EMD-65893

Single-particle
2.57 Å
EMD-65893
3D View Gallery
Deposition: 19/08/2025
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65893

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9wdo summary report (pdf.gz) Map-9wdo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the human PKR tetramer with mitapivat (C2 symmetric, dual-bound state)

EMD-65893

Single-particle
2.57 Å
EMD-65893
3D View Gallery
Deposition: 19/08/2025
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of the human PKR tetramer with mitapivat (C2 symmetric, dual-bound state)
Fitted models: 9wdo

Deposition Authors: Ma HY, Su ZM

Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists
Ma HY, Su ZM
To Be Published