Eukaryotic translation initiation factor 3 subunit E, N-terminal (IPR019010)

Short name: eIF3e_N

Overlapping homologous superfamilies


Domain relationships



This entry represents the N-terminal domain of the eukaryotic translation initiation factor 3 subunit E. EIF3 is required in protein synthesis in mammalian cells and, together with other initiation factors, stimulates binding of initiator methionyl-tRNAi and mRNA to the 40S ribosomal subunit to form the 48 S initiation complex [PMID: 17322308]. The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection. EIF3 has at least 13 protein components (eIF3a-m or 1-13), where subunits h, i, k, and m are likely to be on the periphery of the complex [PMID: 17322308]. Subunit 6 is produced by the int6 gene, one of the frequent integration sites for mouse mammary tumor viruses [PMID: 18502752].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.