Homologous Superfamily

K homology domain superfamily, prokaryotic type (IPR009019)

Short name: KH_sf_prok-type

Overlapping entries


The K homology domain is a common RNA-binding motif present in one or multiple copies in both prokaryotic and eukaryotic regulatory proteins. The KH motifs may act cooperatively to bind RNA in the case of multiple motifs, or independently in the case of single KH motif proteins. Prokaryotic (pKH) and eukaryotic (eKH) KH domains share a KH-motif, but have different topologies. The pKH domain has been found in a number of proteins, including the N-terminal domain of the S3 ribosomal protein [PMID: 11014182], the C-terminal domain of Era GTPase [PMID: 10411886] and the two C-terminal domains of the NusA transcription factor [PMID: 11430821]. The structure of the pKH domain consists of a two-layer alpha/beta fold in the arrangement alpha/beta(2)/alpha/beta.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.