Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor RPI-GLYT2-82

Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor ORG25543

Inward-open structure of human glycine transporter 2 in substrate-free state

Inward-occluded structure of human glycine transporter 2 bound to substrate glycine

A 3D density map of a 2D lattice formed by octahedral DNA origami with 100% loaded ferritin, was revealed by IMOD (Tomo #1).

MBP bound to distal DARPin (AHIR dodecamer scaffold system)

A non-averaged 3D density map of an individual particle, with a 2D lattice formed by octahedral DNA origami and ferritin, was revealed by individual particle cryo-electron tomography (Arm #11 of Particle #001).

A 3D density map of a 2D lattice formed by octahedral DNA origami with 100% loaded ferritin, was revealed by IMOD (Tomo #2).

A non-averaged 3D density map of an individual particle, with a 2D lattice formed by octahedral DNA origami and ferritin, was revealed by individual particle cryo-electron tomography (Arm #09 of Particle #001).

NAC H59-docked barrel: Ribosome nascent chain complex (Oxa1LdelMTS)

A 3D density map of a 2D lattice formed by octahedral DNA origami without ferritin, was revealed by IMOD (Tomo #4).

Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H47 CD19 CAR construct (sample 2)

Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H8 CD19 CAR construct (sample2, region1)

A 3D density map of a 2D lattice formed by octahedral DNA origami with 70% loaded ferritin, was revealed by IMOD (Tomo #3).

Nanotube of Y5 - (5 protomer)

NAC H59-undocked barrel: Ribosome nascent chain complex (Oxa1LdelMTS)

Nanotube of Y5 - (4 protofilament)

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-ACT-2/3 Consensus Refinement

Structure of the MOR/Gi/DAMGO Complex, GTP-Bound, G-ACT-1

Cryo-EM structure of Human Apoferritin at pH 5

Cryo-EM structure of Human Apoferritin at pH 4

Cryo-EM structure of Human Apoferritin at pH 3.5

Cryo-EM structure of Human Apoferritin at pH 9

An auto inhibitory loop in the MiDAC histone deacetylase complex

Cryo-EM structure of Human Apoferritin at pH 7

Cryo-EM structure of the Cytoplasmic lattice(CPL) from mouse oocyte

Sub-particle structure of the iterative acetyltransferase from Actinomycetes in complex with AcCoA and monoacetylated lasso peptides

Cryo-EM map of a 3-repeat filament from mouse oocyte Cytoplasmic Lattice (CPL)

Cryo EM structure of elk ACE2 in complex with SARS-CoV-2 spike trimer

Cryo EM structure of elk ACE2 in complex with XBB 1.5 spike RBD

C1 local refinement of aquaporin 1 bound to endogenous human stomatin

Human Stomatin - C8 Symmetry

Activated Leptotrichia buccalis (Lbu) CRISPR-Cas13a bound to AI-designed anti-CRISPR AIcrVIA1

C4 local refinement of stomatin-bound aquaporin (human)

C3 local refinement of Urea Transporter B (SLC14A1) bound to human stomatin oligomer

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

Paranemic crossover triangle (PXT) with 2'-Fluoro-modified pyrimidines (FY RNA)

5-Helix Tile - Twist Corrected (5HT-TC) with 2'-Fluoro-modified pyrimidines (FY RNA)

In situ cryo-electron tomogram of rat hippocampal synapse

Single particle cryo electron microscopy of a Fab fragment bound to recombinant human CD40 ligand

Subtomogram average of synaptic microtubule from rat hippocampal neurons

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

In situ cryo-electron tomogram of rat hippocampal synapse

MBP-maltose bound to distal DARPin (AHIR dodecamer scaffold system)

6-Helix Bundle - with a Clasp (6HB-C)-monomer with 2'-Fluoro-modified pyrimidines (FY RNA)

In situ cryo-electron tomogram of rat hippocampal synapse

Control media rat neuronal 80S ribosome state - decoding

Control media rat neuronal 80S ribosome state - peptide bond formation

Control media rat neuronal 80S ribosome - consensus

Nutrient deprived rat neuronal 80S ribosome - consensus

Structure of flagellin FlaB filament in H. pylori

Control media rat neuronal 80S ribosome state - hibernating I

Control media rat neuronal 80S ribosome state - pre-translocating

Flagella filament structure in H. pylori composed of flagellin FlaA

Nutrient deprived rat neuronal 80S ribosome state - decoding

1 h nitrogen + carbon starved yeast-rat-hybrid hibernating disome

Nutrient deprived rat neuronal 80S ribosome state - hibernating IV

Nutrient deprived rat neuronal 80S ribosome state - pre-translocating

Nutrient deprived rat neuronal 80S ribosome state - peptide bond formation

Nutrient deprived rat neuronal 80S ribosome state - hibernating II

Nutrient deprived rat neuronal 110S disome

Nutrient deprived rat neuronal 80S ribosome state - hibernating III

3-4 h cold shock chicken neuronal hibernating tetrasome

Computationally Designed Tetramer of Apo-HC4 (C1 symmetry)

The structure of a Bacterial Cyanide Dihydratase from Bacillus safensis PER-URP-08

The structure of a Fungal Cyanide Hydratase from Gloeocercospora sorghi

SARS-CoV-2 BA.1 S6P (HexaPro) + COV2-3835 Fab Global Map

SARS-CoV-2 BA.1 S6P (HexaPro) + COV2-3835 Fab Local Refinement Map (RBD + Fv)

Structure of Receptor

Human TRPM4 ion channel in MSP2N2 lipid nanodisc in a calcium-bound state

Staphylococcus aureus 70S initiation complex with a natural mRNA

Cryo-EM structure of a tau filament

Structure of the MAP2K MEK1 without bound nucleotide in complex with its substrate MAPK ERK2

Cryo-EM structure of the type VII CRISPR-Cas14 effector complex (Cas7.7/Cas7.8 focused)

Cryo-EM structure of the type VII CRISPR-Cas14 effector complex (Cas14.2/Cas14.4 focused)

Cryo-EM structure of the type VII CRISPR-Cas14 effector complex (Cas5 focused)

Structure of CTF18-PCNA with ATP

Structure of HCMV UL33 in complex with human Gs protein

Cryo-EM structure of Sigma28-RNAP open promoter complex from Pseudomonas aeruginosa

Structural insights into photosystem II supercomplex of a a siphonous green algae Bryopsis corticulans from intertidal zone

Structure of PSI-LHCI-LHCII supercomplex from Bryopsis corticulans

Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome

Cryo-EM Structure of Receptor Tyrosine Kinase ROS1 in Complex with Fab-CT4

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST15

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST10

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST6 and monoclonal fab 045-09 2B05

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST14

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST4

Consensus reconstitution of SLC33A1 in complex with a Fv clasp

Structure of Human SLC33A1 in complex with oxidized glutathione

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST13

Cryo-EM structure of AMPPNP bound human phosphoribosylformylglycinamidine synthase

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST18

Negative stain EM map of H1 HA (A/California/4/2009) in complex with monoclonal fab ST17

Cryo-EM structure of ternary complex of human phosphoribosylglycinamidine synthase with the intermediate (iminophosphate) and ADP bound at the synthase site.

Cryo-EM structure of quaternary complex of human phosphoribosylglycinamidine synthase with thioester intermediate bound (at glutaminase site) and AMPPNP and FGAR (at synthase site).

Bordetella filamentous hemagglutinin (FhaB) C-terminal domain bound to microtubules, ab initio

Bordetella filamentous hemagglutinin (FhaB) C-terminal domain bound to microtubules

Bordetella filamentous hemagglutinin (FhaB) C-terminal domain bound to 14-3 microtubules, aligned

Bordetella filamentous hemagglutinin (FhaB) C-terminal domain bound to 14-3 microtubules

Bordetella filamentous hemagglutinin (FhaB) C-terminal domain bound to microtubules at the seam

CryoEM structure of M. mazei topoisomerase VI(A-E342Q)-minicircle DNA complex in cleavage state

CryoEM structure of M. mazei topoisomerase VI(A-E342Q)-minicircle DNA complex in asymmetric state

Cryo-EM structure of primidone-bound rabbit TRPM3 having 2 resting and 2 activated subunits (ortho position) at 18 degrees Celsius

Human MPC1-2 Complex

CryoEM structure of M. mazei topoisomerase VI-minicircle DNA complex in asymmetric state

CryoEM structure of M. mazei topoisomerase VI-minicircle DNA complex in partially unfolded transducer state

CryoEM structure of M. mazei topoisomerase VI-minicircle DNA complex

Mycoplasma penetrans Methionyl tRNA Synthetase is an Asymmetric Dimer fused to N-terminal Ancillary Domains

Cryo-EM structure of 1:1 chicken ROS1 and chicken NEL complex.

Cryo-EM structure of chicken NEL dimer bound with one human NICOL.

Cryo-EM structure of chicken ROS1 in apo-state. Cryo-EM refinement is focused on the "leg" region of chicken ROS1.

Cryo-EM structure of chicken ROS1 in apo-state. Cryo-EM refinement is focused on the "head" region of chicken ROS1.

Cryo-EM structure of 1:2:1 ROS1/NEL/NICOL holo-complex, conformation 1.

