Homologous Superfamily

Eukaryotic translation initiation factor 3-like domain superfamily (IPR023194)

Short name: eIF3-like_dom_sf

Overlapping entries


At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA binding[PMID: 1742346]. eIF-3 is the most complex translation inititation factor, consisting of about 13 putative subunits and having a molecular weight of between 550 - 700 kDa in mammalian cells. Subunits are designated eIF-3a - eIF-3m; the large number of subunits means that the interactions between the individual subunits that make up the eIF-3 complex are complex and varied.

This superfamily represents an alpha helical domain found in eIF-3 subunit J proteins. The eIF-3j subunit can bind to the 40S ribosome alone and its binding site overlaps that of the eIF-3 complex [PMID: 16829125].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.