EMD-72097

Single-particle
3.02 Å
EMD-72097
3D View Gallery
Deposition: 12/08/2025
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72097

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q0f summary report (pdf.gz) Map-9q0f FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of angiotensin II type 1 receptor bound to a b-arrestin biased allosteric modulator stabilized by a synthetic nanobody

EMD-72097

Single-particle
3.02 Å
EMD-72097
3D View Gallery
Deposition: 12/08/2025
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Homo sapiens
Sample: AT1R and Nanobody AT110i1 complex occupied by the orthosteric ligand TRV023 and the allosteric modulator Cmpd-23
Fitted models: 9q0f

Deposition Authors: Liu S, Peng X, Pakharukova N, Ahn S, Lefkowitz RJ

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules
Liu S, Xiao P, Elgeti M, Fine EJ, Lucero EY, Vestergaard M, Wang J, Jyothidasan A, Angus L, Qu C, Olsen E, Mazis G, Madsen JK, Suomivuori C-M, Kim J, Pakharukova N, Rahman R, Kereliuk SM, Koch W, Strachan RT, Staus DP, Masoudi A, Hubbell WL, Kahsai AW, Dror RO, Rockman HA, Sun J-P, Ahn S, Lefkowitz RJ
To Be Published