EMD-66225

Helical reconstruction
1.98 Å
EMD-66225
3D View Gallery
Deposition: 17/09/2025
Map released: 05/08/2026
Last modified: 05/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66225

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9wtw summary report (pdf.gz) Map-9wtw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain

EMD-66225

Helical reconstruction
1.98 Å
EMD-66225
3D View Gallery
Deposition: 17/09/2025
Map released: 05/08/2026
Last modified: 05/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Amyloid-beta 40 (A21G) Flemish filaments extracted from human brain with Alzheimer's disease
Fitted models: 9wtw

Deposition Authors: Guillen-Poza PA, Yang Y, Hervas R
Distinct amyloid-beta filament fold in individuals with APP Flemish mutation
Khaki PSS, Guillen-Poza PA, Wong C, Robinson AC, Ng RC-L, Yang Y, Hervas R
(2026) Nat Struct Mol Biol
DOI: doi:10.1038/s41594-026-01855-y
ISSN: 1545-9985
Grant Support: