Domain

RNase L inhibitor RLI, possible metal-binding domain (IPR007209)

Short name: RNaseL-inhib_metal-bd_dom

Domain relationships

None.

Description

This is a possible metal-binding domain in endoribonuclease RNase L inhibitor. It is found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, fer4, IPR001450. Also often found adjacent to IPR007177 in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [PMID: 9524254], and could possibly play a more general role in the regulation of RNA stability in mammalian cells. Inhibitory activity requires concentration-dependent association of RLI with RNase L [PMID: 7539425].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam