Substrates for peptidase M10.019: matrix metallopeptidase-20

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Abz-Gln-Gly-His-Pro-Pro-Leu-Gln-Gln-Val-Glu-Gly-Pro-Met-Val-Tyr(NO2)			Abz-Gln-Gly-His-Pro-Pro-Leu-Gln+Gln-Val-Glu-Gly-Pro-Met-Val-Tyr(NO2)	S		Pro	Pro	Leu	Gln	Gln	Val	Glu	Gly	Chun et al., 2010
Abz-Gly-Arg-Gly-Gly-Pro-Leu-Ala-Tyr-Gly-Ala-Met-Phe-Pro-Gly-Tyr(NO2)			Abz-Gly-Arg-Gly-Gly-Pro-Leu-Ala+Tyr-Gly-Ala-Met-Phe-Pro-Gly-Tyr(NO2)	S		Gly	Pro	Leu	Ala	Tyr	Gly	Ala	Met	Chun et al., 2010
Abz-Gly-Leu-Ala-Asp-Ala-Tyr-Glu-Thr-Tyr-Gly-Ala-Tyr(NO2)			Abz-Gly-Leu-Ala-Asp-Ala+Tyr-Glu-Thr-Tyr-Gly-Ala-Tyr(NO2)	S		Leu	Ala	Asp	Ala	Tyr	Glu	Thr	Tyr	Chun et al., 2010
Abz-Ser-Gly-Val-Leu-Gly-Gly-Leu-Leu-Ala-Asn-Pro-Lys-Tyr(NO2)			Abz-Ser-Gly-Val-Leu-Gly-Gly+Leu-Leu-Ala-Asn-Pro-Lys-Tyr(NO2)	S		Val	Leu	Gly	Gly	Leu	Leu	Ala	Asn	Chun et al., 2010
Abz-Ser-Leu-Gln-Gly-Leu-Asn-Met-Leu-Ser-Gln-Tyr-Ser-Lys(Dnp)			Abz-Ser-Leu-Gln-Gly-Leu-Asn+Met-Leu-Ser-Gln-Tyr-Ser-Lys(Dnp)	S		Gln	Gly	Leu	Asn	Met	Leu	Ser	Gln	Chun et al., 2010
Abz-Ser-Met-Phe-Pro-Ile-Ala-Arg-Leu-Ile-Ser-Gln-Gly-Pro-Val-Tyr(NO2)			Abz-Ser-Met-Phe-Pro-Ile-Ala-Arg+Leu-Ile-Ser-Gln-Gly-Pro-Val-Tyr(NO2)	S		Pro	Ile	Ala	Arg	Leu	Ile	Ser	Gln	Chun et al., 2010
aggrecan core protein	P16112	17-2415	peptide-Asn360+Phe-peptide	P		Ile	Pro	Glu	Asn	Phe	Phe	Gly	Val	Stracke et al., 2000	18078
ameloblastin	Q28989	27-421	peptide-Pro28+Ala-peptide	P		Ser	Ala	Val	Pro	Ala	Phe	Pro	Arg	Iwata et al., 2007	20091
ameloblastin	Q28989	27-421	peptide-Asn57+Met-peptide	P		Gln	Gly	Leu	Asn	Met	Leu	Ser	Gln	Iwata et al., 2007	20092
ameloblastin	Q28989	27-421	peptide-Gln156+Gln-peptide	P		Pro	Pro	Leu	Gln	Gln	Val	Glu	Gly	Iwata et al., 2007	20093
ameloblastin	Q28989	27-421	peptide-Gln165+Gln-peptide	P		Met	Val	Gln	Gln	Gln	Val	Ala	Pro	Iwata et al., 2007	20094
ameloblastin	Q28989	27-421	peptide-Arg196+Leu-peptide	P		Pro	Ile	Ala	Arg	Leu	Ile	Ser	Gln	Iwata et al., 2007	20095
ameloblastin	Q28989	27-421	peptide-Ala248+Tyr-peptide	P		Gly	Pro	Leu	Ala	Tyr	Gly	Ala	Met	Iwata et al., 2007	20096
ameloblastin	Q28989	27-421	peptide-Gly326+Leu-peptide	P		Val	Leu	Gly	Gly	Leu	Leu	Ala	Asn	Iwata et al., 2007	20097
ameloblastin	Q28989	27-421	peptide-Arg345+Ser-peptide	P		Pro	Ala	Gly	Arg	Ser	Arg	Gly	Pro	Iwata et al., 2007	20098
ameloblastin	Q28989	27-421	peptide-Ala368+Tyr-peptide	P		Leu	Ala	Asp	Ala	Tyr	Glu	Thr	Tyr	Iwata et al., 2007	20099
amelogenin	P45561	17-189	peptide-Ser148+Met-peptide	P		Pro	Met	Phe	Ser	Met	Gln	Ser	Leu		16652
amelogenin	P45561	17-189	peptide-Phe145-Ser-peptide	P		Pro	Pro	Met	Phe	Ser	Met	Gln	Ser		16647
amelogenin	P45561	17-189	peptide-Pro136+Leu-peptide	P		Pro	Ile	Gln	Pro	Leu	Leu	Pro	Gln		16651
