Structure for peptidase S01.300: kallikrein-related peptidase 7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
2QXI_A Homo sapiens 1.00 Å high resolution structure of human kallikrein 7 in complex with suc-ala-ala-pro-phe-chloromethylketone
Catalytic residues are shown in ball-and-stick representation: His70 in purple, Asp102 in pink and Ser205 in orange. The bound inhibitor suc-ala-ala-pro-phe-chloromethylketone is shown in grey ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
complex with Ala-Ala-Phe-chloromethylketone 2.60 Å 2QXG 2QXG 2QXG 2QXG 2QXG 2QXG Debela et al., 2007
complex with Suc-Ala-Ala-Pro-Phe-chloromethylketone 2.00 Å 2QXH 2QXH 2QXH 2QXH 2QXH 2QXH Debela et al., 2007
high resolution structure of human kallikrein 7 in complex with suc-ala-ala-pro-phe-chloromethylketone 1.00 Å 2QXI 2QXI 2QXI 2QXI 2QXI 2QXI Debela et al., 2007
complex with Suc-Ala-Ala-Pro-Phe-chloromethylketone and copper 2.10 Å 2QXJ 2QXJ 2QXJ 2QXJ 2QXJ 2QXJ Debela et al., 2007
produced as a secretion protein in E. coli 2.80 Å 3BSQ 3BSQ 3BSQ 3BSQ 3BSQ 3BSQ Fernandez et al., 2008
kallikrein-7 in complex with compound1 1.10 Å 5FAH 5FAH 5FAH 5FAH 5FAH 5FAH
human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one 2.15 Å 5Y9L 5Y9L 5Y9L 5Y9L 5Y9L 5Y9L
human kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative 2.40 Å 5YJK 5YJK 5YJK 5YJK 5YJK 5YJK
Mus musculus
mouse kallikrein 7 1.93 Å 5ZFH 5ZFH 5ZFH 5ZFH 5ZFH 5ZFH
mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative 1.80 Å 5ZFI 5ZFI 5ZFI 5ZFI 5ZFI 5ZFI
mouse kallikrein 7 in complex with imidazolinylindole derivative 1.75 Å 6AHS 6AHS 6AHS 6AHS 6AHS 6AHS