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Structure of a human ABCE1-bound 43S pre-initiation complex - State II

Electron Microscopy
3.8Å resolution
PDB entry 6zvj coloured by chain, front view.
PDB entry 6zvj coloured by chain, side view.
PDB entry 6zvj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 51-mer (preferred)
Entry contents: 49 distinct polypeptide molecules
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 51-mer
Accessible surface area: 630126.61 Å2
Buried surface area: 257259.22 Å2
Dissociation area: 1,978.96 Å2
Dissociation energy (ΔGdiss): -4.65 kcal/mol
Dissociation entropy (TΔSdiss): 25.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-104449

Macromolecules

Small ribosomal subunit protein uS2
Chain: a
Length: 216 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08865 (Residues: 2-217; Coverage: 73%)
Gene names: LAMBR, LAMR1, RPSA
Pfam: Ribosomal protein S2
InterPro:
Small ribosomal subunit protein uS2 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS2 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS2 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS1
Chain: p
Length: 211 amino acids
Theoretical weight: 24.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61247 (Residues: 23-233; Coverage: 80%)
Gene names: FTE1, MFTL, RPS3A
Pfam: Ribosomal S3Ae family
InterPro:
Small ribosomal subunit protein eS1 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS1 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS1 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein uS5
Chain: d
Length: 216 amino acids
Theoretical weight: 23.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P15880 (Residues: 60-275; Coverage: 74%)
Gene names: RPS2, RPS4
Pfam:
InterPro:
Small ribosomal subunit protein uS5 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS5 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS5 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS26
Chain: Q
Length: 101 amino acids
Theoretical weight: 11.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62854 (Residues: 2-102; Coverage: 88%)
Gene name: RPS26
Pfam: Ribosomal protein S26e
InterPro:
Small ribosomal subunit protein eS26 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS26 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS26 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS4, X isoform
Chain: q
Length: 255 amino acids
Theoretical weight: 28.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62701 (Residues: 2-256; Coverage: 97%)
Gene names: CCG2, RPS4, RPS4X, SCAR
Pfam:
InterPro:
Small ribosomal subunit protein eS4, X isoform in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS4, X isoform in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS4, X isoform in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS32
Chain: W
Length: 24 amino acids
Theoretical weight: 3.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62945 (Residues: 1-24; Coverage: 96%)
Gene name: RPL41
Pfam: Ribosomal protein L41
InterPro: Large ribosomal subunit protein eS32
Small ribosomal subunit protein eS32 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS32 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS32 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS6
Chain: r
Length: 222 amino acids
Theoretical weight: 25.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62753 (Residues: 2-223; Coverage: 89%)
Gene names: OK/SW-cl.2, RPS6
Pfam: Ribosomal protein S6e
InterPro:
Small ribosomal subunit protein eS6 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS6 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS6 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS7
Chain: s
Length: 181 amino acids
Theoretical weight: 20.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62081 (Residues: 13-193; Coverage: 93%)
Gene name: RPS7
Pfam: Ribosomal protein S7e
InterPro:
Small ribosomal subunit protein eS7 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS7 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS7 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS8
Chain: t
Length: 205 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62241 (Residues: 2-206; Coverage: 99%)
Gene names: OK/SW-cl.83, RPS8
Pfam: Ribosomal protein S8e
InterPro:
Small ribosomal subunit protein eS8 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS8 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS8 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS4
Chain: c
Length: 180 amino acids
Theoretical weight: 21.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46781 (Residues: 2-181; Coverage: 93%)
Gene name: RPS9
Pfam:
InterPro:
Small ribosomal subunit protein uS4 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS4 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS4 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein uS17
Chain: n
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62280 (Residues: 4-147; Coverage: 91%)
Gene name: RPS11
Pfam:
InterPro:
Small ribosomal subunit protein uS17 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS17 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS17 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein uS15
Chain: m
Length: 149 amino acids
Theoretical weight: 17.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62277 (Residues: 2-150; Coverage: 99%)
Gene name: RPS13
Pfam:
InterPro:
Small ribosomal subunit protein uS15 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS15 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS15 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein uS11
Chain: i
Length: 125 amino acids
Theoretical weight: 13.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: A0A2R8Y811 (Residues: 26-150; Coverage: 83%)
Gene name: RPS14
Pfam: Ribosomal protein S11
InterPro:
Small ribosomal subunit protein uS11 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS11 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS11 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein eS21
Chain: y
Length: 82 amino acids
Theoretical weight: 8.98 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63220 (Residues: 1-82; Coverage: 99%)
Gene name: RPS21
Pfam: Ribosomal protein S21e
InterPro:
Small ribosomal subunit protein eS21 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS21 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS21 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS8
Chain: f
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62244 (Residues: 2-130; Coverage: 99%)
Gene names: OK/SW-cl.82, RPS15A
Pfam: Ribosomal protein S8
InterPro:
Small ribosomal subunit protein uS8 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS8 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS8 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS12
Chain: j
Length: 139 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62266 (Residues: 2-140; Coverage: 97%)
Gene name: RPS23
Pfam: Ribosomal protein S12/S23
InterPro:
Small ribosomal subunit protein uS12 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS12 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS12 in PDB entry 6zvj, assembly 1, top view.
