Domain

SUI1 domain (IPR001950)

Short name: SUI1

Domain relationships

None.

Description

In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [PMID: 1729602]. SUI1 is a protein of 108 residues. Close homologues of SUI1 have been found [PMID: 7904817] in mammals, insects and plants. SUI1 is also evolutionary related to:

  • Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
  • Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).

Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:

  • Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
  • Ligatin (gene: LGTN). This protein is found in mammals and insects.

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam