Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P09486

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	unknown peptidase	1-303	P	release of a signal peptide	NT	Fisher et al., 1987
20	cathepsin K	18-303	P		NT	Bossard et al., 1996
37	matrix metallopeptidase-2	18-303	P	normal turnover		Sasaki et al., 1997
37	matrix metallopeptidase-3	18-303	P	normal turnover		Sasaki et al., 1997
37	matrix metallopeptidase-7	18-303	P	normal turnover		Sasaki et al., 1997
47	matrix metallopeptidase-2	18-303	P	normal turnover		Sasaki et al., 1997
47	matrix metallopeptidase-9	18-303	P	normal turnover		Sasaki et al., 1997
47	matrix metallopeptidase-13	18-303	P	normal turnover		Sasaki et al., 1997
49	matrix metallopeptidase-9	18-303	P	normal turnover		Sasaki et al., 1997
49	matrix metallopeptidase-13	18-303	P	normal turnover		Sasaki et al., 1997
54	matrix metallopeptidase-7	18-303	P	normal turnover		Sasaki et al., 1997
104	matrix metallopeptidase-3	71-303	P			Sage et al., 2003
150	trypsin 1	18-303	N		MS	Schilling & Overall, 2008
166	matrix metallopeptidase-3	71-303	P			Sage et al., 2003
166	trypsin 1	18-303	N		MS	Schilling & Overall, 2008
195	cathepsin K	18-303	P		NT	Bossard et al., 1996
214	matrix metallopeptidase-2	18-303	P	normal turnover		Sasaki et al., 1997
214	matrix metallopeptidase-9	18-303	P	normal turnover		Sasaki et al., 1997
214	matrix metallopeptidase-3	18-303	P	normal turnover		Sasaki et al., 1997
214	matrix metallopeptidase-7	18-303	P	normal turnover		Sasaki et al., 1997
214	matrix metallopeptidase-13	18-303	P	normal turnover		Sasaki et al., 1997
254	matrix metallopeptidase-2	18-303	P	normal turnover		Sasaki et al., 1997
254	matrix metallopeptidase-3	71-303	P			Sage et al., 2003
254	matrix metallopeptidase-7	18-303	P	normal turnover		Sasaki et al., 1997
254	matrix metallopeptidase-13	18-303	P	normal turnover		Sasaki et al., 1997