Substrates for peptidase M12.226: ADAMTS8 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Ala734+Leu-peptide	P	MS	Asn	Tyr	Leu	Ala	Leu	Lys	Thr	Ala	Santamaria et al., 2021
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Tyr742+Leu-peptide	P	MS	Asp	Gly	Gln	Tyr	Leu	Leu	Asn	Gly	Santamaria et al., 2021
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Gln789+Leu-peptide	P	MS	Leu	Thr	Val	Gln	Leu	Leu	Thr	Val	Santamaria et al., 2021
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Leu790+Leu-peptide	P	MS	Thr	Val	Gln	Leu	Leu	Thr	Val	Pro	Santamaria et al., 2021
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Met816+Gln-peptide	P	MS	Asp	Phe	Ser	Met	Gln	Ser	Ser	Lys	Santamaria et al., 2021
a disintegrin and metalloproteinase with thrombospondin motifs 8	Q9UP79	214-889	peptide-Ser818+Ser-peptide	P	MS	Ser	Met	Gln	Ser	Ser	Lys	Glu	Arg	Santamaria et al., 2021
Aggrecan core protein	P16112	17-2415	peptide-Glu392+Ala-peptide	P	AB	Thr	Glu	Gly	Glu	Ala	Arg	Gly	Ser	Collins-Racie et al., 2004
osteopontin isoform 2	P10451-4	17-300	peptide-Asn53+Leu-peptide	P	MS	Gln	Lys	Gln	Asn	Leu	Leu	Ala	Pro	Santamaria et al., 2021
osteopontin isoform 2	P10451-4	17-300	peptide-Asp217+Asp-peptide	P	MS	Ser	Gln	Leu	Asp	Asp	Gln	Ser	Ala	Santamaria et al., 2021
osteopontin isoform 2	P10451-4	17-300	peptide-Gln228+Ser-peptide	P	MS	Ser	His	Lys	Gln	Ser	Arg	Leu	Tyr	Santamaria et al., 2021