Homologous Superfamily

Translation initiation factor 3, subunit 12, N-terminal, eukaryotic (IPR016020)

Short name: Transl_init_fac_sub12_N_euk

Overlapping entries


This superfamily represents the N-terminal domain found in several eukaryotic translation initiation factor 3 subunit 12 (eIF-3 p25; also known as subunit K) proteins. Eukaryotic initiation factor 3 (eIF3) is a multi-subunit complex that is required for binding of mRNA to 40S ribosomal subunits, stabilisation of ternary complex binding to 40S subunits, and dissociation of 40S and 60S subunits [PMID: 11042177].

GO terms

Biological Process

GO:0006446 regulation of translational initiation

Molecular Function

GO:0043022 ribosome binding
GO:0003743 translation initiation factor activity

Cellular Component

GO:0005852 eukaryotic translation initiation factor 3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.