Eukaryotic translation initiation factor 3 subunit C, N-terminal domain (IPR008905)

Short name: EIF3C_N_dom

Overlapping homologous superfamilies


Domain relationships



The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [PMID: 8995409]. The N-terminal domain of eukaryotic translation initiation factor 3 subunit C mediates eIF3 binding to eIF1 and eIF5 [PMID: 22718758].

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003743 translation initiation factor activity
GO:0031369 translation initiation factor binding

Cellular Component

GO:0005852 eukaryotic translation initiation factor 3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.