EMD-75038
Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961
EMD-75038
Single-particle2.9 Å
Deposition: 09/01/2026Map released: 22/04/2026
Last modified: 06/05/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of HBS1L, cereblon, and DDB1 with TNG961
Fitted models: 10ay
Deposition Authors: Whittington DA
Sample: Ternary complex of HBS1L, cereblon, and DDB1 with TNG961
Fitted models: 10ay
Deposition Authors: Whittington DA
TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of FOCAD-deleted cancers.
Nicholson HE ,
Whittington DA ,
Bruzzese FJ ,
Lazarides K ,
Martires LCM ,
Tonini MR ,
Jenkins HN ,
Zhang M ,
Shahagadkar P ,
Pratt CB ,
Briggs KJ ,
McCarren P ,
Tsai A ,
Bandi M ,
Min C ,
Huang A ,
Zhang H ,
Meier SR ,
Shen B ,
Yu Y ,
Liang C ,
Liu Y ,
Teng T ,
Zhang J ,
Crystal A ,
Mallender WD ,
Wu XE ,
Maxwell JP ,
Andersen JN
(2026) Cancer Discov
,
Whittington DA ,
Bruzzese FJ ,
Lazarides K ,
Martires LCM ,
Tonini MR ,
Jenkins HN ,
Zhang M ,
Shahagadkar P ,
Pratt CB ,
Briggs KJ ,
McCarren P ,
Tsai A ,
Bandi M ,
Min C ,
Huang A ,
Zhang H ,
Meier SR ,
Shen B ,
Yu Y ,
Liang C ,
Liu Y ,
Teng T ,
Zhang J ,
Crystal A ,
Mallender WD ,
Wu XE ,
Maxwell JP ,
Andersen JN
(2026) Cancer Discov
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