Microtubule-associated LRRK2 I2020T filaments in HEK293T cells treated with GZD-824

Cryo-EM structure of Pyrococcus furiosus RNA polymerase without stalk (no Rpo4/Rpo7)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened consensus map from cryoSPARC non-uniform refinement)

Cryo-EM density of the [NiFe]-hydrogenase HoxEFU diaphorase subcomplex

Focused map of four central LRRK2 I2020T units in the microtubule-associated filament lattice formed in the presence of MLi-2

Focused map of the COR:COR interaction interface in microtubule-associated LRRK2 I2020T filaments formed in the presence of MLi-2

LRRK2 I2020T filaments formed in the presence of MLi-2

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened AHD1 local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened AHD2 local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened CORE1 local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened NBD2 plus T2a local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened CORE2 local refinement map from cryoSPARC)

Alpha-synuclein B

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened WalkerB1 local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened WalkerB2 local refinement map from cryoSPARC)

Alpha-synuclein acetylated lysine 80

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened T2a plus T2a local refinement map from cryoSPARC)

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (sharpened NBD1 plus T2a local refinement map from cryoSPARC)

Alpha-synuclein A

Human respirovirus 3 hemagglutinin-neuraminidase dimer in complex with VHH A2R3-60

Human respirovirus 1 hemagglutinin-neuraminidase dimer in complex with VHH A2R3-60

Human respirovirus 3 hemagglutinin-neuraminidase dimer in complex with VHH A2R3-59

Human muscle nAChR SCCMS eL269F ACh bound

Human muscle nAChR SCCMS eL269F ACh, Reboxetine bound (upper)

Human muscle nAChR FCCMS eP121L ACh-bound

Human muscle nAChR FCCMS eP121L ACh, XG-590 bound

Human muscle nAChR SCCMS eL269F ACh, Reboxetine bound (lower 1)

Human muscle nAChR SCCMS eL269F ACh, Reboxetine bound (lower 2)

Human muscle nAChR SCCMS eT264P ACh bound

Human muscle nAChR SCCMS eL269F ACh, Fluoxetine bound

Human muscle nAChR SCCMS eT264P ACh, Reboxetine bound

Human muscle nAChR SCCMS bV266M ACh bound

Reconstruction focused at FAT-kinase of symmetric class of ATR-ATRIP-ETAA1 AAD

Consensus reconstruction of symmetric class of ATR-ATRIP-ETAA1 AAD

Human muscle nAChR SCCMS bV266M ACh, Quinidine bound

Reconstruction focused at N-heat-M-heat-FAT of symmetric class of ATR-ATRIP-ETAA1 AAD

Reconstruction focused at N-heat-ATRIP of symmetric class of ATR-ATRIP-ETAA1 AAD

Human muscle nAChR SCCMS aV249F ACh, Fluoxetine bound

Reconstruction focused at N-heat-ATRIP of apo-ATR-ATRIP

Consensus reconstruction of apo-ATR-ATRIP

Reconstruction focused at N-heat-ATRIP-M-heat-FAT of open protomer of apo-ATR-ATRIP

Reconstruction focused at N-heat-ATRIP-M-heat-FAT of closed protomer of apo-ATR-ATRIP

Consensus reconstruction of ATR-ATRIP-TOPBP1 AAD

Reconstruction focused at FAT-kinase of apo-ATR-ATRIP

Consensus reconstruction of ATR-ATRIP-TOPBP1 AAD (monomer after symmetry expansion and signal subtraction)

Reconstruction focused at N-heat-ATRIP-M-heat-FAT of ATR-ATRIP-TOPBP1 AAD monomer

Cryo-EM structure of apo-ATR-ATRIP

Cryo-EM structure of ATR-ATRIP-TOPBP1 AAD

Reconstruction focused at FAT-kinase of ATR-ATRIP-TOPBP1 AAD monomer

Cryo-EM structure of ATR-ATRIP-ETAA1 AAD

Cryo-EM structure of symmetric class of ATR-ATRIP-ETAA1 AAD

Sub-tomogram averaged structure of E. Coli DNA protection during starvation protein (DPS)

Reconstruction focused at N-heat-ATRIP of ATR-ATRIP-ETAA1 AAD (S95D/S111D)

Consensus reconstruction of ATR-ATRIP-ETAA1 AAD(S95D/S111D)

Reconstruction focused at N-heat-ATRIP-M-heat of open protomer of ATR-ATRIP-ETAA1 AAD (S95D/S111D)

Reconstruction focused at FAT-kinase of ATR-ATRIP-ETAA1 AAD (S95D/S111D)

Cryo-EM structure of ATR-ATRIP-ETAA1 AAD (S95D/S111D)

Reconstruction focused at N-heat-ATRIP-M-heat-FAT of closed protomer of ATR-ATRIP-ETAA1 AAD (S95D/S111D)

VIPR Ternary Complex with a duplex dsDNA substrate, 6 subunits

Consensus refinement of bmCCAN-DNA dimer

canonical nucleosome in complex with scFv antibodies

Local multi-body refinement of bmCCAN bmCENP-HIK-T dimerization interface, part of the dimeric bmCCAN-DNA complex

Consensus refinement for bmCCAN-DNA complex

bmCENP-HIK Head domain local refinement for apo-bmCCAN

Local multi-body refinement of bmCCAN-2, part of the dimeric bmCCAN-DNA complex

Local multi-body refinement of bmCCAN-1, part of the dimeric bmCCAN-DNA complex

CENP-HIK Head domain local refinement for monomeric bmCCAN-DNA complex

Trypanosoma brucei mitochondrial RNA-editing catalytic complex 2, U-insertion (RECC2), left wing focused refinement map

Trypanosoma brucei mitochondrial RNA-editing catalytic complex 2, U-insertion (RECC2), right wing focused refinement map

Trypanosoma brucei mitochondrial RNA-editing catalytic complex 2, U-insertion (RECC2), consensus map

Trypanosoma brucei mitochondrial RNA-editing catalytic complex (RECC), tRNA focused refinement map

Cryo-EM structure of human VPS34-CI with ADP:MgF3 - local refinement on the complex base

Cryo-EM structure of human VPS34-CI in complex with GABARAP, local refinement on VPS15 helical solenoid, and BECLIN1 and ATG14L N-terminal domains.

Cryo-EM structure of human VPS34-CI with ADP:MgF3 - local refinement on ATG14L and BECLIN1 C-termini

Cryo-EM structure of inhibitor E822-1968 bound human urea transporter A2.

Cryo-EM structure of human VPS34-CI with ADP:MgF3 - local refinement on VPS34 and VPS15 kinases

Cryo-EM structure of human VPS34-CI in complex with GABARAP - alternative conformation, composite map

Cryo-EM structure of human VPS34-CI in complex with GABARAP, local refinement on the core of VPS34-CI.

Cryo-EM structure of human VPS34-CI in complex with GABARAP - alternative conformation, consensus map

Cryo-EM structure of human VPS34-CI in complex with GABARAP - alternative conformation, local refinement on BECLIN1 and ATG14L C-terminal domains.

Cryo-EM structure of human VPS34-CI in complex with GABARAP, consensus map

Cryo-EM structure of human VPS34-CI in complex with GABARAP, local refinement on GABARAP.

Cryo-EM structure of human VPS34-CI in complex with GABARAP, composite map

Cryo-EM structure of human VPS34-CI with ADP:MgF3 - consensus map

Cryo-EM structure of human VPS34-CI in complex with GABARAP, local refinement on BECLIN1 and ATG14L C-terminal domains.

Cryo-EM structure of human VPS34-CI in complex with GABARAP, local refinement on VPS34 and VPS15 kinase domains.

Focus refinement of PEDV HNXX spike monomer with D0 up

PEDV HNXX spike trimer with two D0 down in complex with two N19 Fabs

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Non-catalytic Ub, Left Arm map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Non-catalytic Ub, Right Arm map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Right Arm map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Ub (P2) and Ub (P3) map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Ub (P1') map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Left Arm map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Right Arm map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Consensus Map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Ub (P1') map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Consensus map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Consensus Map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Composite map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Right Arm map)

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Composite map)

Cryo-EM structure of ARISCdC(E33A):K63-Ub4 complex (Ub (P1') map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Composite map)

Vibrio cholerae Glycine Riboswitch - Apo at 3.3A resolution

Cryo-EM structure of human NBCn2 bound to Compound 38J

Cryo-EM structure of human NBCn2 bound to Carbonate

Cryo-EM structure of human NBCn2

Metabotropic Glutamate Receptor 7 in complex with ecto-domain of Extracellular Leucine Rich Repeat and Fibronectin Type III Domain Containing 2

Structure of holo vanadium-dependent haloperoxidase from Enhygromyxa salina bound to vanadate, and bromide

Structure of vanadium-dependent haloperoxidase from Enhygromyxa salina bound to vanadate, bromide, and hydrogen peroxide

Cryo-EM structure of His6-tagged D13 assembled into scaffold-like particles from vaccinia virus

Two interacting D13 trimers at mode III interface in Twister assembly

Cryo-EM structure of A17(1-16) peptide-bound D13 trimer from vaccinia virus

Structure of the heptameric pre-pore state of alpha-hemolysin in the presence of A549 cells at pH 7

Cryo-EM structure of A17(1-16) peptide-bound D13 assembled into scaffold-like particles from vaccinia virus

Structure of the heptameric pore state of alpha-hemolysin in the presence of A549 cells at pH 5.5

Cryo-EM structure of eGFP-tagged D13 assembled into scaffold-like particles from vaccinia virus

Two interacting D13 trimers at mode II interface in Twister assembly

Subtomogram averaging of in vitro assembly product of untagged D13, Twister

Subtomogram averaging of His6-tagged D13 assembled into scaffold-like particles from vaccinia virus

Two interacting D13 trimers at mode I interface in Twister assembly

Cryo-EM structure of in vitro assembly product of untagged D13, Twister

Cryo-EM structure of the A17(1-16) peptide-bound N-terminal 17 residue truncated D13 trimer from vaccinia virus

Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain

Cryo-EM structure of N19 Fab : D0D-S1A

cryoEM structure of influenza B RNP-like particle with NPdel68

Cryo-EM structure of SKM-M.smegmatis 70S ribosomal complex

Optimal tilt-increment for cryo-ET

Cryo-EM structure of the de novo designed metalloprotease PP507 E110Q mutant

Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant

Cryo-EM structure of the de novo designed metalloprotease DP622 E96Q mutant

Human FATP2 K572A mutant in complex with oleic acids and ATP in pre-catalytic state

In-cell map of electron transport chain supercomplex from T cells of older patients after restimulation by subtomogram averaging

In-cell map of mitoribosome from T cells of middle-aged patients after restimulation by subtomogram averaging

In-cell map of electron transport chain supercomplex from T cells of middle-aged patients after restimulation by subtomogram averaging

In-cell map of mitoribosome from T cells of older patients after restimulation by subtomogram averaging

Tomogram of mitochondria in T cell from middle-aged patients after restimulation

Tomogram of mitochondria in T cell from older patients after restimulation

Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Left Arm map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Ub (P2) and Ub (P3) map)

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Left Arm map)

MVV STC intasome in complex with LEDGF

EcMscM lacking the first periplasmic helical bundle and the cytoplasmic extension of TM7 in NaCl in a closed conformation

EcMscM in NaCl in a closed conformation

EcMscM in KCl in an open conformation

Rad55-Rad57-SHU-Rad51-Rad51 bound to ssDNA with AMP-PNP. Local map focused on Rad51

Rad55-Rad57-SHU-Rad51-Rad51 bound to ssDNA with AMP-PNP. Local map focused on SHU

Cryo-EM structure of single-bound FDG antibody VRC49.01 in complex with HIV-1 Env BG505 DS-SOSIP trimer

Cryo-EM structure of Broadly neutralizing antibody VRC48.02 in complex with HIV-1 Env BG505 DS-SOSIP trimer

Rad55-Rad57(E161Q)-SHU-Rad51-Rad51 bound to ssDNA with ATP. Local map focused on Rad55/Rad57

Rad55-Rad57-SHU-Rad51-Rad51 bound to ssDNA with AMP-PNP. Composite map

Core of EcMscM lacking the first periplasmic helical bundle in NaCl in a closed conformation

Rad55-Rad57-SHU-Rad51-Rad51 bound to ssDNA with AMP-PNP. Local map focused on Rad55/Rad57

Cryo-EM structure of triple-bound FDG antibody VRC49.01 in complex with HIV-1 Env BG505 DS-SOSIP trimer

EcMscM in KCl in an open conformation with density for the second periplasmic helical bundle

EcMscM lacking the first periplasmic helical bundle in KCl in an open conformation

Core of EcMscM in NaCl in a closed conformation

EcMscM in KCl in an open conformation, C1 processed

EcMscM lacking the first periplasmic helical bundle in NaCl in a closed conformation

EcMscM in KCl in an open conformation, composite structure

Core of EcMscM lacking the first periplasmic helical bundle and the cytoplasmic extension of TM7 in NaCl in a closed conformation

Cryo-EM structure of double-bound FDG antibody VRC49.01 in complex with HIV-1 Env BG505 DS-SOSIP trimer

Rad55-Rad57(E161Q)-SHU-Rad51-Rad51 bound to ssDNA with ATP. Composite map

Rad55-Rad57(E161Q)-SHU-Rad51-Rad51 bound to ssDNA with ATP. Local map focused on SHU

Rad55-Rad57(E161Q)-SHU-Rad51-Rad51 bound to ssDNA with ATP. Local map focused on Rad51

Rad55-Rad57(E161Q)-SHU-3xRad51 bound to ssDNA with ATP. Local map focused on Rad55/Rad57

Rad55-Rad57(E161Q)-SHU-3xRad51 bound to ssDNA with ATP. Local map focused on SHU

Rad55-Rad57(E161Q)-SHU-3xRad51 bound to ssDNA with ATP. Composite map

Rad55-Rad57(E161Q)-SHU-3xRad51 bound to ssDNA with ATP. Local map focused on Rad51

Rad55-Rad57-SHU homologous recombination complex. Composite map

Structure of adenosine A2AR with an agonist MRS3997

CryoEM structure of EV-D68 strain Fermon procapsid

Structure of adenosine A2BR with an agonist MRS3997

Escherichia coli transcription-translation coupled complex class B (TTC-B) that ribosome walking for 4 codons to a 9 codon mRNA spacer, and fMet-tRNAs in E-site and P-site of the ribosome

CryoEM structure of EV-D68 strain Fermon mature virion

Structure of the PT NTD-C1536-CoV2-3434-BLN8 complex

Structure of the PT NTD-C1554-C1540 complex

Human TIM22 complex wtih substrate GGC1-sfGFP

Human TOM complex with substrate Tim22-GGC1-sfGFP

cryo-EM structure of a mammalian collagen fibril

Human TOM-TIM22 supercomplex with substrate GGC1-sfGFP

Human TOM complex with substrate GGC1-sfGFP

PEDV HNXX spike trimer with two D0 down

PEDV HNXX spike trimer with one D0 down

PEDV HNXX spike trimer with one D0 Down in complex with one N19 Fab

Focus refinement of PEDV HNXX spike monomer with D0 down in complex with N19 Fab

SARS-CoV-2 BA.3.2.2(RE.2.2) RBD in complex with monoclonal antibodies S2K146 and L4.65

PEDV HNXX S trimer with three D0 down

Cryo-EM map of the S1 inner region for the vitreous body collagen fibril at 3.69 angstrom

SARS-CoV-2 BA.3.2.2(RE.2.2) spike protein

Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Zoniporide in an outward-open conformation

Cryo-EM map of the S4 inner region for the vitreous body collagen fibril at 3.24 angstrom

Cryo-EM map of the S3 outer region for the vitreous body collagen fibril at 3.83 angstrom

Cryo-EM map of the S2 outer region for the vitreous body collagen fibril at 5.34 angstrom

Cryo-EM map of the opticin region for the vitreous body collagen fibril at 3.46 angstrom

Cryo-EM map of the S1 outer region for the vitreous body collagen fibril at 5.02 angstrom

Cryo-EM map of the S4 outer region for the vitreous body collagen fibril at 5.37 angstrom

Cryo-EM map of the S2 inner region for the vitreous body collagen fibril at 3.18 angstrom

Cryo-EM map of the S3 inner region for the vitreous body collagen fibril at 3.23 angstrom

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus full-length L protein RdRP elongation complex (EC14b form)

cryo-EM structure of acetyl-CoA carboxyltransferase holoenzyme dimer from Shewanella oneidensis, mutant E1238A

Cryo-EM map of the vitreous body collagen fibril at 4.7 angstrom

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus L protein (apo form)

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus full-length L protein RdRP elongation complex (EC14 form)

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus L protein (5'-cRNA-bound form)

D0-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP

Fusion protein of Helicoverpa armigera nucleopolyhedrovirus in the prefusion state

Fusion protein of Helicoverpa armigera nucleopolyhedrovirus in an early fusion intermediate state

Fusion protein of Helicoverpa armigera nucleopolyhedrovirus in the postfusion state

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator SNH-119014

Cryo-EM structure of inhibitor M353-0039 bound urea transporter A2.

Subtomogram averaging of spike-P17-IgG solo structure on fixed SARS-CoV-2

Subtomogram averaging of SARS-CoV-2 spike-P17-IgG Gemini structure

Subtomogram averaging of SARS-CoV-2 spike-S309-IgG solo structure in 1-RBD-up conformation

Subtomogram averaging of SARS-CoV-2 spike-S309-IgG Gemini structure

Subtomogram averaging of SARS-CoV-2 spike-P17-IgG solo structure

Subtomogram averaging of SARS-CoV-2 spike-S309-IgG solo structure in closed conformation

Structure of RAG transposon end complex (TEC)

Structure of transposase-activated RAG target capture complex with symmetric linear target DNA (TCC-LS)

Cryo-EM structure of the fiber region of Parabacteroide phage PD491P1

Structure of transposase-activated RAG (RAG1 E962N) target capture complex with disordered U-shaped target DNA (TCC-UD)

Structure of transposase-activated RAG target capture complex with X-form U-shaped target DNA (TCC-UDX)

Structure of transposase-activated RAG strand transfer complex in state 1 (STC-1)

Structure of transposase-activated RAG strand transfer complex in state 2 (STC-2)

AMP-PNP bound E.coli CnoX-GroEL complex, state I without symmetry

AMP-PNP bound E.coli CnoX-GroEL complex, state I

Cryo-electron microscopy structure of nanofibers formed by azobenzene peptides.

SARS-CoV-2 ancestral spike S-2P

AMP-PNP bound E.coli CnoX-GroEL complex, state II

AMP-PNP bound E.coli CnoX-GroEL/ES complex, state III

AMP-PNP bound E.coli CnoX-GroEL/ES complex, state IV

Type IV-A1 CasDinG loaded state, focused map

Type IV-A1 CRISPR effector complex bound to dsDNA and CasDinG - loaded state

Composite cryo-EM density map of TRI-611:ALK:CRBN:DDB1

Type IV-A1 CRISPR effector complex in loaded state, consensus map

Type IV-A1 CRISPR effector complex bound to dsDNA and CasDinG - locked state

Cryo-EM structure of L9-L4 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)

Cryo-EM structure of ALK in complex with CRBN/DDB1 and TRI-611

Type IV-A1 CRISPR effector complex in locked state, consensus map

Cryo-EM structure of L9-F4 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)

Type IV-A1 CasDinG locked state, focused map

Alpha-synuclein acetylated lysine 80 A

NorA in outward-open conformation bound to inhibitor IMP2380

Human FANCJ helicase bound to a fork DNA in the closed state

Cryo-EM structure of human VPS34-CI with ADP:MgF3 - composite map

Alpha-synuclein acetylated lysine 80 B

Human FANCJ helicase bound to a fork DNA in the open state

Reconstruction focused at N-heat-ATRIP of ATR-ATRIP-TOPBP1 AAD monomer

Cryo-EM structure of the complete Saccharomyces cerevisiae RNA polymerase II in closed clamp conformation

Cryo-EM structure of the complete Saccharomyces cerevisiae RNA polymerase II in open clamp conformation

Cryo-EM structure of the complete Pyrococcus furiosus RNA polymerase in open clamp conformation

Cryo-EM structure of the complete Pyrococcus furiosus RNA polymerase in closed clamp conformation

Cryo-EM structure of the complete Sulfolobus acidocaldarius RNA polymerase in closed clamp conformation

Cryo-EM structure of the complete Sulfolobus acidocaldarius RNA polymerase in open clamp conformation

CryoEM structure of Shaker ILT (V369I,I372L,S376T)

Cryo-EM structure of Saccharomyces cerevisiae RNA polymerase II without stalk (no Rpb4/Rpb7)

Cryo-EM structure of Sulfolobus acidocaldarius RNA polymerase without stalk (no Rpo4/Rpo7)

Monomeric ADAR2_E488Q bound to dsRNA sequence derived from human GLI1 gene