EMD-59343
Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-4
EMD-59343
Single-particle2.4 Å
Deposition: 09/08/2026Map released: 26/08/2026
Last modified: 26/08/2026
Sample Organism:
Homo sapiens,
Mus musculus
Sample: MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-6
Fitted models: 33ch
Deposition Authors: Schuster S
,
Weng T-H,
Reinhart C ,
Michel H ,
Birkenfeld J
Sample: MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-6
Fitted models: 33ch
Deposition Authors: Schuster S
,
Weng T-H,
Reinhart C ,
Michel H ,
Birkenfeld J
Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
Schuster S ,
Hartl FA ,
Stehle J,
Beier F,
Al-Hasani H ,
Reinhart C ,
Weng T-H,
Kraemer S ,
Hamde P,
Herz T ,
Oesterlin S,
Schmidt M,
Gross T,
Stehl L,
Kilb N ,
Juenemann G,
Heiss K,
Sinclair A,
Schoettgen J,
Meyer P,
Atay B,
Zaghla BKQ,
Link S,
Goll J,
Leoni B,
Steinmann B,
Selinger O ,
Welsch S ,
Roth G,
Michel H ,
Klatt M ,
Birkenfeld J
To Be Published
,
Hartl FA ,
Stehle J,
Beier F,
Al-Hasani H ,
Reinhart C ,
Weng T-H,
Kraemer S ,
Hamde P,
Herz T ,
Oesterlin S,
Schmidt M,
Gross T,
Stehl L,
Kilb N ,
Juenemann G,
Heiss K,
Sinclair A,
Schoettgen J,
Meyer P,
Atay B,
Zaghla BKQ,
Link S,
Goll J,
Leoni B,
Steinmann B,
Selinger O ,
Welsch S ,
Roth G,
Michel H ,
Klatt M ,
Birkenfeld J
To Be Published
Grant Support:
- Max Planck Society: (Germany)