SARS-CoV-2 RNA-dependent RNA polymerase in complex with 4'-FlA nucleotide analogue

Cryo-EM map of Ascl1-E12a in complex with NRCAM nucleosome without scFv

CryoEM structure of AdhE spirosome from Clostridium thermocellum uncovered by visual proteomics.

Cryo-EM structure of human CD33 bound to 15G15.3 Fab

Cryo-electron microscopy structure of PfRIPR bound to monoclonal antibodies RP.093, RP.073 and RP.063

Cryo-electron microscopy structure of PfRIPR bound to monoclonal antibodies RP.047, RP.057 and RP.035

Cryo-electron microscopy structure of PfRIPR bound to monoclonal antibodies RP.092 and RP.052

Babesia divergens ribosome structure by single-particle cryo-EM (3D class1, A-, P-, and E-site tRNAs and mRNA)

Electron tomogram of the postmitotic nuclear envelope following acute Nup62 depletion

cryo-EM map of CH31 IgM BCR receptor representing immunoglobulin ectodomain, population 2

cryo-EM map of CH31 IgM BCR receptor representing immunoglobulin ectodomain, population-1

cryo-EM structure of CH31 IgM BCR lacking view of Fab region

Cryo-EM map of 2G12 IgG BCR ectodomain, Population 2

Cryo-EM map of 2G12 IgG BCR ectodomain, Population 3

Cryo-EM map of 2G12 IgG BCR ectodomain, Population 1

Cryo-EM map of 2G12 IgG BCR lacking Fab region view

Cryo-EM map of CH31 IgM BCR receptor representing immunoglobulin ectodomain, population 3

In situ cryo-ET analysis of mitochondria and autophagosome contact in tauP301S Tg mouse cortical neurons

In situ cryo-ET analysis of mitochondria and autophagosome contact in tauP301S Tg mouse cortical neurons Supplementary 1

In situ cryo-ET analysis of mitochondria and autophagosome contact in tauP301S Tg mouse cortical neurons Supplementary 2

Human 80S ribosome bound to small molecule SW393071

Transport and inhibition mechanisms of human glycine transporter 2

The structure of glycine transport 2 in apo state

In situ subtomogram average of Hodarchaeales HC1 actin filament

The structure of glycine transport 2 in complex with glycine

Transport and inhibition mechanisms of human glycine transporter 2

Reduced E.coli aerotaxis receptor

Oxidized E.coli aerotaxis receptor in MH-cap free state

Structure of human Trpm4 in native lipid vesicles at 8 degrees celsius

Cryo-EM structure of macaque red cone pigment with Q114N mutation

Cryo-EM structure of macaque green cone pigment wild type

Cryo-EM structure of macaque green cone pigment with Q114N mutation

Averaged protofilament of Heimdallarchaeales alpha/beta tubulin microtubule with a single seam

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Rrp12-A2

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Tsr1-1

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state Rrp12-A1**

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Tsr1-2

Cryo-EM structure of the 90S pre-ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state A

Cryo-EM structure of the 90S pre-ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state B1

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Rrp12-A1

Cryo-EM structure of the 90S pre-ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state B1*

Cryo-EM structure of the 90S pre-ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state a

Cryo-EM structure of the 90S pre-ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state B1

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state Tsr1-1*

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 Mut ) from Chaetomium thermophilum, state Rio2-C*

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Tsr1-3

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 Mut) from Chaetomium thermophilum, state Rrp12-A1*

Cryo-EM structure of the pre-40S ribosome (Enp1-Rrp12 WT) from Chaetomium thermophilum, state Rio2-C

EV-D68 in complex with G12 VHH

Consensus map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class1, A-, P-, and E-site tRNAs and mRNA)

Multi-body SSU body map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class1, A-, P-, and E-site tRNAs and mRNA)

Multi-body LSU map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class1, A-, P-, and E-site tRNAs and mRNA)

Multi-body SSU head map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class1, A-, P-, and E-site tRNAs and mRNA)

Consensus map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class3, E-site tRNA)

Cryo-EM local map of 2 VRC35 Fabs bound to HIV-1 BG505 DS-SOSIP.664 Env trimer

Multi-body LSU map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class3, E-site tRNA)

nucleosome containing histone variant macroH2A

Cryo-EM map of 12 VRC35 Fabs bound to HIV-1 Env trimer

Cryo-EM local map of 4 VRC35 Fabs bound to HIV-1 BG505 DS-SOSIP.664 Env trimer

Multi-body SSU head map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class3, E-site tRNA)

Multi-body SSU body map for Babesia divergens ribosome structure by single-particle cryo-EM (3D class3, E-site tRNA)

Open Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic) with an open active site (open TL and RH-FL)

