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Substrates for peptidase S01.216: coagulation factor Xa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-VMIAALPRTMFI-EDDnp Abz-Val-Met-Ile-Ala-Ala-Leu-Pro-Arg+Thr-Met-Phe-Ile-Glu-Asp-Aspnp S Ala Leu Pro Arg Thr Met Phe Ile Andrade et al., 2003
Abz-VMIAALPRTVFI-EDDnp Abz-Val-Met-Ile-Ala-Ala-Leu-Pro-Arg+Thr-Val-Phe-Ile-Glu-Asp-Aspnp S Ala Leu Pro Arg Thr Val Phe Ile Andrade et al., 2003
Abz-VVIAALPRTMFI-EDDnp Abz-Val-Val-Ile-Ala-Ala-Leu-Pro-Arg+Thr-Met-Phe-Ile-Glu-Asp-Aspnp S Ala Leu Pro Arg Thr Met Phe Ile Andrade et al., 2003
Ac-Ala-Glu-Phe-Arg-ACC Ac-Ala-Glu-Phe-Arg+ACC S Ala Glu Phe Arg ACC - - - Gosalia et al., 2005
Ac-Ala-Gly-Phe-Lys-ACC Ac-Ala-Gly-Phe-Lys+ACC S Ala Gly Phe Lys ACC - - - Gosalia et al., 2005
Ac-Ala-Leu-Phe-Lys-ACC Ac-Ala-Leu-Phe-Lys+ACC S Ala Leu Phe Lys ACC - - - Gosalia et al., 2005
Ac-Ala-Phe-Gly-Arg-ACC Ac-Ala-Phe-Gly-Arg+ACC S Ala Phe Gly Arg ACC - - - Gosalia et al., 2005
Ac-Ala-Phe-Gly-Lys-ACC Ac-Ala-Phe-Gly-Lys+ACC S Ala Phe Gly Lys ACC - - - Gosalia et al., 2005
Ac-Ala-Phe-Phe-Arg-ACC Ac-Ala-Phe-Phe-Arg+ACC S Ala Phe Phe Arg ACC - - - Gosalia et al., 2005
Ac-Ala-Phe-Phe-Lys-ACC Ac-Ala-Phe-Phe-Lys+ACC S Ala Phe Phe Lys ACC - - - Gosalia et al., 2005
Ac-Phe-Phe-Gly-Arg-ACC Ac-Phe-Phe-Gly-Arg+ACC S Phe Phe Gly Arg ACC - - - Gosalia et al., 2005
Ac-Phe-Phe-Phe-Arg-ACC Ac-Phe-Phe-Phe-Arg+ACC S Phe Phe Phe Arg ACC - - - Gosalia et al., 2005
Ac-Phe-Phe-Phe-Lys-ACC Ac-Phe-Phe-Phe-Lys+ACC S Phe Phe Phe Lys ACC - - - Gosalia et al., 2005
Amyloid beta A4 protein P05067-4 18-770 peptide-Arg102+Lys-peptide P - Lys Arg Gly Arg Lys Gln Cys Lys Haas et al., 1997
Amyloid beta A4 protein P05067-4 18-770 peptide-Arg268+Thr-peptide P - Ala Thr Glu Arg Thr Thr Ser Ile Haas et al., 1997
Amyloid beta A4 protein P05067-4 18-770 peptide-Arg510+Ile-peptide P - Ser Glu Pro Arg Ile Ser Tyr Gly Haas et al., 1997
Amyloid beta A4 protein P05067-4 18-770 peptide-Arg573+Gly-peptide P - Ala Ala Asp Arg Gly Leu Thr Thr Haas et al., 1997
Amyloid beta A4 protein P05067-4 18-770 peptide-Arg601+His-peptide P - Ala Glu Phe Arg His Asp Ser Gly Haas et al., 1997
beta-2-glycoprotein 1 P02749 20-345 peptide-Lys336+Thr-peptide P Ala Phe Trp Lys Thr Asp Ala Ser Ohkura et al., 1998 3627
Bz-Ile-Glu-Gly-Arg-NHPhNO2 Bz-Ile-Glu-Gly-Arg+NHPhNO2 S Ile Glu Gly Arg NAN - - -
CBS 31.39 methane-sulfonyl-D-Leu-Gly-Arg+NHPhNO2 S MeS DLe Gly Arg NAN - - - Brown et al., 2004
CH3SO2-D-Leu-Gly-Arg-NHPhNO2 CH3SO2-D-Leu-Gly-Arg+NHPhNO2 S - DLe Gly Arg NAN - - - Tans et al., 1985
coagulation factor V P12259 29-2224 peptide-Arg1793+Leu-peptide P Ser Ser Trp Arg Leu Thr Ser Ser Thorelli et al., 1997 21166
coagulation factor V P12259 29-2224 peptide-Arg1573+Ser-peptide P Trp Tyr Leu Arg Ser Asn Asn Gly Thorelli et al., 1997 21168
coagulation factor V P12259 29-2224 peptide-Arg1046+Thr-peptide P Leu Ser Pro Arg Thr Phe His Pro Thorelli et al., 1997 21169
coagulation factor V P12259 29-2224 peptide-Arg737+Ser-peptide P Leu Gly Ile Arg Ser Phe Arg Asn Thorelli et al., 1997 21170
coagulation factor VII P08709 21-466 peptide-Arg194+Ile-peptide P Pro Gln Gly Arg Ile Val Gly Gly 17374
coagulation factor VII P22457 41-447 peptide-Arg192+Ile-peptide P Pro Gln Gly Arg Ile Val Gly Gly Brandstetter et al., 1996
coagulation factor VII P98139 40-444 peptide-Arg191+Ile-peptide P Pro Gln Gly Arg Ile Val Gly Gly Brandstetter et al., 1996
coagulation factor VIII P00451 20-2351 peptide-Arg1689+Ser-peptide P Gln Ser Pro Arg Ser Phe Gln Lys Nogami et al. 2003
coagulation factor VIII P00451 20-2351 peptide-Arg372+Ser-peptide P Ile Gln Ile Arg Ser Val Ala Lys Nogami et al. 2003
coagulation factor VIII P00451 20-2351 peptide-Arg740+Ser-peptide P Ile Glu Pro Arg Ser Phe Ser Gln Nogami et al. 2003
coagulation factor VIII P00451 20-372 peptide-Lys55+Ser-peptide P Arg Val Pro Lys Ser Phe Pro Phe Nogami et al., 2003
coagulation factor VIII P00451 20-372 peptide-Arg355+Met-peptide P Pro Gln Leu Arg Met Lys Asn Asn Nogami et al., 2003
coagulation factor X P00742 41-179; 183-488 peptide-Arg372+Gln-peptide P Glu Lys Gly Arg Gln Ser Thr Arg Brandstetter et al., 1996
coagulation factor X P00743 41-180; 183-492 peptide-Arg371+-peptide P Glu Lys Gly Arg Leu Ser Ser Thr Brandstetter et al., 1996
coagulation factor X P25155 41-180; 186-475 peptide-Arg378+Leu-peptide P Glu Ala Gly Arg Leu Ser Lys Arg Brandstetter et al., 1996
Hepatocyte growth factor P14210 32-728 Peptide-Arg134+Ser-Peptide P NT Gly Lys Gly Arg Ser Tyr Lys Gly Pediaditakis et al., 2002
Proteinase-activated receptor 1 P25116 38-60 Peptide-Arg41+Ser-Peptide N NT Leu Asp Pro Arg Ser Phe Leu Leu Parry et al., 1996
S-2222 Bz-Ile-Glu-Gly-Arg+NHPhNO2 S Ile Glu Gly Arg NAN - - - Amarant et al., 1991
S2337 Bz-Ile-Glu(piperidine amide)-Gly-Arg+NHPhNO2 S Ile GPA Gly Arg NAN - - - Brown et al., 2004
Spectrozyme XA methoxycarbonyl-cyclo-hexylGlyl-Gly-Arg+NHPhNO2 S - MCH Gly Arg NAN - - - Brown et al., 2004
Thrombin inhibitor madanin 1 Q86FP9 20-79 peptide-Arg44+Thr-peptide P MS Val Gln Lys Arg Thr Asp Gly Asp Figueiredo et al., 2013
Thrombin inhibitor madanin 1 Q86FP9 20-79 peptide-Arg35+Ala-peptide P MS Glu Gln Glu Arg Ala Leu His Val Figueiredo et al., 2013
Thrombin inhibitor madanin 2 Q86FP8 20-80 peptide-Arg44+Tyr-peptide P MS Val Gln Glu Arg Tyr Gln Gly Asn Figueiredo et al., 2013
Thrombin inhibitor madanin 2 Q86FP8 20-80 peptide-Arg35+Ala-peptide P MS Glu Lys Glu Arg Ala Leu Leu Val Figueiredo et al., 2013
thrombin precursor P00735 44-625 peptide-Arg323+Ile-peptide P Ile Glu Gly Arg Ile Val Glu Gly Rosing, 2004 17376
thrombin precursor P00735 44-625 peptide-Arg274+Thr-peptide P Ile Glu Gly Arg Thr Ser Glu Asp Rosing, 2004 17375
thrombin precursor P00734 44-622 peptide-Arg320+Ile-peptide P Ile Asp Gly Arg Ile Val Glu Gly Rosing, 2004
thrombin precursor P00734 44-622 peptide-Arg271+Thr-peptide P Phe Asn Pro Arg Thr Phe Gly Ser 17377
thrombin precursor P19221 25-618 peptide-Lys324+Thr-peptide N Phe Asn Glu Lys Thr Phe Gly Leu 17382
thrombin precursor P19221 25-618 peptide-Arg360+Ile-peptide N Ile Asp Gly Arg Ile Val Glu Gly
thrombin precursor P18292 25-617 peptide-Arg323+Thr-peptide N Phe Asp Glu Arg Thr Phe Gly Leu 17379
thrombin precursor P18292 25-617 peptide-Arg359+Ile-peptide N Ile Asp Gly Arg Ile Val Glu Gly Orcutt et al., 2004 17378
thrombin precursor P00734 44-622 peptide-Arg314+Thr-peptide P Ile Glu Gly Arg Thr Ala Thr Ser Brandstetter et al., 1996 3626
thrombin precursor P19221 44-618 peptide-Arg108+Cys-peptide P Leu Glu Gly Arg Cys Ala Met Asp Brandstetter et al., 1996
thrombin precursor P18292 44-617 peptide-Arg108+Cys-peptide P Leu Glu Gly Arg Cys Ala Met Asp Brandstetter et al., 1996
thrombin precursor Q91001 1-607 peptide-Arg350+Val-peptide P Met Gly Gly Arg Val Val His Gly Brandstetter et al., 1996
thrombin precursor Q91001 1-607 peptide-Arg301+Thr-peptide P Ile Ala Gly Arg Thr Ile Phe Gln Brandstetter et al., 1996
thrombin precursor Q90504 1-628 peptide-Arg368+Val-peptide P Tyr Asp Gly Arg Val Val His Gly Brandstetter et al., 1996
thrombin precursor Q90504 1-628 peptide-Arg319+Ser-peptide P Leu Ser Gly Arg Ser Glu Gly Ala Brandstetter et al., 1996
Trypanothione synthetase Q5DM89 1-652 peptide-Arg556+Asn-peptide P NT Arg Val Gly Arg Asn Val Thr Ile Comini et al., 2005
vitamin K-dependent protein S P07225 42-676 peptide-Arg101+Gln-peptide P Thr Ala Ala Arg Gln Ser Thr Asn Heeb & Griffin, 2002 3625

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