EMD-48419

Single-particle
3.0 Å
EMD-48419
3D View Gallery
Deposition: 20/12/2024
Map released: 22/04/2026
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48419

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mnb summary report (pdf.gz) Map-9mnb FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Beta1-tryptase monomer bound to inhibitory Fabs E82.AS and E104.v2

EMD-48419

Single-particle
3.0 Å
EMD-48419
3D View Gallery
Deposition: 20/12/2024
Map released: 22/04/2026
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Human beta1-tryptase bound to inhibitory Fabs E82.AS and E104.v2
Fitted models: 9mnb

Deposition Authors: Azumaya CM , Maun HR , Rohou AL
Complete inhibition of beta-tryptase by tetramer dissociation and active site allostery due to a single antibody residue.
Maun HR , Azumaya CM , Walters BT , Vij R, Morando A , Loyet KM , Koerber JT , Rohou A , Lazarus RA
(2026) Nat Commun , 17
PUBMED: 41957026
DOI: doi:10.1038/s41467-026-70491-3
ISSN: 2041-1723
Grant Support: