Family

Eukaryotic translation initiation factor 3 subunit C (IPR027516)

Short name: EIF3C

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Eukaryotic translation initiation factor 3 subunit C (EIF3C) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. EIF3C appears to be important for eIF3 activity [PMID: 17581632]. Its N-terminal domain mediates eIF3 binding to eIF1 and eIF5 [PMID: 22718758], and its C-terminal PCI domain forms an important intermolecular bridge between eIF3 and the 40S ribosome [PMID: 22123745].

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0031369 translation initiation factor binding

Cellular Component

GO:0005852 eukaryotic translation initiation factor 3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP