Substrates for peptidase S01.218: protein C (activated)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
coagulation factor V	P12259	29-2224	peptide-Arg334+Asn-peptide	P		Lys	Lys	Thr	Arg	Asn	Leu	Lys	Lys		3527
coagulation factor V	P12259	29-2224	peptide-Arg534+Gly-peptide	P		Leu	Asp	Arg	Arg	Gly	Ile	Gln	Arg		3528
coagulation factor V	P12259	29-2224	peptide-Arg707+Lys-peptide	P		Met	Ala	Thr	Arg	Lys	Met	His	Asp		3525
coagulation factor V	P12259	29-2224	peptide-Lys1022+Ser-peptide	P		Arg	Leu	Lys	Lys	Ser	Gln	Phe	Leu	Kalafatis et al., 1994	3529
coagulation factor VIII	P00451	20-372	peptide-Arg355+Met-peptide	P		Pro	Gln	Leu	Arg	Met	Lys	Asn	Asn	Nogami et al., 2003
D-Phe-Pip-Arg-NHPhNO2			D-Phe-Pip-Arg+NHPhNO2	S		-	DPh	Pip	Arg	NAN	-	-	-	Shen & Dahlbach, 2004
F5 coagulation factor V	O88783	20-2183	peptide-Arg333+Ser-peptide	P		Lys	Lys	Thr	Arg	Ser	Pro	Lys	Thr	Yang et al., 1998	21472
F5 coagulation factor V	O88783	20-2183	peptide-Arg532+Gly-peptide	P		Leu	Asp	Gln	Arg	Gly	Val	Gln	Arg	Yang et al., 1998	21473
Factor VIIIa heavy chain, 200 kDa isoform	P00451	20-1332	peptide-Arg355+Met356-peptide	P		Pro	Gln	Leu	Arg	Met	Lys	Asn	Asn		17410
Factor VIIIa heavy chain, 200 kDa isoform	P00451	20-1332	peptide-Arg562+Gly563-peptide	P		Val	Asp	Gln	Arg	Gly	Asn	Gln	Ile	Fay et al., 1991	17411
Factor VIIIa heavy chain, 200 kDa isoform	P00451	20-1332	peptide-Arg740+Ser741-peptide	P		Ile	Glu	Pro	Arg	Ser	Phe	Ser	Gln	Fay et al., 1991	17412
Glu-Pro-Arg-NHPhNO2			Glu-Pro-Arg-NHPhNO2	S		-	Glu	Pro	Arg	NAN	-	-	-	Shen & Dahlbach, 2004
plasminogen activator inhibitor 1	P05121	24-402	peptide-Arg369+Met-peptide	P	NT	Val	Ser	Ala	Arg	Met	Ala	Pro	Glu	Komissarov et al., 2008
Proteinase-activated receptor 1	P25116	38-60	Peptide-Arg41+Ser-Peptide	N	NT	Leu	Asp	Pro	Arg	Ser	Phe	Leu	Leu	Parry et al., 1996
Spectrozyme PCa			D-Lys(gamma-Z)-Pro-Arg-NHPhNO2	S		-	DLZ	Pro	Arg	NAN	-	-	-	Shen & Dahlbach, 2004