)

In situ structure of the cardiac thin filament with troponin from untreated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)

In situ structure of the cardiac thin filament with troponin from isogenic control human induced pluripotent stem cell-derived cardiomyocytes (AICS-0097-113 ACTN2-mEGFP MYH7(WT/WT))

AZD-3 bound EFPA transporter of Mycobacterium tuberculosis

ln situ structure of the cardiac thin filament with troponin from doxorubicin-treated human induced pluripotent stem cell-derived cardiomyocytes (SCVI-273)

HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R

Capsid Subtomogram Average From NL4.3:PR(D25N) Immature HIV-1 Virions

HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R

Globally refined map of odorant-bound mouse class II odorant receptor G protein complex

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the pre-strand exchange state

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the pre-strand exchange state (attB-R)

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the pre-strand exchange state (attP-R)

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the post-strand exchange state

2.62A cryo-EM structure of RNA-directed RNA polymerase L of Crimean-Congo hemorrhagic fever virus (Apo state)

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (CA/CA CDN) in the intermediate-strand exchange state 1

The structure of odorant-bound mouse class II odorant receptor-miniGs complex

P ring on polyrod-P ring complex from Salmonella TH26292 strain

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the pre-strand exchange state (attB-L)

Receptor-focused map of odorant-bound mouse class II odorant receptor G protein complex

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (CA/CA CDN) in the intermediate-strand exchange state 2

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (GT/TT CDN) in the pre-strand exchange state (attP-L)

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (CA/CA CDN) in the pre-strand exchange state

Cryo-EM structure of the large serine recombinase Bxb1 in complex with attP and attB (CA/CA CDN) in the post-strand exchange state

2.53A cryo-EM structure of RNA-directed RNA polymerase L of Crimean-Congo hemorrhagic fever virus (RNA bound)

Gut transporter with sorbitol

Yeast-expressed polio type 1 stablized virus-like particles with 3G10 Fab

Yeast-expressed polio type 1 expanded virus-like particles

Yeast-expressed polio type 1 stabilized virus-like particles

GFP bound to distal DARPin (AHIR dodecamer scaffold system from split dataset with 1500 micrographs)

GFP bound to distal DARPin (AHIR dodecamer scaffold system)

Cryo-EM structure of mouse Pannexin 1 in complex with a ligand

the complex of D14 and RGSV P3

Human Stomatin - intramembrane region

Cytochrome bd II oxidase qOR-2 type from Mycobacterium smegmatis

The cryo-EM structure of NmTbpA and NmTbpB in a complex

Ecoli DnaB helicase and Phage Lambda loader P with ADP-Mg in a 6:5 stoichiometry ratio

Transferrin Binding Protein A in complex with transferrin binding protein B and two molecules of transferrin

Transferrin Binding Protein A in complex with transferrin binding protein B and transferrin (iron bound in both lobes of Tf)

Cryo-EM structure of human ATP citrate lyase in complex with inhibitor EVT0185-CoA

Neisseria gonorrhoeae Transferrin Binding Protein A in complex with Transferrin Binding Protein B and transferrin (iron bound in N lobe only)

Transferrin Binding Protein A

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-2/3, Global and G Protein Local

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-2', G Protein Local

S.c INO80 in complex with Yeast 0/80 nucleosome, Apo State

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-2, G Protein Local

Transferrin Binding Protein A in complex with transferrin binding protein B, transferrin and globular domain of TonB

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-1

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-2/3, Global 3DVA Sorted 1

NmTbpB and Tf protein complex

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-ACT-2/3, Global 3DVA Sorted 2

Structure of the MOR/Gi/Lofentanil Complex, GTP-bound G-Primed

Structure of the MOR/Gi/Lofentanil Complex, Nucleotide Free

Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease

Local refinement map of the cytoplasmic lattice (CPL) from mouse oocyte at 3.90 angstrom

Local refinement map of the cytoplasmic lattice (CPL) from mouse oocyte at 3.94 angstrom

Cryo-EM structure of human papillomavirus type 45

Tetrahymena Ribozyme L-16 inhibited state

Local refinement map of the cytoplasmic lattice (CPL) from mouse oocyte at 3.81 angstrom

Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease