Domain

K homology domain-like, alpha/beta (IPR015946)

Short name: KH_dom-like_a/b

Domain relationships

Description

The K homology domain is a common RNA-binding motif present in one or multiple copies in both prokaryotic and eukaryotic regulatory proteins. The KH motifs may act cooperatively to bind RNA in the case of multiple motifs, or independently in the case of single KH motif proteins. Prokaryotic (pKH) and eukaryotic (eKH) KH domains share a KH-motif, but have different topologies. The pKH domain has been found in a number of proteins, including the N-terminal domain of the S3 ribosomal protein [PMID: 11014182], the C-terminal domain of Era GTPase [PMID: 10411886] and the two C-terminal domains of the NusA transcription factor [PMID: 11430821]. The structure of the pKH domain consists of a two-layer alpha/beta fold in the arrangement alpha/beta(2)/alpha/beta.

This entry represents prokaryotic-type K homology domains, as well as related domains that share the same 2-layer alpha/beta structure.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D