Structure of human KCNQ1-CaM complex

Cryo-EM structure of SspE from E.coli

Cryo-EM structure of SspE-R133A from E.coli

Cryo-EM structure of Anabaena tRNA(Leu) precursor at Pre-2S state

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

Polyclonal immune complex comprising B41 SOSIP.v4.1 in complex with polyclonal antibodies from rabbit r1645 - Obtained by negative stain EM.

Polyclonal immune complex comprising AMC009 SOSIP.v4.2 in complex with polyclonal antibodies from rabbit UA0065 - Obtained by negative stain EM.

Polyclonal immune complex comprising CH505(B) SOSIP.v8.1 in complex with polyclonal antibodies from rabbit r2476 - Obtained by negative stain EM.

Polyclonal immune complex comprising AMC009 SOSIP.v4.2 in complex with polyclonal antibodies from rabbit UA0063 - Obtained by negative stain EM.

Cryo-EM structure of Arabidopsis TIR-NLR WRR4A tetramer in complex with effector CCG40 (C2-symmetry)

Polyclonal immune complex comprising AMC009 SOSIP.v4.2 in complex with polyclonal antibodies from rabbit UA0066 - Obtained by negative stain EM.

Polyclonal immune complex comprising CH505(B) SOSIP.v8.1 in complex with polyclonal antibodies from rabbit r2473 - Obtained by negative stain EM.

Polyclonal immune complex comprising AMC009 SOSIP.v4.2 in complex with polyclonal antibodies from rabbit UA0062 - Obtained by negative stain EM.

Polyclonal immune complex comprising AMC009 SOSIP.v4.2 in complex with polyclonal antibodies from rabbit UA0064 - Obtained by negative stain EM.

Polyclonal immune complex comprising CH505(B) SOSIP.v8.1 in complex with polyclonal antibodies from rabbit r2477 - Obtained by negative stain EM.

Polyclonal immune complex comprising B41 SOSIP.v4.1 in complex with polyclonal antibodies from rabbit r1644 - Obtained by negative stain EM.

Polyclonal immune complex comprising B41 SOSIP.v4.1 in complex with polyclonal antibodies from rabbit r1648 - Obtained by negative stain EM.

Polyclonal immune complex comprising CH505(B) SOSIP.v8.1 in complex with polyclonal antibodies from rabbit r2475 - Obtained by negative stain EM.

Cryo-EM structure of H. neapolitanus CsoSCA in oxidizing conditions, dimer, major state, active conformation

Cryo-EM structure of H. neapolitanus CsoSCA in oxidizing conditions, hexamer

Cryo-EM structure of H. neapolitanus CsoSCA in oxidizing conditions, dimer, minor state

Human thioredoxin reductase 1 (SeCys 498 Cys) with Cu(I)

Cryo-EM structure of H. neapolitanus CsoSCA C283A/C284A inactive mutant, dimer, state 2

Cryo-EM structure of H. neapolitanus CsoSCA C283A/C284A inactive mutant, hexamer

Cryo-EM structure of H. neapolitanus CsoSCA in reducing conditions, hexamer

human Ribonuclease MRP state 1

large lobe of human Ribonuclease MRP

Cryo-EM structure of the ClpE/ClpP degradation complex from E.faecalis

Cryo-EM structure of H. neapolitanus CsoSCA in reducing conditions, dimer, minor state

human Ribonuclease MRP state 2

Cryo-EM structure of H. neapolitanus CsoSCA C283A/C284A inactive mutant, dimer, state 1

Cryo-EM structure of H. neapolitanus CsoSCA in reducing conditions, dimer, major state, inactive conformation

Cryo-EM structure of semi-closed state of Botulinum neurotoxin serotype A at pH 7.4

Cryo-EM reconstruction of the cyanophage Pam5 small terminase

CryoEM structure of Human LonP1-TFAM complex

Structure of the type IV pilus machinery from Thermus thermophilus in the open state (C6 symmetry)

Structure of the type IV pilus machinery from Thermus thermophilus in the closed state (C13 symmetry)

Structure of the type IV pilus machinery from Thermus thermophilus in the open state (C13 symmetry)

Cryo-EM structure of GGCX-BGP complex

Cryo-EM structure of Human Mre11-Nbs1 complex

transporter

transporter

transporter complex

Human OXGR1-miniGq complex (conformation 1)

transporter

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

CryoEM structure of EcKatG S-Trp105 at 2.22 Angstrom resolution revealing an asymmetric sulfur center in O=S-Trp

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibodies 4D08 and 1C08

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 1C08

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 1G01

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 1G03

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 4D04

Negative Stain Electron Microscopy map of the Measles Virus Hemagglutinin Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 1C02

Complex structure of human p97 bound to Faf1 and Ufd1 (NTD focused)

Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (NPL4 focused)

LDLRAD3-vLA1-VLDLR-LA2 in complex with VEEV TC-83 VLPs (ASU)

LDLRAD3-vLA1-VLDLR-LA2 in complex with EEEV PE-6 VLPs (ASU)

Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (motor focused)

Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (State1)

Cryo-EM structure of substrate engaged p97-Ufd1-Npl4-Faf1 complex in initiating conformation 1

Cryo-EM structure of substrate engaged p97-Ufd1-Npl4-Faf1 complex in initiating conformation 2

Structure of TMEM106B doublet from patient brain derived lysosomes

Structure of TMEM106B singlet from patient brain derived lysosomes

cryoEM map for soluble OmpA beta-barrel WRAPs

cryoEM map of OmpA helical WRAP

S. marcescens Cas10-Csm unbound to target RNA

CryoEM map of CK52.1 in complex with Q23.V033GT

CK52.1 Fab in complex with Q23.RH-GT. Env

Q23.MD39 in Complex with Fabs from antibodies CH01 and 35O22

KIF1A R350G bound to microtubules in the apo state

Cryo-EM structure of DRT2-RT-ncRNA binary complex

Structure of the CCL21-CCR7-Gi-scFv16 complex

KIF1A R350G bound to microtubules in two-heads-bound state with AMP-PNP

KIF1A R350W bound to microtubules in the apo state

Structure of the CCL19-CCR7-Gi-scFv16 complex

Structure of hTRPC3 solubilized with 4F peptide at 2.72 angstrom

KIF1A R350W bound to microtubules in two-heads-bound state with AMP-PNP

E.coli cytochrome bd-I dimer in the apo and MK bound closed state

D14.F25.S02 Fab complexed to DENV2-US/BID/V594/2006 virus-3f-2f Fab map

E.coli cytochrome bd-I monomer

E.coli cytochrome bd-I dimer in the MK bound open and closed state

E.coli cytochrome bd-I dimer bound to Aurachin D

Gephyrin E domain dimer R379D variant

E. coli cytochrome bd-I monomer

E. coli cytochrome bd-I monomer

E. coli cytochrome bd-I dimer bound to menaquinone

D14.F25.S02 IgG complexed to DENV2-US/BID/V594/2006 virus

D14.F25.S02 Fab complexed to DENV2-US/BID/V594/2006 virus (5f-3f map)

Cryo-EM structure of DDB1-CRBN in complex with dHuR-2 and HuR

Gephyrin E domain dimer G375D variant

Gephyrin E domain dimer D422N variant

Polar sheathed flagella with reduced flagellins in Vibrio alginolyticus

Large cell body of Nerearchaeum marumarumayae

Nerearchaeum marumarumayae interaction with gram negative bacterium

Extended cell phenotype of Nerearchaeum marumarumayae

sensory rhodopsin I with its cognate transducer HtrI

Tomogram of HER2 containing extracellular vesicles from SKBR3 cells

Tomogram of HER2 containing membrane vesicles mechanically induced from SKBR3 cells

cryo-EM structure of GLP-1R-Gs complex with glucagon

Cryo-EM structure of type VII CRISPR-Cas complex at the target engagement state

Cryo-EM structure of GCGR-Gs complex with peptide 15

Beta1-tryptase monomer bound to inhibitory Fabs E82.AS and E104.v2

Cryo-EM structure of GLP-1R-Gs complex with oxyntomodulin

Cryo-EM structure of GCGR-Gs complex with oxyntomodulin

Recombinant AD PHF complexed with SW-MK-NBD (Non Symmetric Binding Site)

Recombinant AD THF with SW-MK-NBD complexed in AD-related Binding Site

cryo-EM structure of GLP-1R-Gs complex with SRB103H

Recombinant AD THF incubated with DMSO (Kinked Backbone E342)

Recombinant AD PHF complexed with SW-MK-NBD

Negative Stain Electron Microscopy map of the Measles Virus Fusion Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 2B11

Recombinant AD THF incubated with DMSO (Flat Backbone E342)

Cryo-EM structure of GLP-1R-Gs complex with SRB103Q

Wildtype rabbit TRPV5 in nanodics in the presence of Menthol and PI(4,5)P2

Recombinant AD PHF incubated with DMSO (Kinked Backbone E342)

