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Substrates for peptidase S01.300: kallikrein-related peptidase 7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
72 kDa type IV collagenase {ECO:0000303|PubMed:2162831, ECO:0000303|PubMed:2834383} P08253 30-660 peptide-Phe80+Phe-peptide P MS Met Gln Lys Phe Phe Gly Leu Pro Silva et al., 2019
cadherin-6 P55285 54-790 peptide-Tyr343+Thr-peptide P MS Lys Lys Val Tyr Thr Leu Lys Val Silva et al., 2019
calsyntenin-1 O94985 29-981 peptide-Tyr169+Lys-peptide P MS Glu Lys Ser Tyr Lys Ala Thr Val Silva et al., 2019
Caspase-14 P31944 1-242 Peptide-Tyr178+Arg-Peptide P MS Tyr Ile Ala Tyr Arg His Asp Gln Yamamoto et al., 2012
cathelicidin antimicrobial peptide P49913 134-170 peptide-Phe138+Phe-peptide P Leu Gly Asp Phe Phe Arg Lys Ser Yamasaki et al., 2006 22750
cathelicidin antimicrobial peptide P49913 134-170 peptide-Phe139+Arg-peptide P Gly Asp Phe Phe Arg Lys Ser Lys Yamasaki et al., 2006 22751
cathelicidin antimicrobial peptide P49913 134-170 peptide-Phe150+Lys-peptide P Gly Lys Glu Phe Lys Arg Ile Val Yamasaki et al., 2006 22752
cathelicidin antimicrobial peptide P49913 134-170 peptide-Phe160+Leu-peptide P Ile Lys Asp Phe Leu Arg Asn Leu Yamasaki et al., 2006 22753
collagen alpha-1(VII) chain Q02388 17-2944 peptide-Tyr2819+Ala-peptide P MS Leu Pro Ser Tyr Ala Ala Asp Thr Silva et al., 2019
collagen alpha-1(XII) chain Q99715 24-3063 peptide-Asp1139+Asn-peptide P MS Gly Pro Tyr Asp Asn Thr Val Val Silva et al., 2019
collagen alpha-1(XII) chain Q99715 24-3063 peptide-Tyr1138+Asp-peptide P MS Val Gly Pro Tyr Asp Asn Thr Val Silva et al., 2019
collagen alpha-1(XII) chain Q99715 24-3063 peptide-Met2926+Leu-peptide P MS Phe Asn Gln Met Leu Asn Gln Ile Silva et al., 2019
dickkopf-related protein 3 Q9UBP4 22-350 peptide-Phe128+Ser-peptide P MS Gln Met Val Phe Ser Glu Thr Val Silva et al., 2019
ezrin P15311 1-586 peptide-Tyr424+Thr-peptide P MS Leu Ala Glu Tyr Thr Ala Lys Ile Silva et al., 2019
fibrillin-1 {ECO:0000303|PubMed:15221638} P35555 45-2731 peptide-Tyr1760+Thr-peptide P MS Ile Asp Ile Tyr Thr Gly Leu Pro Silva et al., 2019
follistatin-related protein 3 O95633 27-263 peptide-Leu84+Gly-peptide P MS Ile Asn Leu Leu Gly Phe Leu Gly Silva et al., 2019
galectin-3-binding protein Q08380 19-585 peptide-Tyr442+Ser-peptide P MS Leu Val Lys Tyr Ser Ser Asp Tyr Silva et al., 2019
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu+Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Asn Gln His Leu Cya Gly Ser His Debela et al., 2006 21047
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Debela et al., 2006 21049
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Egelrud, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala N Gly Phe Phe Tyr Thr Pro Lys Ala Egelrud, 2004
insulin-like growth factor-binding protein 3 P17936 28-291 peptide-Tyr186+Lys-peptide P MS Ser Gln Arg Tyr Lys Val Asp Tyr Silva et al., 2019
insulin-like growth factor-binding protein 6 P24592 28-240 peptide-Arg165+His-peptide P MS Pro Cys Arg Arg His Leu Asp Ser Silva et al., 2019
insulin-like growth factor-binding protein 6 P24592 28-240 peptide-Tyr179+Arg-peptide P MS Thr Glu Val Tyr Arg Gly Ala Gln Silva et al., 2019
interstitial collagenase P03956 20-469 peptide-Phe70+Phe-peptide P MS Met Gln Glu Phe Phe Gly Leu Lys Silva et al., 2019
interstitial collagenase P03956 20-469 peptide-Phe71+Gly-peptide P MS Gln Glu Phe Phe Gly Leu Lys Val Silva et al., 2019
interstitial collagenase P03956 20-469 peptide-Tyr116+Arg-peptide P MS His Leu Thr Tyr Arg Ile Glu Asn Silva et al., 2019
interstitial collagenase P03956 20-469 peptide-Phe242+Ser-peptide P MS Ser Tyr Thr Phe Ser Gly Asp Val Silva et al., 2019
Kallikrein-1 precursor P06870 19-262 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-2 precursor P20151 19-261 peptide-Arg24+Ile-peptide P NT Ile Gln Ser Arg Ile Val Gly Gly Yoon et al., 2007
Kallikrein-9 precursor Q9UKQ9 16-250 peptide-Arg22+Ala-peptide P NT Ala Asp Thr Arg Ala Ile Gly Ala Yoon et al., 2007
MeOSuc-Arg-Pro-Tyr-NHPhNO2 MeOSuc-Arg-Pro-Tyr+NHPhNO2 S MSu Arg Pro Tyr NAN - - - Egelrud, 2004
nidogen-2 Q14112 31-1375 peptide-Asn80+Gly-peptide P MS Val Gly Thr Asn Gly Ile Ile Ser Silva et al., 2019
nidogen-2 Q14112 31-1375 peptide-Tyr124+Arg-peptide P MS Arg Val Leu Tyr Arg Glu Asp Thr Silva et al., 2019
prosaposin P07602 17-524 peptide-Phe171+Met-peptide P MS Val Ala Pro Phe Met Ala Asn Ile Silva et al., 2019
Prostate-specific antigen precursor P07288 18-261 peptide-Arg24+Ile-peptide P NT Ile Leu Ser Arg Ile Val Gly Gly Yoon et al., 2007
SPARC P09486 18-303 peptide-Tyr179+Glu-peptide P MS Val Thr Leu Tyr Glu Arg Asp Glu Silva et al., 2019
stromelysin-2 P09238 18-476 peptide-Phe99+Ser-peptide P MS Val Gly His Phe Ser Ser Phe Pro Silva et al., 2019
Suc-Ala-Ala-Pro-Phe-NHPhNO2 Suc-Ala-Ala-Pro-Phe+NHPhNO2 S Ala Ala Pro Phe NAN - - - Debela et al., 2006
thrombospondin-1 P07996 19-1170 peptide-Tyr258+Ile-peptide P MS Arg Thr Asn Tyr Ile Gly His Lys Silva et al., 2019
thrombospondin-1 P07996 19-1170 peptide-Tyr665+Leu-peptide P MS Lys Cys Asn Tyr Leu Gly His Tyr Silva et al., 2019
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Debela et al., 2006
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Debela et al., 2006

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