Literature for peptidase S01.300: kallikrein-related peptidase 7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G. Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing J Pathol (2026) PubMed Europe PubMed DOI

2024

Boumali,R., Urli,L., Naim,M., Soualmia,F., Kinugawa,K., Petropoulos,I. and El Amri,C. Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey Biochimie (2024) 226, 77-90. PubMed Europe PubMed DOI

2023

Xu,J., Ye,W., Yang,T.T., Yan,T., Cai,H., Zhou,A. and Yang,Y. DNA accelerates the protease inhibition of a bacterial serpin chloropin Front Mol Biosci (2023) 10, 1157186-1157186. PubMed Europe PubMed DOI PMC EPMC

2022

Gonschorek,P., Zorzi,A., Maric,T., Le Jeune,M., Schuttel,M., Montagnon,M., Gomez-Ojea,R., Vollmar,D.P., Whitfield,C., Reymond,L., Carle,V., Verma,H., Schilling,O., Hovnanian,A. and Heinis,C. Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin J Med Chem (2022) 65, 9735-9749. PubMed Europe PubMed DOI
Xiang,F., Wang,Y., Cao,C., Li,Q., Deng,H., Zheng,J., Liu,X. and Tan,X. The Role of Kallikrein 7 in Tumorigenesis Curr Med Chem (2022) 29, 2617-2631. PubMed Europe PubMed DOI V
Yin,N., Pan,F., Qiu,L., Yang,Z., Xiong,R., Shi,L., Shi,Y., Wu,N., Wu,K., Li,Q., Wen,D., Huang,Q., Zhang,Y., Mi,Y. and Ji,Q. Vaspin Alleviates Sepsis-Induced Cardiac Injury and Cardiac Inflammation by Inhibiting Kallikrein 7 in Mice Mediators Inflamm (2022) 2022, 1149582-1149582. PubMed Europe PubMed DOI PMC EPMC

2021

Bisyris,E., Zingkou,E., Kordopati,G.G., Matsoukas,M., Magriotis,P.A., Pampalakis,G. and Sotiropoulou,G. A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases Chem Commun (Camb) (2021) 57, 6507-6510. PubMed Europe PubMed DOI
Kunath,A., Weiner,J., Krause,K., Rehders,M., Pejkovska,A., Gericke,M., Biniossek,M.L., Dommel,S., Kern,M., Ribas-Latre,A., Schilling,O., Brix,K., Stumvoll,M., Kloting,N., Heiker,J.T. and Bluher,M. Role of Kallikrein 7 in Body Weight and Fat Mass Regulation Biomedicines (2021) 9 PubMed Europe PubMed DOI PMC EPMC
Yeo,H., Ahn,S.S., Lee,J.Y. and Shin,S.Y. EGR-1 acts as a transcriptional activator of KLK7 under IL-13 stimulation Biochem Biophys Res Commun (2021) 534, 303-309. PubMed Europe PubMed DOI K
Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L. Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases Front Med (Lausanne) (2021) 8, 777619-777619. PubMed Europe PubMed DOI PMC EPMC V

2020

Guo,C.J., Mack,M.R., Oetjen,L.K., Trier,A.M., Council,M.L., Pavel,A.B., Guttman-Yassky,E., Kim,B.S. and Liu,Q. Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation J Invest Dermatol (2020) 140, 1244-1252. PubMed Europe PubMed DOI
Hanke,S., Tindall,C., Pippel,J., Ulbricht,D., Pirotte,B., Reboud-Ravaux,M., Heiker,J.T. and Strater,N. Structural studies on the inhibitory binding mode of aromatic coumarinic esters to human kallikrein-related peptidase 7 J Med Chem (2020) PubMed Europe PubMed DOI I
Kumar,D.V., Sivaranjani,Y. and Rao,G.V. Immunohistochemical expression of kallikrein 7 in oral squamous cell carcinoma J Oral Maxillofac Pathol (2020) 24, 580-580. PubMed Europe PubMed DOI PMC EPMC
Lim,S.C., Kee,K.H., Lee,M.J., Hong,R. and Han,S.I. Extracellular acidity induced expression of kallikrein related peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells Oncol Rep (2020) 43, 1705-1713. PubMed Europe PubMed DOI