Cryo-EM structure of 1:2:1 ROS1/NEL/NICOL holo-complex, conformation 2.

Andes virus glycoprotein tetramer in complex with ADI-65534 Fab (Global map)

The cryo-EM structure of C. crescentus DriD-ssDNA-RNAP-Sigma73-bapE promoter transcription activation complex

Andes virus glycoprotein tetramer in complex with ADI-65534 Fab (Local map)

Apo form of ClpP1P2 complex from M. tuberculosis

Cryo-EM structure of chicken ROS1 in apo-state. This is the complete map and model.

ClpP1P2 complex from M. tuberculosis bound to Calprotamide A

The cryo-EM structure of C. crescentus DriD-ssDNA-RNAP-Sigma73-didA promoter transcription activation complex

The cryo-EM structure of C. crescentus DriD-ssDNA-RNAP-Sigma73-CCNA_03891/CCNA_01149 promoter transcription activation complex

The cryo-EM structure of C. crescentus RNAP-Sigma73-CCNA_03891/CCNA_01149 promoter complex

Cryo-EM structure of ATPgammaS-bound Vientovirus FB Rep pentamer

Cryo-EM structure of ATPgammaS-bound Vientovirus FB Rep hexamer with endonuclease domain density

Cryo-EM structure of ATPgammaS-bound Vientovirus FB Rep hexamer

Cryo-EM structure of ATPgammaS-bound Vientovirus FB Rep double hexamer with C1 symmetry

Cryo-EM structure of ATPgammaS-bound Vientovirus FB Rep double hexamer with C6 symmetry

Cryo-EM structure of ADP-bound Vientovirus FB Rep hexamer

Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) extended state

Cryo-EM structure of receptor tyrosine kinase ROS1 extracellular domain in complex with NELL2

HIV-1 CA hexamer from purified viral cores, C6 symmetry

Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) docked state

Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) with enantiomer of 17-hydroxyprogesterone caproate

HIV-1 CA hexamer from purified viral cores, C1 symmetry

Cryo-EM structure of receptor tyrosine kinase ROS1 extracellular domain

Cryo-EM map of Mycobacterium tuberculosis pyruvate dehydrogenase complex E2p core subunit DlaT in a hexamer state

Cryo-EM map of Mycobacterium tuberculosis pyruvate dehydrogenase complex E2p core subunit DlaT in a two-hexamer state

Cryo-EM map of Mycobacterium tuberculosis pyruvate dehydrogenase complex E2p core subunit DlaT bound to coenzyme A in a hexamer state

HIV-1 CA hexamer from purified viral cores bound to lenacapavir, C6 symmetry

Cryo-EM map of Corynebacterium glutamicum pyruvate dehydrogenase complex E2p core in a trimer state

Human sterile alpha motif domain-containing protein 9 (SAMD9), monomer

Human sterile alpha motif domain-containing protein 9 (SAMD9), symmetric dimer

Human sterile alpha motif domain-containing protein 9 (SAMD9), loss-of-function mutant R837A

Human sterile alpha motif domain-containing protein 9 (SAMD9), loss-of-function mutant R685Q/G686C/I968C

Human sterile alpha motif domain-containing protein 9 (SAMD9), asymmetric dimer "wing" shape

Human sterile alpha motif domain-containing protein 9 (SAMD9), asymmetric dimer "shell" shape

Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5

Cryo-EM structure of tau filament

Cryo-EM structure of receptor tyrosine kinase ROS1 in complex with NELL2

Structure of amplified aSyn filament by using seed amplification assay (SAA) from MSA patient CSF.

Roseiflexus cells from microbial mat with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Roseiflexus castenholzii cells with contractile injection systems.

Deinococcus aquatilis cells with contractile injection systems.

Roseiflexus cell from microbial mat with contractile injection systems.

Calidithermus chliarophilus cells with contractile injection systems.

Roseiflexus cell from microbial mat with contracted contractile injection systems.

Structure of the Plum Pox Virus (PPV)

Roseiflexus cells from microbial mat with contractile injection systems.

Roseiflexus cells from microbial mat with contracted contractile injection systems.

Roseiflexus cells from microbial mat with contractile injection systems.

Lysed Roseiflexus cells from microbial mat with contracted contractile injection systems.

Roseiflexus cells from microbial mat with contractile injection systems.

Roseiflexus cells from microbial mat with contracted contractile injection systems.

Roseiflexus cells from microbial mat with contractile injection systems.

Roseiflexus cell from microbial mat with contracted contractile injection systems.

Roseiflexus cell from microbial mat with contracted contractile injection systems.

Roseiflexus cells from microbial mat with contractile injection systems.

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5

Cryo-EM structure of Oceanobacillus iheyensis group II intron domains D1-D5