Homologous Superfamily

Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721)

Short name: Ribosomal_S5_D2-typ_fold_subgr

Overlapping entries



Domain 2 of the ribosomal protein S5 has a left-handed beta-alpha-beta fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this beta-alpha-beta fold domain include:

  • Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [PMID: 8722013].
  • Ribonuclease P protein (RNase P) [PMID: 17081993].
  • DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) [PMID: 11574484].
  • GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (EC:, homoserine kinase (EC:, and mevalonate kinase (EC: [PMID: 15544330, PMID: 11188689].
  • Caenorhabditis elegans early switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) [PMID: 12672694].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.