SemiClosed Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic) with a semiclosed active site (closed TL, open RH-FL)

CBR9379 bound Open1 Eco-ePEC: Cryo-EM structure of Eco RNAP his-elemental paused elongation complex with an open active site (open TL, SI3 and RH-FL)

AAP-SO2 bound Open Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic) with an open active site (open TL and RH-FL)

Closed Mtb-EC: Cryo-EM structure of Mtb RNAP elongation complex (substrate loading mimic) with a closed active site (closed TL and RH-FL)

CBR9379 bound Open2 Eco-ePEC: Cryo-EM structure of Eco RNAP his-elemental paused elongation complex with an open active site (open TL, SI3 and RH-FL)

SemiClosed Eco-ePEC: Cryo-EM structure of Eco RNAP his-elemental paused elongation complex with a semi-closed active site (closed TL and SI3, open RH-FL)

Structure of yeast Pol II in complex with a cisplatin-induced inter-strand crosslink lesion at the +7 position.

Structure of mammalian RNA polymerase II stalled by a cisplatin-induced inter-strand crosslink lesion at the +2 position.

Structure of yeast Pol II in complex with a short control scaffold lacking cisplatin-ICL lesion.

Structure of yeast Pol II complexed with a longer scaffold containing a cisplatin-induced inter-strand crosslink at the + 3 position.

Structure of yeast Pol II in complex with a longer scaffold containing a cisplatin-ICL lesion at +7 position.

Structure of yeast Pol II complexed with a longer scaffold containing a cisplatin-induced inter-strand crosslink at the + 2 position.

Structure of yeast Pol II-Elf1 complex containing a cisplatin-ICL lesion at +7 position.

Structure of pre-translocation state of yeast Pol II complexed with a cisplatin-induced inter-strand crosslink at the +2 position.

Structure of post-translocation state of yeast Pol II complexed with a cisplatin-induced inter-strand crosslink at the +2 position.

Structure of backtracked yeast Pol II in complex with a cisplatin-induced inter-strand crosslink lesion at the +2 position.

Structure of yeast Pol II complexed with a longer scaffold containing a cisplatin-induced inter-strand crosslink lesion at the +5 position.

Structure of yeast Pol II in complex with a longer control scaffold lacking cisplatin-ICL lesion.

Structure of yeast Pol II in complex with an oxaliplatin-ICL lesion at +7 position.

Structure of yeast Pol II in complex with an oxaliplatin-ICL lesion at +2 position.

Structure of yeast post-translocation state Pol II in complex with a cisplatin-ICL lesion at +2 position in the second ICL DNA sequence.

Structure of yeast pre-translocation state Pol II in complex with a cisplatin-ICL lesion at +2 position in the second ICL DNA sequence.

HIV-1 Gag (CASP1NCSP2p6) assembled with core encapsidation signal - tomography map

HIV-1 Gag (CASP1NCSP2p6) assembled with dimerization signal - tomography map

The complex of A1AT-NHK with the ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).

HIV-1 Gag (CASP1NCSP2p6) assembled with core encapsidation signal - C6 symmetry

HIV-1 Gag (CASP1NCSP2p6) assembled with core encapsidation signal - C1 symmetry

Vpb4Aa2 pore complex in C7 symmetry

Apoferritin with crossed laser phase plate (xLPP), xLPP-off, paired dataset

Apoferritin with crossed laser phase plate (xLPP), xLPP-on, paired dataset

Apoferritin with crossed laser phase plate (xLPP), xLPP-on

Evaluating the Volta Phase Plate for Improved Tomogram Alignment in Cryo-Electron Tomography: structure of PP7 virus-like-particle without VPP (full dataset)

Evaluating the Volta Phase Plate for Improved Tomogram Alignment in Cryo-Electron Tomography: structure of PP7 virus-like-particle with VPP (full dataset)

Structure of the kinase and central lobes of human CDK8 kinase module

Structure of the H-lobe of human MED12

Cryo-EM structure of the bacteriophage N4 virion RNA polymerase (closed plug state)

Cryo-EM structure of the bacteriophage N4 virion RNA polymerase (open plug state)

PSI-IsiA Complex from Anabaena 7120

Cryo-EM structure of the bacteriophage N4 virion RNA polymerase (transcription initiation complex)

Babesia divergens ribosome structure by single-particle cryo-EM (3D class3, E-site tRNA)

Locally Refined Cryo-EM map of 2G12 IgG BCR receptor lacking Fab region view

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the pre-cleavage state

Vpb4Aa2 pore complex in C1 symmetry

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the post-cleavage state

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the pre-cleavage state

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the post-cleavage state

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a non-cognate target RNA in the pre-cleavage state

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a non-cognate target RNA in the pre-cleavage state

Caspase-4 p20/p10 and human GSDMD

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state) (CASP target)

Eukaryotic translation initiation factor 2-B in its apo form (inactive-state) (CASP target)

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) (CASP target)

Caspase-4 p22/p10 and human GSDMD complex

Eukaryotic translation initiation factor 2-B in its apo form (active-state) (CASP target)

Eukaryotic translation initiation factor 2-B (eIF2B) bound to the viral effector AcP10

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10 (CASP target)

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) bound to the viral effector AcP10 (CASP target)

GRM1-Acc State Conformation 2

2.3 angstrom cryoEM map of endogenous nucleosome core particle in nuclear lysate

Cryo-EM structure of human Tom70 in complex with Hsp90 C-terminal EEVD peptide

Cryo-EM structure of human Tom70

Subtomogram average of septal junctions from Nostoc PCC7120 FraD-TM

Gephyrin E-Domain dimer of dimers - local refinement of dimer A

Echovirus 18 particle missing three pentamers in situ, symmetrized reconstruction (C3)

Gephyrin E-Domain dimer of dimers - local refinement of dimer B

Gephyrin dimer of dimers - combined CryoEM map

Cryo-EM structure of Gephyrin in complex with Darpin 27F3, revealing linker-E domain interactions

Subtomogram average of septal junctions from Nostoc PCC7120 wild type

Cryo-EM structure of Gephyrin E domain in complex with Darpin 27F3

Gephyrin E-Domain dimer of dimers - Consensus Map

Cryo-electron tomogram of septal region from Nostoc PCC7120 FraD-TM

apo state of CydDC in nanodisc

Structure of echovirus 18, activated particle

Cryo-electron tomogram of septal region from Nostoc PCC7120 FraD-TM

Structure of echovirus 18 in complex with neonatal Fc receptor

Cryo-electron tomogram of septal region from Nostoc PCC7120 wild type

Structure of echovirus 18, empty particle

In situ chromatosome structure from primary human T cells (C2 symmetry applied)

Cryo-EM structure of human apoferritin at 1.81 Angstrom resolution(using CR-BIS data collection on Falcon4).

Cryo-EM structure of human apoferritin at 1.79 Angstrom resolution(using BIS data collection on Falcon4).

In situ subtomogram average of 80S ribosome (local refined with LSU mask)

Cryo-EM structure of human apoferritin at 1.65 Angstrom resolution(using BIS data collection on Falcon4i).

Cryo-EM structure of human apoferritin at 1.64 Angstrom resolution(using CR-BIS data collection on Falcon4i).

Cryo-EM structure of human apoferritin at 2.05 Angstrom resolution(using CR-BIS data collection on K3).

Cryo-EM structure of human apoferritin at 2.05 Angstrom resolution(using BIS data collection on K3).

Subtomogram average structure of human apoferritin at 1.98 Angstrom resolution(using CR-BIS data collection on Falcon4i).

Subtomogram average structure of human apoferritin at 2.24 Angstrom resolution(using CR-BIS data collection on Falcon4).

Subtomogram average structure of human apoferritin at 2.01 Angstrom resolution(using BIS data collection on Falcon4i).

Subtomogram average structure of human apoferritin at 2.28 Angstrom resolution(using BIS data collection on K3).

Subtomogram average structure of human apoferritin at 2.34 Angstrom resolution(using BIS data collection on Falcon4).

Cryo-EM structure of heteromeric Kir4.1/5.1 potassium channel in complex with Ehop-016

Subtomogram average structure of human apoferritin at 2.21 Angstrom resolution(using CR-BIS data collection on K3).

Cryo-EM structure of apo UL9 complex

Cryo-EM structure of MST-OR complex

Cryo-EM structure of UL9-DNA complex

cryo-EM structure of a chimeric EfpA dimer

Structure of ENBT1 in the apo state

CryoET of archaellated cell pole of L. aerophila

CryoET of cell pole of L. aerophila

CryoET of L. aerophila cell

C3 map of the filament formed by the grappling-hook like protein A from L. aerophila

Cryo-EM structure of TRP melastatin channel in the intermediate 2 state

Structure of a membrane-bound inositol phosphorylceramide synthase and Aureobasidin A complex

Cryo-EM structure of TRP melastatin channel with menthol

Cryo-EM structure of TRP melastatin channel with icilin

C1 map of the filament formed by the grappling-hook like protein A from L. aerophila

Cryo-EM structure of TRP melastatin channel in the closed state

In situ chromatosome structure from primary human T cells (C1 symmetry applied)

