Family

Eukaryotic translation initiation factor 3 subunit H (IPR027524)

Short name: eIF3h

Family relationships

None.

Description

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [PMID: 17403899, PMID: 21940399]. It is a non-peptidase homologue in peptidase family M67 (MEROPS identifier M67.971).

Results suggest that eIF3h regulates cell growth and viability, and that over-expression of the gene may provide growth advantage to prostate, breast, and liver cancer cells [PMID: 11733359, PMID: 14578863, PMID: 16652384].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER
HAMAP