Recombinant AD THF incubated with SW-MK-NBD (Non-Symmetric Binding)

Recombinant AD THF complexed with SW-MK-NBD (Secondary Binding Site)

cryo-EM structure of GCGR-Gs complex with SRB103H

cryo-EM structure of GCGR-Gs complex with SRB103Q

Negative Stain Electron Microscopy map of the Measles Virus Fusion Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 2D07

Recombinant AD PHF complexed with SW-MK-NBD (PHF2)

Negative Stain Electron Microscopy map of the Measles Virus Fusion Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 3A12

Negative Stain Electron Microscopy map of the Measles Virus Fusion Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 4F09

Disulfide-trapped SMO-L637C/PKA-C complex

SMO/PKA-C complex in MSP1E3D1 nanodiscs

SMO/PKA-C complex, dual EDC/Sulfo-NHS and BS3 crosslinking

SMO/PKA-C complex, mixed prior to grid preparation

EDC/Sulfo-NHS-crosslinked SMO/PKA-C complex

BS3-crosslinked Smoothened/PKA-C complex

Negative Stain Electron Microscopy map of the Measles Virus Fusion Glycoprotein Ectodomain in Complex with the Neutralizing Antibody 2G05

Cryo-EM structure of an extracellular contractile injection system in Salmonella enterica subspecies salamae, the sheath in contracted state.

Cryo-EM structure of a contractile injection system in Salmonella enterica subspecies Salamae, the cap portion in extended state.

CryoEM structure of a membrane protein associated with a contractile injection in Salmonella enterica subspecies salamae

Cryo-EM structure of an extracellular contractile injection system in Salmonella enterica subspecies salamae, the sheath and inner tube module in extended state.

Cryo-EM structure of a contractile injection system in Salmonella enterica subspecies Salamae, the baseplate portion in extended state.

Cryo-EM structure of human ZAC in zinc Binding State

Focused map of AGO2 MID/PIWI domain from Hsp90-p23-AGO2-miRNA duplex

Cryo-EM structure of human ZAC in complex with d-tubocurarine

Consensus map of Hsp90-p23-AGO2

Subtomogram average of Apoferrtin (11x11) using CRYO ARM 300II

AGO2-focused map of Hsp90-p23-AGO2

Cryo-EM structure of human ZAC in nanodisc in apo state

Focused map of Hsp90-p23 and lumen from Hsp90-p23-AGO2-miRNA duplex

Consensus map of Hsp90-p23-AGO2-miRNA duplex

Cryo-EM structure of human ZAC with A152 mutant in zinc binding state

Focused map of AGO2 N-domain from Hsp90-p23-AGO2-miRNA duplex

Cryo-EM structure of human ZAC in complex with N-(4-(tert-butyl)thiazol-2-yl)-3-fluorobenzamide (TTFB)

AGO maturation complex (AMC): AGO2-miRNA duplex in complex with Hsp90 beta and co-chaperone p23

Local map of Ggust region of Ggust-coupled TAS2R43 with aristolochic acid I

Local map of Gi region for Gi-coupled TAS2R43 with aristolochic acid I

Cryo-EM structure of GCGR-Gs complex with glucagon

Consensus map for Gi-coupled TAS2R43 with aristolochic acid I

Local map of GPCR region of Gi-coupled TAS2R43 with aristolochic acid I

Cryo-EM structure of GLP-1R-Gs complex with peptide 15

Local map of GPCR region of Ggust-coupled TAS2R43 with aristolochic acid I

Consensus map of Ggust-coupled TAS2R43 with aristolochic acid I

CryoEM structure of Gi-coupled TAS2R43 with aristolochic acid I

CryoEM structure of Ggust-coupled TAS2R43 with aristolochic acid I

Cryo-EM Structure of Ab568 Fab in complex with SARS-CoV-2 6P Spike

cryo-EM structure of a catalytic inactive mutant(D391A) of DPE1 dimer

cryo-EM structure of maltose and glucose bound rice PHS1(R709A)-DPE1(D391A) complex

Empty 50S Subunit of the Coxiella burnetii Ribosome

cryo-EM structure of a catalytic inactive mutant(R709A) of PHS1 dimer

cryo-EM structure of maltose and glucose bound rice PHS1(R709A)-DPE1(D391A) complex