amelogenin	P45561	17-189	peptide-Pro107+Ala-peptide	P		Leu	Pro	Leu	Pro	Ala	Gln	Gln	Pro		16650
amelogenin	P45561	17-189	peptide-Ala63+Leu-peptide	P		Gln	Ser	His	Ala	Leu	Gln	Pro	His		16646
amelogenin	P45561	17-189	peptide-Trp45+Leu-peptide	P		Met	Gly	Gly	Trp	Leu	His	His	Gln	Zhu et al., 2008	20128
amelogenin	P45561	17-189	peptide-Pro105+Leu-peptide	P		Pro	Asn	Leu	Pro	Leu	Pro	Ala	Gln		16649
Amelogenin	P45561-1	159-171	peptide-Ser164+Met-peptide	S	MS	Pro	Met	Phe	Ser	Met	Gln	Ser	Leu	Nagano et al., 2009
Amelogenin	P45561-1	169-182	peptide-Pro173+Leu-peptide	S	MS	Pro	Asp	Leu	Pro	Leu	Glu	Ala	Trp	Nagano et al., 2009
Amelogenin	P45561-1	169-182	peptide-Pro178+Ala-peptide	S	MS	Glu	Ala	Trp	Pro	Ala	Thr	Asp	Lys	Nagano et al., 2009
amelogenin, X isoform	Q99217	17-191	peptide-Tyr33+Glu-peptide	P		Asn	Phe	Ser	Tyr	Glu	Val	Leu	Thr	Zhu et al., 2008	20127
amelogenin, X isoform	Q99217	17-191	peptide-Pro163+Met-peptide	P		Pro	Met	Phe	Pro	Met	Gln	Pro	Leu	Zhu et al., 2008	20129
amelogenin, X isoform	Q99217	17-191	peptide-Pro172+Asp-peptide	P		Pro	Met	Leu	Pro	Asp	Leu	Thr	Leu	Zhu et al., 2008	20130
amelogenin, X isoform	Q99217	17-191	peptide-Thr175+Leu-peptide	P		Pro	Asp	Leu	Thr	Leu	Glu	Ala	Trp	Zhu et al., 2008	20131
amelogenin, X isoform	Q99217	17-191	peptide-Leu176+Glu-peptide	P		Asp	Leu	Thr	Leu	Glu	Ala	Trp	Pro	Zhu et al., 2008	20132
amelogenin, X isoform	Q99217	17-191	peptide-Pro180+Ser-peptide	P		Glu	Ala	Trp	Pro	Ser	Thr	Asp	Lys	Zhu et al., 2008	20133
amelogenin, X isoform	Q99217	17-191	peptide-Trp60+Leu-His-His-gln	P		Met	Gly	Gly	Trp	Leu	His	His	Gln	Zhu et al., 2008	18081
Amelogenin, X isoform	P63277-4	17-210	peptide-Pro198+Ala-peptide	P		Glu	Ala	Trp	Pro	Ala	Thr	Asp	Lys	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Pro194+Leu-peptide	P		Pro	Glu	Leu	Pro	Leu	Glu	Ala	Trp	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Phe181+Ser-peptide	P		Pro	Pro	Leu	Phe	Ser	Met	Gln	Pro	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Pro170+Leu-peptide	P		Pro	Met	Gln	Pro	Leu	Ala	Pro	Gln	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Pro167+Met-peptide	P		Pro	Leu	His	Pro	Met	Gln	Pro	Leu	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Ser85+Gln-peptide	P		Pro	Val	Leu	Ser	Gln	Gln	His	Pro	Ryu et al., 1999
Amelogenin, X isoform	P63277-4	17-210	peptide-Trp75+Leu-peptide	P		Met	Gly	Gly	Trp	Leu	His	His	Gln	Ryu et al., 1999	18080
collagen alpha-1(XVIII) chain	P39060	24-1754	peptide-Ser1557+Tyr-peptide	P		His	His	Ser	Ser	Tyr	Val	His	Leu	Heljasvaara et al., 2005	18960
DSPP600	Q6YBV4	1-600	peptide-Arg391+Ser-peptide	P		Ala	Ala	Pro	Arg	Ser	Gly	Asn	Arg	Yamakoshi et al., 2006	20090
laminin subunit gamma-2	Q61092	22-1191	peptide-Ala606+Leu-peptide	P		Asp	His	Ala	Ala	Leu	Thr	Ser	Cys	Piril� et al., 2003	23322