2019

Dan,L. and Yonggang,L. Molecular characteristics and association analysis with litter size trait for porcine KLK7 gene Anim Biotechnol (2019) , 1-5. PubMed Europe PubMed DOI
Li,M., Srp,J., Gustchina,A., Dauter,Z., Mares,M. and Wlodawer,A. Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes Acta Crystallogr D Struct Biol (2019) 75, 56-69. PubMed Europe PubMed DOI S
Murafuji,H., Muto,T., Goto,M., Imajo,S., Sugawara,H., Oyama,Y., Minamitsuji,Y., Miyazaki,S., Murai,K. and Fujioka,H. Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors Bioorg Med Chem Lett (2019) 29, 334-338. PubMed Europe PubMed DOI I
Silva,L.M., Kryza,T., Stoll,T., Hoogland,C., Dong,Y., Stephens,C.R., Hastie,M.L., Magdolen,V., Kleifeld,O., Gorman,J.J. and Clements,J.A. Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome Mol Cell Proteomics (2019) 18, 818-836. PubMed Europe PubMed DOI P

2018

Al-Awadhi,F.H., Gao,B., Rezaei,M.A., Kwan,J.C., Li,C., Ye,T., Paul,V.J. and Luesch,H. Discovery, synthesis, pharmacological profiling, and biological characterization of brintonamides A-E, novel dual protease and GPCR modulators from a marine cyanobacterium J Med Chem (2018) 61, 6364-6378. PubMed Europe PubMed DOI I
Du,J.P., Li,L., Zheng,J., Zhang,D., Liu,W., Zheng,W.H., Li,X.S., Yao,R.C., Wang,F., Liu,S. and Tan,X. Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer Oncotarget (2018) 9, 12894-12906. PubMed Europe PubMed DOI PMC EPMC K T
Horn,M., Zbodakova,O., Kasparek,P., Srp,J., Haneckova,R., Hradilek,M., Mares,M. and Sedlacek,R. Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models Biol Chem (2018) 399, 1085-1089. PubMed Europe PubMed DOI A
Kidana,K., Tatebe,T., Ito,K., Hara,N., Kakita,A., Saito,T., Takatori,S., Ouchi,Y., Ikeuchi,T., Makino,M., Saido,T.C., Akishita,M., Iwatsubo,T., Hori,Y. and Tomita,T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice EMBO Mol Med (2018) 10, e8184-e8184. PubMed Europe PubMed DOI K
Murafuji,H., Sakai,H., Goto,M., Oyama,Y., Imajo,S., Sugawara,H., Tomoo,T. and Muto,T. Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors Bioorg Med Chem Lett (2018) 28, 1371-1375. PubMed Europe PubMed DOI I
Murafuji,H., Sugawara,H., Goto,M., Oyama,Y., Sakai,H., Imajo,S., Tomoo,T. and Muto,T. Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones Bioorg Med Chem (2018) 26, 3639-3653. PubMed Europe PubMed DOI S I
Zieger,K., Weiner,J., Kunath,A., Gericke,M., Krause,K., Kern,M., Stumvoll,M., Kloting,N., Bluher,M. and Heiker,J.T. Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo Cell Mol Life Sci (2018) 75, 727-742. PubMed Europe PubMed DOI K

2017

Adamopoulos,P.G., Kontos,C.K. and Scorilas,A. Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing Sci Rep (2017) 7, 17299-17299. PubMed Europe PubMed DOI PMC EPMC M
de Veer,S.J., Furio,L., Swedberg,J.E., Munro,C.A., Brattsand,M., Clements,J.A., Hovnanian,A. and Harris,J.M. Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum J Invest Dermatol (2017) 137, 430-439. PubMed Europe PubMed DOI
Igawa,S., Kishibe,M., Minami-Hori,M., Honma,M., Tsujimura,H., Ishikawa,J., Fujimura,T., Murakami,M. and Ishida-Yamamoto,A. Incomplete KLK7 secretion and upregulated LEKTI expression underlie hyperkeratotic stratum corneum in atopic dermatitis J Invest Dermatol (2017) 137, 449-456. PubMed Europe PubMed DOI
Kasparek,P., Ileninova,Z., Zbodakova,O., Kanchev,I., Benada,O., Chalupsky,K., Brattsand,M., Beck,I.M. and Sedlacek,R. KLK5 and KLK7 ablation fully rescues lethality of Netherton syndrome-like phenotype PLoS Genet (2017) 13, e1006566-e1006566. PubMed Europe PubMed DOI K
McGovern,J.A., Meinert,C., deVeer,S.J., Hollier,B.G., Parker,T.J. and Upton,Z. Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models Br J Dermatol (2017) 176, 145-158. PubMed Europe PubMed DOI
Murafuji,H., Sakai,H., Goto,M., Imajo,S., Sugawara,H. and Muto,T. Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors Bioorg Med Chem Lett (2017) 27, 5272-5276. PubMed Europe PubMed DOI I
Silva,L.M., Stoll,T., Kryza,T., Stephens,C.R., Hastie,M.L., Irving-Rodgers,H.F., Dong,Y., Gorman,J.J. and Clements,J.A. Mass spectrometry-based determination of kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency Sci Rep (2017) 7, 6789-6789. PubMed Europe PubMed DOI PMC EPMC P
Zheng,X., He,M., Tan,X., Zheng,J., Wang,F. and Liu,S. 3D-Quantitative structure-activity relationship and docking studies of coumarin derivatives as tissue kallikrein 7 inhibitors J Pharm Pharmacol (2017) 69, 1136-1144. PubMed Europe PubMed DOI I

2016

Chen,W., Kinsler,V.A., Macmillan,D. and Di,W.L. Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - a potential therapeutic intervention for skin diseases PLoS ONE (2016) 11, e0166268-e0166268. PubMed Europe PubMed DOI PMC EPMC
Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P. Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays Mol Cell Proteomics (2016) 15, 2863-2876. PubMed Europe PubMed DOI A
Maibaum,J., Liao,S.M., Vulpetti,A., Ostermann,N., Randl,S., Rudisser,S., Lorthiois,E., Erbel,P., Kinzel,B., Kolb,F.A., Barbieri,S., Wagner,J., Durand,C., Fettis,K., Dussauge,S., Hughes,N., Delgado,O., Hommel,U., Gould,T., Mac Sweeney,A., Gerhartz,B., Cumin,F., Flohr,S., Schubart,A., Jaffee,B., Harrison,R., Risitano,A.M., Eder,J. and Anderson,K. Small-molecule factor D inhibitors targeting the alternative complement pathway Nat Chem Biol (2016) 12, 1105-1110. PubMed Europe PubMed DOI I

2015

Arama,D.P., Soualmia,F., Lisowski,V., Longevial,J.F., Bosc,E., Maillard,L.T., Martinez,J., Masurier,N. and El Amri,C. Pyrido-imidazodiazepinones as a new class of reversible inhibitors of human kallikrein 7 Eur J Med Chem (2015) 93C, 202-213. PubMed Europe PubMed DOI I
Oliveira,J.R., Bertolin,T.C., Andrade,D., Oliveira,L.C., Kondo,M.Y., Santos,J.A., Blaber,M., Juliano,L., Severino,B., Caliendo,G., Santagada,V. and Juliano,M.A. Specificity studies on kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity Biochim Biophys Acta (2015) 1854, 73-83. PubMed Europe PubMed DOI A
Tan,X., Soualmia,F., Furio,L., Renard,J.F., Kempen,I., Qin,L., Pagano,M., Pirotte,B., El Amri,C., Hovnanian,A. and Reboud-Ravaux,M. Toward the first class of suicide inhibitors of kallikreins involved in skin diseases J Med Chem (2015) 58, 598-612. PubMed Europe PubMed DOI I
Yu,Y., Prassas,I., Dimitromanolakis,A. and Diamandis,E.P. Novel biological substrates of human kallikrein 7 identified through degradomics J Biol Chem (2015) 290, 17762-17775. PubMed Europe PubMed DOI P

2014

Shropshire,T.D., Reifert,J., Rajagopalan,S., Baker,D., Feinstein,S.C. and Daugherty,P.S. Amyloid beta peptide cleavage by kallikrein 7 attenuates fibril growth and rescues neurons from Abeta-mediated toxicity in vitro Biol Chem (2014) 395, 109-118. PubMed Europe PubMed DOI P

2013

de Veer,S.J., Ukolova,S.S., Munro,C.A., Swedberg,J.E., Buckle,A.M. and Harris,J.M. Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1 Biopolymers (2013) 100, 510-518. PubMed Europe PubMed DOI
Heiker,J.T., Kloting,N., Kovacs,P., Kuettner,E.B., Strater,N., Schultz,S., Kern,M., Stumvoll,M., Bluher,M. and Beck-Sickinger,A.G. Vaspin inhibits kallikrein 7 by serpin mechanism Cell Mol Life Sci (2013) 70, 2569-2583. PubMed Europe PubMed DOI S
Lundwall,A. Old genes and new genes: The evolution of the kallikrein locus Thromb Haemost (2013) 110, 469-475. PubMed Europe PubMed DOI V
Schultz,S., Saalbach,A., Heiker,J.T., Meier,R., Zellmann,T., Simon,J.C. and Beck-Sickinger,A.G. Proteolytic activation of prochemerin by kallikrein 7 breaks an ionic linkage and results in C-terminal rearrangement Biochem J (2013) 452, 271-280. PubMed Europe PubMed DOI
Tan,X., Furio,L., Reboud-Ravaux,M., Villoutreix,B.O., Hovnanian,A. and El Amri,C. 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases Bioorg Med Chem Lett (2013) 23, 4547-4551. PubMed Europe PubMed DOI I

2012

Britland,S. and Hoyle,M. Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema Biotechnol Prog (2012) 28, 485-489. PubMed Europe PubMed DOI
Clements,J.A., Hooper,J.D. and Dong,Y. The human tissue kallikrein and kallikrein-related peptidase family [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
Farady,C.J., Mayr,L.M. and Kolb,F.A. Kallikrein-related peptidase 7 [ISSN:978-0-12-407742-3] (2012) 3, 2788-2792. DOI
Yamamoto,M., Miyai,M., Matsumoto,Y., Tsuboi,R. and Hibino,T. Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form J Biol Chem (2012) 287, 32825-32834. PubMed Europe PubMed DOI

2011

Ramani,V.C., Kaushal,G.P. and Haun,R.S. Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains Biochim Biophys Acta (2011) 1813, 1525-1531. PubMed Europe PubMed DOI
Teixeira,T.S., Freitas,R.F., Abrahao,O., Jr., Devienne,K.F., de Souza,L.R., Blaber,S.I., Blaber,M., Kondo,M.Y., Juliano,M.A., Juliano,L. and Puzer,L. Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7 Bioorg Med Chem Lett (2011) 21, 6112-6115. PubMed Europe PubMed DOI I

2010

Angelopoulou,K. and Karagiannis,G.S. Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer Mamm Genome (2010) 21, 516-524. PubMed Europe PubMed DOI
Mo,L., Zhang,J., Shi,J., Xuan,Q., Yang,X., Qin,M., Lee,C., Klocker,H., Li,Q.Q. and Mo,Z. Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression Anticancer Res (2010) 30, 3413-3420. PubMed Europe PubMed

2009

Doering,K., Meder,G., Hinnenberger,M., Woelcke,J., Mayr,L.M. and Hassiepen,U. A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 J Biomol Screen (2009) 14, 1-9. PubMed Europe PubMed DOI A
Talieri,M., Mathioudaki,K., Prezas,P., Alexopoulou,D.K., Diamandis,E.P., Xynopoulos,D., Ardavanis,A., Arnogiannaki,N. and Scorilas,A. Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer Thromb Haemost (2009) 101, 741-747. PubMed Europe PubMed DOI

2008

Clements,J.A. Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades? Biol Chem (2008) 389, 1447-1454. PubMed Europe PubMed DOI V
Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 Biol Chem (2008) 389, 623-632. PubMed Europe PubMed DOI P S
Dong,Y., Matigian,N., Harvey,T.J., Samaratunga,H., Hooper,J.D. and Clements,J.A. Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function Biol Chem (2008) 389, 99-109. PubMed Europe PubMed DOI
Psyrri,A., Kountourakis,P., Scorilas,A., Markakis,S., Camp,R., Kowalski,D., Diamandis,E.P. and Dimopoulos,M.A. Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression Ann Oncol (2008) 19, 1271-1277. PubMed Europe PubMed DOI
Ramani,V.C., Hennings,L. and Haun,R.S. Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer BMC Cancer (2008) 8, 373-373. PubMed Europe PubMed DOI PMC EPMC

2007

Debela,M., Hess,P., Magdolen,V., Schechter,N.M., Steiner,T., Huber,R., Bode,W. and Goettig,P. Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7 Proc Natl Acad Sci U S A (2007) 104, 16086-16091. PubMed Europe PubMed DOI PMC EPMC S
Deraison,C., Bonnart,C., Lopez,F., Besson,C., Robinson,R., Jayakumar,A., Wagberg,F., Brattsand,M., Hachem,J.P., Leonardsson,G. and Hovnanian,A. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction Mol Biol Cell (2007) 18, 3607-3619. PubMed Europe PubMed DOI PMC EPMC
Fernandez,I.S., Standker,L., Forssmann,W.G., Gimenez-Gallego,G. and Romero,A. Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family Acta Crystallograph Sect F Struct Biol Cryst Commun (2007) 63, 669-672. PubMed Europe PubMed DOI PMC EPMC
Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U. Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis Genomics (2007) 89, 429-438. PubMed Europe PubMed DOI
Johnson,S.K., Ramani,V.C., Hennings,L. and Haun,R.S. Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin Cancer (2007) 109, 1811-1820. PubMed Europe PubMed DOI
Shaw,J.L. and Diamandis,E.P. Distribution of 15 human kallikreins in tissues and biological fluids Clin Chem (2007) 53, 1423-1432. PubMed Europe PubMed DOI
Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M. Activation profiles and regulatory cascades of the human kallikrein-related peptidases J Biol Chem (2007) 282, 31852-31864. PubMed Europe PubMed DOI V
Zakabunin,A.I., Mishukova,O.V., Khrapov,E.A., Sergeichev,D.S., Boiarskikh,U.A., Sverdlov,E.D. and Filipenko,M.L. [Cloning and expression of the gene of chymotrypsin-like protease of human kallikrein-7 in Escherichia coli and isolation of recombinant protein] Mol Gen Mikrobiol Virusol (2007) 2007, 21-25. PubMed Europe PubMed

2006

[YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences J Biol Chem (1-6-2006) 281, 25678-25688. PubMed Europe PubMed DOI P
[YEAR:20-4-2006]Holzscheiter,L., Biermann,J.C., Kotzsch,M., Prezas,P., Farthmann,J., Baretton,G., Luther,T., Tjan-Heijnen,V.C., Talieri,M., Schmitt,M., Sweep,F.C., Span,P.N. and Magdolen,V. Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer Clin Chem (20-4-2006) 52, 1070-1079. PubMed Europe PubMed DOI
Luo,L.Y. and Jiang,W. Inhibition profiles of human tissue kallikreins by serine protease inhibitors Biol Chem (2006) 387, 813-816. PubMed Europe PubMed DOI
Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V. Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells Biol Chem (2006) 387, 807-811. PubMed Europe PubMed DOI
Stenshamn,K., Bongcam-Rudloff,E., Salmon Hillbertz,N., Nodtvedt,A., Bergvall,K., Hedhammar,A. and Andersson,G. Evaluation of kallikrein 7 as a disease-causing gene for canine atopic dermatitis using microsatellite-based association mapping Anim Genet (2006) 37, 601-603. PubMed Europe PubMed DOI

2005

[YEAR:1-5-2005]Bondurant,K.L., Crew,M.D., Santin,A.D., O'Brien,T.J. and Cannon,M.J. Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzyme Clin Cancer Res (1-5-2005) 11, 3446-3454. PubMed Europe PubMed DOI
Egelrud,T., Brattsand,M., Kreutzmann,P., Walden,M., Vitzithum,K., Marx,U.C., Forssmann,W.G. and Magert,H.J. hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6 Br J Dermatol (2005) 153, 1200-1203. PubMed Europe PubMed DOI P
[YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P. A survey of alternative transcripts of human tissue kallikrein genes Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed Europe PubMed DOI R
Schechter,N.M., Choi,E.J., Wang,Z.M., Hanakawa,Y., Stanley,J.R., Kang,Y., Clayman,G.L. and Jayakumar,A. Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI) Biol Chem (2005) 386, 1173-1184. PubMed Europe PubMed DOI

2004

Caubet,C., Jonca,N., Brattsand,M., Guerrin,M., Bernard,D., Schmidt,R., Egelrud,T., Simon,M. and Serre,G. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7 J Invest Dermatol (2004) 122, 1235-1244. PubMed Europe PubMed DOI
Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y. The tissue kallikrein gene cluster [ISSN:0-12-079610-4] (2004) 2, 1569-1577. V
Egelrud,T. Stratum corneum chymotryptic enzyme [ISSN:0-12-079610-4] (2004) 2, 1556-1558. V
[YEAR:5-2-2004]Kishi,T., Soosaipillai,A., Grass,L., Little,S.P., Johnstone,E.M. and Diamandis,E.P. Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids Clin Chem (5-2-2004) 50, 709-716. PubMed Europe PubMed DOI A
Ny,A. and Egelrud,T. Epidermal hyperproliferation and decreased skin barrier function in mice overexpressing stratum corneum chymotryptic enzyme Acta Derm Venereol (2004) 84, 18-22. PubMed Europe PubMed DOI
Santin,A.D., Cane',S., Bellone,S., Bignotti,E., Palmieri,M., De Las Casas,L.E., Roman,J.J., Anfossi,S., O'Brien,T. and Pecorelli,S. The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells Gynecol Oncol (2004) 94, 283-288. PubMed Europe PubMed DOI
Talieri,M., Diamandis,E.P., Gourgiotis,D., Mathioudaki,K. and Scorilas,A. Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma Thromb Haemost (2004) 91, 180-186. PubMed Europe PubMed DOI
Vasilopoulos,Y., Cork,M.J., Murphy,R., Williams,H.C., Robinson,D.A., Duff,G.W., Ward,S.J. and Tazi-Ahnini,R. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis J Invest Dermatol (2004) 123, 62-66. PubMed Europe PubMed DOI M

2003

Kyriakopoulou,L.G., Yousef,G.M., Scorilas,A., Katsaros,D., Massobrio,M., Fracchioli,S. and Diamandis,E.P. Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer Clin Biochem (2003) 36, 135-143. PubMed Europe PubMed DOI
Ny,A. and Egelrud,T. Transgenic mice over-expressing a serine protease in the skin: evidence of interferon gamma-independent MHC II expression by epidermal keratinocytes Acta Derm Venereol (2003) 83, 322-327. PubMed Europe PubMed DOI
[YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P. Parallel overexpression of seven kallikrein genes in ovarian cancer Cancer Res (1-5-2003) 63, 2223-2227. PubMed Europe PubMed

2002

Hansson,L., Backman,A., Ny,A., Edlund,M., Ekholm,E., Ekstrand Hammarstrom,B., Tornell,J., Wallbrandt,P., Wennbo,H. and Egelrud,T. Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis J Invest Dermatol (2002) 118, 444-449. PubMed Europe PubMed DOI

2001

Clements,J., Hooper,J., Dong,Y. and Harvey,T. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions Biol Chem (2001) 382, 5-14. PubMed Europe PubMed DOI V

