Substrates for peptidase M12.222: ADAMTS1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
aggrecan core protein	P13608	17-2364	peptide-Glu1871+Leu-peptide	P		Val	Ser	Gln	Glu	Leu	Gly	Gln	Arg		16959
aggrecan core protein	P16112	17-2415	peptide-Asn360+Phe-peptide	P		Ile	Pro	Glu	Asn	Phe	Phe	Gly	Val	Rodgriguez-Manzaneque et al., 2002	4035
aggrecan core protein	P16112	17-2415	peptide-Glu1733+Gly-peptide	P		Lys	Glu	Glu	Glu	Gly	Leu	Gly	Ser	Rodgriguez-Manzaneque et al., 2002	4034
aggrecan core protein	P16112	17-2415	peptide-Glu392+Ala-peptide	P		Thr	Glu	Gly	Glu	Ala	Arg	Gly	Ser	Rodgriguez-Manzaneque et al., 2002
aggrecan core protein	P16112	17-2415	peptide-Glu1564+Gly-peptide	P		Ser	Glu	Leu	Glu	Gly	Arg	Gly	Thr	Rodgriguez-Manzaneque et al., 2002
aggrecan core protein	P16112	17-2415	peptide-Glu1938+Leu-peptide	P		Ile	Ser	Gln	Glu	Leu	Gly	Gln	Arg	Rodgriguez-Manzaneque et al., 2002
Aggrecan core protein	P16112	1817-1843	Peptide-Glu1838+Ala-Peptide	P	CS	Thr	Ala	Gln	Glu	Ala	Gly	Glu	Gly	Sandy et al., 2001
Brevican core protein isoform 1	P55068	373-400	Peptide-Glu395+Ser-Peptide	P	CS	Val	Glu	Ser	Glu	Ser	Arg	Gly	Ala	Sandy et al., 2001
thrombospondin-1	P07996	19-1170	peptide-Glu311+Leu-peptide	P	NT	Leu	Ala	Asn	Glu	Leu	Arg	Arg	Pro	Lee et al., 2006	20158
thrombospondin-2	P35442	19-1172	peptide-Glu306+Leu-peptide	P	NT	Phe	Leu	Trp	Glu	Leu	Ile	Gly	Gly	Lee et al., 2006	20159
versican core protein	P13611	21-3396	peptide-Glu1428+Ala-peptide	P		Glu	Ala	Ala	Glu	Ala	Arg	Arg	Gly	Russell et al., 2003	4033
Versican core protein	P13611	383-410	Peptide-Glu405+Gln-Peptide	P	CS	Val	Ser	Phe	Glu	Gln	Lys	Ala	Thr	Sandy et al., 2001
Versican core protein, Isoform V1	P13611-2	357-567	Peptide-Glu441+Ala-Peptide	P	CS	Glu	Ala	Ala	Glu	Ala	Arg	Arg	Gly	Sandy et al., 2001
Versican core protein, Isoform V1	P13611-2	21-2409	peptide-Glu768+Leu-peptide	P	MS	Leu	Pro	Phe	Glu	Leu	Glu	Ser	Pro	Martin et al., 2021
Versican core protein, Isoform V1	P13611-2	21-2409	peptide-Gln1027+Leu-peptide	P	MS	Ser	Gly	Glu	Gln	Leu	Val	Thr	Val	Martin et al., 2021
Versican core protein, Isoform V1	P13611-2	21-2409	peptide-Glu923+Arg-peptide	P	MS	Val	Ile	Ser	Glu	Arg	Leu	Gly	Glu	Martin et al., 2021