Cryo-EM structure of rice PHS1-DPE1 complex

Doxycycline Bound E. coli Ribosome with Rearranged Peptidyl Transferase Centre

HPFcold Bound Hibernating C. burnetii 30S Ribosome

70S Coxiella burnetii Ribosome with Doxycycline and HPFcold

Doxycycline Bound C. burnetii 30S Ribosome

Triple Stack Doxycycline Bound 50S Subunit of the Coxiella burnetii Ribosome

Cryo-EM structure of rice PHS1-DPE1 complex

30S Doxycycline Bound E. coli Ribosome

Ribosome subtomogram average

Structure of the human DCAF2-DDB1 complex

CryoEM structure of the T2R46 in complex with Denatomium benozate and heterotrimeric G protein complex

CryoEM structure of T2R14 in complex with chlorhexidine and heterotrimeric G protein complex

Cryo-EM structure of apo-T2R46 in complex with heterotrimeric G protein

CryoEM structure of the T2R46 in complex with tangeretin and heterotrimeric G protein complex

Cryo-EM structure of T2R14 in complex with tangeretin and heterotrimeric G protein

CryoEM structure of T2R46 in complex with Arteminisin and heterotrimeric G protein complex

CryoEM structure of the T2R46 in complex with strychine and heterotrimeric G protein complex

Cryo-EM structure of human ZAC in zinc partially binding state in nanodisc

cryo-EM structure of AKT phosphorylated mTOR complex 2, overall refinement

cryo-EM structure of dephosphorylated mTOR complex 2, focused on a single protomer

cryo-EM structure of autophosphorylated mTOR complex 2, overall refinement

cryo-EM structure of autophosphorylated mTOR complex 2, focused on a single protomer

cryo-EM structure of AKT phosphorylated mTOR complex 2, focused on a single protomer

cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane

cryo-EM structure of dephosphorylated mTOR complex 2, overall refinement

Structure of beta-1,3-glucan synthase from Saccharomyces cerevisiae (ScFks1) at the catalytically relevant ground state

Structure of beta-1,3-glucan synthase from Saccharomyces cerevisiae (ScFks1) at the catalytically less relevant L1 state

Structure of beta-1,3-glucan synthase in complex with caspofungin, Rho1 and long glucan

Structure of beta-1,3-glucan synthase from Saccharomyces cerevisiae (ScFks1) in complex with short glucan

Structure of beta-1,3-glucan synthase from Saccharomyces cerevisiae (ScFks1) at the catalytically less relevant L2 state

Beta-1,3-glucan synthase Fks1 S643P from Saccharomyces Cerevisiae

Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1 top)

Structure of CXCR4 in complex with a de-novo designed mini-protein antagonist

Cryo-EM structure of SARS-CoV-2 XBB.1.5 S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1)

Cryo-EM structure of SARS-CoV-2 XBB.1.5 S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1 top)

Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab

Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1)

Cryo-EM structure of SARS-CoV-2 XBB.1.5 S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab

Clr4(delKMT) Binding to H3K14 Ubiquitinated Nucleosome

Full-length Clr4 Binding to H3K14 Ubiquitinated Nucleosome

Cryo-EM structure of human alpha5beta1 integrin bound to NeoNectin from Biortus

Complex of FMDV O/18074 and porcine-derived neutralizing monoclonal antibody pO18-10

SthK intermediate state at low temperature, cAMP-bound in the presence of DOPE

SthK closed state at low temperature, cAMP-bound in the presence of DOPE

Cryo-tomogram of COPI and COPII vesicles and buds from FIB-milled RPE-1 cells.

CryoEM structure of GFP-like protein from Aequorea coerulescens with Trimbody

Local refinement of RNA-free assembled Langya virus N-core

Cryo-EM structure of HQY1027-bound alpha-synuclein fibril polymorph 6A6B

CryoEM structure of IgV domain of human Nectin-4 with Trimbody

CryoEM structure of human Galectin-10 with iTrimbody

Structure of yeast 1,3-beta-glucan synthase FKS2

CryoEM structure of IgV domain of human Nectin-4 with Trimbody

CryoEM structure of human Galectin-10 with iTrimbody

Langya henipavirus Ncore 13mer Ring

Cryo-EM structure of circular intron of Anabaena tRNA(Leu) precursor

Cryo-EM structure of linear intron of Anabaena tRNA(Leu) precursor

CryoEM structure of human Galectin-10 with iTrimbody

Cryo-EM structure of Anabaena tRNA(Leu) precursor at Apo state

Cryo-EM structure of Anabaena tRNA(Leu) precursor at Pre-1S state

Complex of GTP cyclohydrolase with GTP

CryoEM structure of GFP-like protein from Aequorea coerulescens with Trimbody

Helical reconstruction of Langya henipavirus N-core nucleocapsid-like complex