Eukaryotic translation initiation factor SUI1 (IPR005874)

Short name: SUI1_euk

Overlapping homologous superfamilies

Family relationships



eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown [PMID: 9488467].

Cells have evolved elaborate mechanisms to rid themselves of aberrant proteins and transcripts. The nonsense-mediated mRNA decay pathway (NMD) is an example of a pathway that eliminates aberrant mRNAs. In addition to its role in recognition of the AUG codon during translation initiation and maintenance of the appropriate reading frame during translation elongation by directing the ribosome to the proper start site of translation by functioning in concert with eIF-2 and the initiator tRNA-Met, the SUI1 protein plays a role in the NMD pathway [PMID: 10376878].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.