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40S ribosomal protein S24
Chain: z
Length: 122 amino acids
Theoretical weight: 14.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: E7ETK0 (Residues: 5-126; Coverage: 93%)
Gene name: RPS24
Pfam: Ribosomal protein S24e
InterPro:
40S ribosomal protein S24 in PDB entry 6zvj, assembly 1, front view.
40S ribosomal protein S24 in PDB entry 6zvj, assembly 1, side view.
40S ribosomal protein S24 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS27
Chain: R
Length: 82 amino acids
Theoretical weight: 9.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42677 (Residues: 2-83; Coverage: 98%)
Gene names: MPS1, RPS27
Pfam: Ribosomal protein S27
InterPro:
Small ribosomal subunit protein eS27 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS27 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS27 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS30
Chain: T
Length: 44 amino acids
Theoretical weight: 5.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62861 (Residues: 81-124; Coverage: 33%)
Gene name: FAU
Pfam: Ribosomal protein S30
InterPro: Small ribosomal subunit protein eS30
Small ribosomal subunit protein eS30 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS30 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS30 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS17
Chain: w
Length: 130 amino acids
Theoretical weight: 15.04 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08708 (Residues: 2-131; Coverage: 96%)
Gene names: RPS17, RPS17L
Pfam: Ribosomal S17
InterPro:
Small ribosomal subunit protein eS17 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS17 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS17 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS9
Chain: g
Length: 138 amino acids
Theoretical weight: 15.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62249 (Residues: 9-146; Coverage: 95%)
Gene name: RPS16
Pfam: Ribosomal protein S9/S16
InterPro:
Small ribosomal subunit protein uS9 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS9 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS9 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS3
Chain: b
Length: 224 amino acids
Theoretical weight: 24.87 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P23396 (Residues: 4-227; Coverage: 92%)
Gene names: OK/SW-cl.26, RPS3
Pfam:
InterPro:
Small ribosomal subunit protein uS3 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS3 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS3 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS7
Chain: e
Length: 189 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46782 (Residues: 16-204; Coverage: 93%)
Gene name: RPS5
Pfam: Ribosomal protein S7p/S5e
InterPro:
Small ribosomal subunit protein uS7 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS7 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS7 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS10
Chain: u
Length: 95 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46783 (Residues: 1-95; Coverage: 58%)
Gene name: RPS10
Pfam: Plectin/S10 domain
InterPro:
Small ribosomal subunit protein eS10 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS10 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS10 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS12
Chain: v
Length: 116 amino acids
Theoretical weight: 12.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25398 (Residues: 14-129; Coverage: 88%)
Gene name: RPS12
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
InterPro:
Small ribosomal subunit protein eS12 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS12 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS12 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS19
Chain: o
Length: 119 amino acids
Theoretical weight: 14.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62841 (Residues: 15-133; Coverage: 82%)
Gene names: RIG, RPS15
Pfam: Ribosomal protein S19
InterPro:
Small ribosomal subunit protein uS19 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS19 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS19 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS13
Chain: k
Length: 140 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62269 (Residues: 3-142; Coverage: 92%)
Gene names: D6S218E, RPS18
Pfam: Ribosomal protein S13/S18
InterPro:
Small ribosomal subunit protein uS13 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS13 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS13 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS19
Chain: x
Length: 141 amino acids
Theoretical weight: 15.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39019 (Residues: 2-142; Coverage: 97%)
Gene name: RPS19
Pfam: Ribosomal protein S19e
InterPro:
Small ribosomal subunit protein eS19 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS19 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS19 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS10
Chain: h
Length: 98 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60866 (Residues: 19-116; Coverage: 82%)
Gene name: RPS20
Pfam: Ribosomal protein S10p/S20e
InterPro:
Small ribosomal subunit protein uS10 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS10 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS10 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS25
Chain: P
Length: 70 amino acids
Theoretical weight: 7.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62851 (Residues: 44-113; Coverage: 56%)
Gene name: RPS25
Pfam: S25 ribosomal protein
InterPro:
Small ribosomal subunit protein eS25 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS25 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS25 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS28
Chain: S
Length: 61 amino acids
Theoretical weight: 6.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62857 (Residues: 8-68; Coverage: 88%)
Gene name: RPS28
Pfam: Ribosomal protein S28e
InterPro:
Small ribosomal subunit protein eS28 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS28 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS28 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein uS14
Chain: l
Length: 54 amino acids
Theoretical weight: 6.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62273 (Residues: 2-55; Coverage: 96%)
Gene name: RPS29
Pfam: Ribosomal protein S14p/S29e
InterPro:
Small ribosomal subunit protein uS14 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein uS14 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein uS14 in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Small ribosomal subunit protein eS31
Chain: U
Length: 62 amino acids
Theoretical weight: 7.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62979 (Residues: 88-149; Coverage: 40%)
Gene names: RPS27A, UBA80, UBCEP1
Pfam: Ribosomal protein S27a
InterPro:
Small ribosomal subunit protein eS31 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein eS31 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein eS31 in PDB entry 6zvj, assembly 1, top view.
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Small ribosomal subunit protein RACK1
Chain: V
Length: 309 amino acids
Theoretical weight: 34.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63244 (Residues: 4-312; Coverage: 98%)
Gene names: GNB2L1, HLC7, PIG21, RACK1
Pfam: WD domain, G-beta repeat
InterPro:
Small ribosomal subunit protein RACK1 in PDB entry 6zvj, assembly 1, front view.
Small ribosomal subunit protein RACK1 in PDB entry 6zvj, assembly 1, side view.
Small ribosomal subunit protein RACK1 in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit I
Chain: I
Length: 316 amino acids
Theoretical weight: 35.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13347 (Residues: 1-316; Coverage: 97%)
Gene names: EIF3I, EIF3S2, TRIP1
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit I in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit I in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit I in PDB entry 6zvj, assembly 1, top view.
Molecule details ›

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Eukaryotic translation initiation factor 3 subunit B
Chain: B
Length: 566 amino acids
Theoretical weight: 65.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55884 (Residues: 180-745; Coverage: 70%)
Gene names: EIF3B, EIF3S9
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit B in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit B in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit B in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit A
Chain: A
Length: 722 amino acids
Theoretical weight: 85.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14152 (Residues: 4-725; Coverage: 52%)
Gene names: EIF3A, EIF3S10, KIAA0139
Pfam: PCI domain
InterPro:
Eukaryotic translation initiation factor 3 subunit A in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit A in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit A in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit C
Chain: C
Length: 743 amino acids
Theoretical weight: 86.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: B4DVU3 (Residues: 1-129, 130-761; Coverage: 98%)
Gene names: EIF3C, EIF3S8
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit C in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit C in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit C in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit E
Chain: E
Length: 429 amino acids
Theoretical weight: 50.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60228 (Residues: 2-430; Coverage: 96%)
Gene names: EIF3E, EIF3S6, INT6
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit E in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit E in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit E in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit F
Chain: F
Length: 269 amino acids
Theoretical weight: 29.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00303 (Residues: 89-357; Coverage: 75%)
Gene names: EIF3F, EIF3S5
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit F in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit F in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit F in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit H
Chain: H
Length: 318 amino acids
Theoretical weight: 36.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15372 (Residues: 35-352; Coverage: 90%)
Gene names: EIF3H, EIF3S3
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit H in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit H in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit H in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit K
Chain: K
Length: 217 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UBQ5 (Residues: 2-218; Coverage: 100%)
Gene names: ARG134, EIF3K, EIF3S12, HSPC029, MSTP001, PTD001
Pfam: CSN8/PSMD8/EIF3K family
InterPro:
Eukaryotic translation initiation factor 3 subunit K in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit K in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit K in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit L
Chain: L
Length: 372 amino acids
Theoretical weight: 44.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y262 (Residues: 181-552; Coverage: 66%)
Gene names: EIF3EIP, EIF3L, EIF3S6IP, HSPC021, HSPC025, MSTP005
Pfam: RNA polymerase I-associated factor PAF67
InterPro:
Eukaryotic translation initiation factor 3 subunit L in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit L in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit L in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit M
Chain: M
Length: 362 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7L2H7 (Residues: 11-372; Coverage: 97%)
Gene names: EIF3M, GA17, HFLB5, PCID1, PNAS-125
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit M in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit M in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit M in PDB entry 6zvj, assembly 1, top view.
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ATP-binding cassette sub-family E member 1
Chain: 1
Length: 595 amino acids
Theoretical weight: 66.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61221 (Residues: 4-598; Coverage: 99%)
Gene names: ABCE1, OK/SW-cl.40, RLI, RNASEL1, RNASELI, RNS4I
Pfam:
InterPro:
ATP-binding cassette sub-family E member 1 in PDB entry 6zvj, assembly 1, front view.
ATP-binding cassette sub-family E member 1 in PDB entry 6zvj, assembly 1, side view.
ATP-binding cassette sub-family E member 1 in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 1
Chain: N
Length: 91 amino acids
Theoretical weight: 10.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P41567 (Residues: 23-113; Coverage: 81%)
Gene names: EIF1, SUI1
Pfam: Translation initiation factor SUI1
InterPro:
Eukaryotic translation initiation factor 1 in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 1 in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 1 in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit D
Chain: D
Length: 527 amino acids
Theoretical weight: 61.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15371 (Residues: 1-527; Coverage: 96%)
Gene names: EIF3D, EIF3S7
Pfam: Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
InterPro: Eukaryotic translation initiation factor 3 subunit D
Eukaryotic translation initiation factor 3 subunit D in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit D in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit D in PDB entry 6zvj, assembly 1, top view.
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RNA recognition motif (unknown)
Chain: Y
Length: 78 amino acids
Theoretical weight: 5.56 KDa
Source organism: Homo sapiens
InterPro: Antifreeze protein, type I
RNA recognition motif (unknown) in PDB entry 6zvj, assembly 1, front view.
RNA recognition motif (unknown) in PDB entry 6zvj, assembly 1, side view.
RNA recognition motif (unknown) in PDB entry 6zvj, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit J
Chains: G, J
Length: 258 amino acids
Theoretical weight: 29.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75822 (Residues: 1-258; Coverage: 100%)
Gene names: EIF3J, EIF3S1, PRO0391
Pfam: Translation initiation factor eIF3 subunit
InterPro:
Eukaryotic translation initiation factor 3 subunit J in PDB entry 6zvj, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit J in PDB entry 6zvj, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit J in PDB entry 6zvj, assembly 1, top view.
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RNA chain 2
Name: 18S Ribosomal RNA
Representative chains: 2
Length: 1720 nucleotides
Theoretical weight: 555.21 KDa
Rfam: Eukaryotic small subunit ribosomal RNA
18S Ribosomal RNA in PDB entry 6zvj, assembly 1, front view.
18S Ribosomal RNA in PDB entry 6zvj, assembly 1, side view.
18S Ribosomal RNA in PDB entry 6zvj, assembly 1, top view.
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