EMD-75038

Single-particle
2.9 Å
EMD-75038
3D View Gallery
Deposition: 09/01/2026
Map released: 22/04/2026
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75038
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 10ay summary report (pdf.gz) Map and 10ay FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

EMD-75038

Single-particle
2.9 Å
EMD-75038
3D View Gallery
Deposition: 09/01/2026
Map released: 22/04/2026
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of HBS1L, cereblon, and DDB1 with TNG961
Fitted models: 10ay

Deposition Authors: Whittington DA

TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of FOCAD-deleted cancers
Nicholson HE, Whittington DA, Bruzzese FJ, Lazarides K, Martires LCM, Tonini MR, Jenkins HN, Zhang M, Shahagadkar P, Pratt CB, Briggs KJ, McCarren P, Tsai A, Bandi M, Min C, Huang A, Zhang H, Meier SR, Shen B, Yu Y, Liang C, Liu Y, Teng T, Zhang J, Crystal AS, Mallender WD, Wu X, Maxwell JP, Andersen JN
(2026) Cancer Discov
ISSN: 2159-8290
Grant Support: