EMD-65166

Single-particle
4.14 Å
EMD-65166 Deposition: 26/06/2025
Map released: 22/04/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65166

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9vls summary report (pdf.gz) Map-9vls FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of SARS-CoV-2 XBB.1.5 S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1)

EMD-65166

Single-particle
4.14 Å
EMD-65166 Deposition: 26/06/2025
Map released: 22/04/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Sample: the local S2-76E1 map of the XBB.1.5 E-FIC-76E1 structure
Fitted models: 9vls

Deposition Authors: Liu ZM, Bao ZH, Sun XY, Sun L
Steric hindrance of antibody binding in an Omicron spike fusion intermediate.
Bao Z, Liu Z, Zhang Z, Wang X, Jin X , Bai J, Ma H, Li Y, Yi C, Ling Z , Huang Z , Zhang L , Chen Z , Xie Y , Wang Y , Sun L , Sun X
(2026) Nature , 654 , 762 - 770
PUBMED: 42092153
DOI: doi:10.1038/s41586-026-10462-2
ISSN: 1476-4687
ASTM: NATUAS