Cryo-EM structure of TRP melastatin channel in the intermediate 1 state

Molecular mechanism of prostaglandin transporter SLCO2A1

CydDC in nanodisc with AMP-PNP-bound

CydDC in nanodisc with ATP

Cryo-EM structure of TLP-IPT

Cryo-EM Structure of Parabacteroide phage PD491P1 head-to-tail interface

The consensus map of HBx-Smc5/6 ubiquitination complex

Cryo-EM structure of the tail tip region of Parabacteroide phage PD491P1 (imposed with C3 symmetry)

Cryo-EM structure of TLP-2

Cryo-EM structure of TLP-0

CydDC in nanodisc with heme-bound I

Colanic acid polysaccharide related protein structures

Structure of the Choline Transporter BetT under Acidic Conditions

Cryo-EM structure of TLP-3

Cryo-EM structure of the tail tip region of Parabacteroide phage PD491P1 (imposed with C6 symmetry)

CydDC in nanodisc with heme-bound II

Cryo-EM structure of TLP-4b

Colanic acid polysaccharide related protein structures

OmpK35 in complex with bacteriocin KlebG

Dark-state structure of human medium-wave-sensitive cone opsin (OPN1MW)

Pre-active dark-state structure of human short-wave-sensitive opsin (OPN1SW)

OmpK35 in complex with bacteriocin KlebG

Dark-state structure of human short-wave-sensitive opsin (OPN1SW)

Insulin receptor ectodomain in apo-conformation

Insulin receptor ectodomain in complex with s661 insulin mimetic

Cryo-EM structure of the human UAP56-RNA - SAC3D1-PCID2-SEM1 complex

Cryo-EM structure of the human SAC3D1-PCID2-SEM1 complex

Cryo-EM structure of the human LENG8-PCID2-SEM1 complex

CryoEM structure of human 20S proteasome in complex with proteasome inhibitor CP-17

Cryo-EM structure of the human UAP56-RNA - LENG8-PCID2-SEM1 complex

Cryo-EM structure of the human UAP56 NTD - LENG8-PCID2-SEM1 complex

Cryo EM structure of hemagglutinin from Puerto Rico/8/1934 (H1N1) in complex with a single domain antibody

Cryo-EM Structure of Parabacteroide phage PD491P1 Capsid

Cryo EM structure of hemagglutinin from Puerto Rico/8/1934-New York/55/2004 (H3N2) in complex with a single domain antibody

Cryo-EM structure of NSUN2-tRNAlys-SAM

Cryo-EM structure of NSUN2-tRNATyr-SAM

Cryo-EM structure of NSUN2-pre-tRNALeu-SAM

H-ring in Vibrio cholerae at closed state of P-ring

HIV-1 CA hexamer (MX2 bound)

Bacteriophage 812 prohead II without minor capsid proteins

HIV-1 CA tri-hexamer interface

Sheathed flagellar motor structure with C1 symmetry in Vibrio cholerae

HIV-1 capsid tri-hexamer bound to MX2

Unbound HIV-1 CA hexamer

Bacteriophage 812 prohead II with the complete set of minor capsid proteins

C1 symmetry cryoEM structure of the soluble-WRAPed membranous portion of MspA (Mycobacterium smegmatis porin), dimerized along the native interface.

Escherichia coli transcription-translation loosely coupled complex (TTC-LC^walked) containing mRNA with a 39 nt long spacer, NusG, NusA, and fMet-tRNAs in E-site and P-site - Map 1a

Factor XIa in complex with Fab fragment of REGN9933-A2

Factor XIa in complex with Fab fragment of REGN7508-Cat

DnaB complex binding with ssDNA and dTDP-AlFx

Bacteriophage 812 prohead II with minor capsid proteins with partial occupancy

Mitochondrial Creatine Kinase in complex with uncompetitive inhibitor uci

The sharpened consensus map for UL9-ICP8-DNA complex

The focused map for UL9-DNA

The focused map for ICP8-DNA

Free pointed end of F-actin

Cryo-EM structure of F-actin in the ADP state

Local refinement of bottom five actins for One Lmod2 at the pointed end of F-actin

One Lmod2 and incoming actin at the pointed end of F-actin

Consensus map for One Lmod2 at the pointed end of F-actin

Local refinement of Lmod2 and the two terminal pointed end actins for One Lmod2 at the pointed end of F-actin

One Lmod2 at the pointed end of F-actin

Two Lmod2s and incoming actin at the pointed end of F-actin

Consensus map for Two Lmod2s and incoming actin at the pointed end of F-actin

Local refinement of both Lmod2s, incoming actin, and the two terminal pointed end actins for Two Lmod2s and incoming actin at the pointed end of F-actin

Local refinement of the bottom five actins for Two Lmod2s and incoming actin at the pointed end of F-actin