2000

Egelrud,T. Desquamation in the stratum corneum Acta Derm Venereol Suppl (Stockh) (2000) 208, 44-45. PubMed Europe PubMed
[YEAR:22-8-2000]Yousef,G.M., Scorilas,A., Magklara,A., Soosaipillai,A. and Diamandis,E.P. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation Gene (22-8-2000) 254, 119-128. PubMed Europe PubMed DOI

1999

Backman,A., Stranden,P., Brattsand,M., Hansson,L. and Egelrud,T. Molecular cloning and tissue expression of the murine analog to human stratum corneum chymotryptic enzyme J Invest Dermatol (1999) 113, 152-155. PubMed Europe PubMed DOI
[YEAR:15-11-1999]Tanimoto,H., Underwood,L.J., Shigemasa,K., Yan Yan,M.S., Clarke,J., Parmley,T.H. and O'Brien,T.J. The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells Cancer (15-11-1999) 86, 2074-2082. PubMed Europe PubMed DOI

1998

Ekholm,E., Sondell,B., Stranden,P., Brattsand,M. and Egelrud,T. Expression of stratum corneum chymotryptic enzyme in human sebaceous follicles Acta Derm Venereol (1998) 78, 343-347. PubMed Europe PubMed
Ekholm,E. and Egelrud,T. The expression of stratum corneum chymotryptic enzyme in human anagen hair follicles: further evidence for its involvement in desquamation-like processes Br J Dermatol (1998) 139, 585-590. PubMed Europe PubMed DOI

1997

Presland,R.B., Kimball,J.R., Kautsky,M.B., Lewis,S.P., Lo,C.Y. and Dale,B.A. Evidence for specific proteolytic cleavage of the N-terminal domain of human profilaggrin during epidermal differentiation J Invest Dermatol (1997) 108, 170-178. PubMed Europe PubMed

1996

Franzke,C.W., Baici,A., Bartels,J., Christophers,E. and Wiedow,O. Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation J Biol Chem (1996) 271, 21886-21890. PubMed Europe PubMed DOI
Sondell,B., Dyberg,P., Anneroth,G.K., Ostman,P.O. and Egelrud,T. Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa Acta Derm Venereol (1996) 76, 177-181. PubMed Europe PubMed

1995

Resing,K.A., Thulin,C., Whiting,K., al-Alawi,N. and Mostad,S. Characterization of profilaggrin endoproteinase 1. A regulated cytoplasmic endoproteinase of epidermis J Biol Chem (1995) 270, 28193-28198. PubMed Europe PubMed DOI
Skytt,A., Stromqvist,M. and Egelrud,T. Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme Biochem Biophys Res Commun (1995) 211, 586-589. PubMed Europe PubMed DOI
Sondell,B., Thornell,L.E. and Egelrud,T. Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies J Invest Dermatol (1995) 104, 819-823. PubMed Europe PubMed

1994

Hansson,L., Stromqvist,M., Backman,A., Wallbrandt,P., Carlstein,A. and Egelrud,T. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase J Biol Chem (1994) 269, 19420-19426. PubMed Europe PubMed
Sondell,B., Thornell,L.E., Stigbrand,T. and Egelrud,T. Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia J Histochem Cytochem (1994) 42, 459-465. PubMed Europe PubMed

1993

Egelrud,T., Regnier,M., Sondell,B., Shroot,B. and Schmidt,R. Expression of stratum corneum chymotryptic enzyme in reconstructed human epidermis and its suppression by retinoic acid Acta Derm Venereol (1993) 73, 181-184. PubMed Europe PubMed
Egelrud,T. Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation J Invest Dermatol (1993) 101, 200-204. PubMed Europe PubMed

1991

Lundstrom,A. and Egelrud,T. Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation Acta Derm Venereol (1991) 71, 471-474. PubMed Europe PubMed

1990

Lundstrom,A. and Egelrud,T. Cell shedding from human plantar skin in vitro: evidence that two different types of protein structures are degraded by a chymotrypsin-like enzyme Arch Dermatol Res (1990) 282, 234-237. PubMed Europe PubMed DOI