Domain

Rpn11/EIF3F, C-terminal (IPR024969)

Short name: Rpn11/EIF3F_C

Domain relationships

None.

Description

This domain is found at the C terminus of many regulatory proteins, including the yeast proteasomal subunit Rpn11 and eukaryotic initiation factor 3 subunit F (eIF3f). The Rpn11 C-terminal domain is necessary for normal mitochondrial morphology and function and is thought to regulate the mitochondrial fission and tubulation processes [PMID: 18172023]. The eIF3f C-terminal domain is critical for proper eIF3f activity in skeletal muscle through its interaction with mTOR (also known as FRAP, RAFT1 or RAPT) [PMID: 19073596, PMID: 20126553].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam