EMD-65569

Single-particle
3.4 Å
EMD-65569
3D View Gallery
Deposition: 27/07/2025
Map released: 22/04/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65569

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9w2f summary report (pdf.gz) Map-9w2f FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of DDB1-CRBN in complex with dHuR-2 and HuR

EMD-65569

Single-particle
3.4 Å
EMD-65569
3D View Gallery
Deposition: 27/07/2025
Map released: 22/04/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of HuR-CRBN/DDB1 with dHuR-2
Fitted models: 9w2f

Deposition Authors: Dou H, Zhu Y
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer.
Lu X, Wang X, Yang Z, Wang X, Wang L, Xu C, Lo IC, Geng C, Wang L, Pu Y, Zhang K, Zhu Z, Ye L, Huang J, Wei X, Bai F, Zhu Y, Qian X, Dou H, Su H, Cang Y
(2026) Nature , 655 , 780 - 789
PUBMED: 42271059
DOI: doi:10.1038/s41586-026-10613-5
ISSN: 1476-4687
ASTM: NATUAS