Substrates for peptidase M10.021: matrix metallopeptidase-19

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
aggrecan core protein	P16112	17-2415	peptide-Asn341+Phe-peptide	P		Ile	Pro	Glu	Asn	Phe	Phe	Gly	Val	Sedlacek, 2004	16658
matrix metallopeptidase-9	P14780	20-707	peptide-Lys92+Ala-peptide	P		Ala	Thr	Leu	Lys	Ala	Met	Arg	Thr	Stracke et al., 2000
Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2			Mca-Pro-Leu-Ala+Nva-Dpa-Ala-Arg-NH2	S		Mca	Pro	Leu	Ala	nVa	Dpa	Ala	Arg	Stracke et al., 2000
Nidogen-1	P14543	29-1247	peptide-Thr1238+Leu-peptide	P	-	Pro	Asp	Asn	Thr	Leu	Gly	Val	Asp	Titz et al., 2004
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Thr108+Tyr-peptide	P		Arg	Ala	Val	Thr	Tyr	Ser	Arg	Ser	Andolfo et al., 2002	19933
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Tyr109+Ser-peptide	P		Ala	Val	Thr	Tyr	Ser	Arg	Ser	Arg	Andolfo et al., 2002
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Ser110+Arg-peptide	P		Val	Thr	Tyr	Ser	Arg	Ser	Arg	Tyr	Andolfo et al., 2002
urokinase plasminogen activator surface receptor	Q03405	23-305	peptide-Arg111+Ser-peptide	P		Thr	Tyr	Ser	Arg	Ser	Arg	Tyr	Leu	Andolfo et al., 2002