Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01009

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-418	P	release of a signal peptide		Park et al., 2000
30	peptidase 1 (mite)	25-418	P			Meighan & Pirzad, 2004
34	mesotrypsin	25-418	P			Szepessy & Sahin-Toth, 2006
36	peptidase 1 (mite)	25-418	P			Meighan & Pirzad, 2004
38	unknown peptidase	25-418	N			Cordara et al., 2011
114	BaP1 peptidase (Bothrops asper)	25-418	N		MS	Paes Leme et al., 2010
142	bothropasin	25-418	N		MS	Paes Leme et al., 2010
166	bothropasin	25-418	N		MS	Paes Leme et al., 2010
166	atrolysin C	25-418	N		MS	Paes Leme et al., 2010
166	BaP1 peptidase (Bothrops asper)	25-418	N		MS	Paes Leme et al., 2010
223	matrix metallopeptidase-12	25-418	P			Gronski et al., 1997
223	matrix metallopeptidase-18	25-418	P			Sang & Shi, 2004
232	atrolysin C	25-418	N		MS	Paes Leme et al., 2010
232	BaP1 peptidase (Bothrops asper)	25-418	N		MS	Paes Leme et al., 2010
273	BaP1 peptidase (Bothrops asper)	25-418	N		MS	Paes Leme et al., 2010
274	bothropasin	25-418	N		MS	Paes Leme et al., 2010
290	bothropasin	25-418	N		MS	Paes Leme et al., 2010
290	BaP1 peptidase (Bothrops asper)	25-418	N		MS	Paes Leme et al., 2010
358	unknown peptidase	25-418	N			Cordara et al., 2011
373	glycyl endopeptidase	25-418	N			Mast et al., 1992
374	matrix metallopeptidase-11	25-418	P	release of a bioactive peptide		Pei et al., 1994
374	adamalysin	25-418	N			Kress et al., 1979
375	thermolysin	25-418	N			Chang et al., 1996
376	papain	25-418	N			Mast et al., 1992
376	periodontain	25-418	N			Nelson et al., 1999
376	thermolysin	25-418	N			Chang et al., 1996
376	aureolysin	25-418	N			Potempa & Travis, 2004
376	matrix metallopeptidase-1	25-418	P			Nelson et al., 1998
376	matrix metallopeptidase-8	25-418	P			Knauper et al., 1990
376	matrix metallopeptidase-9	25-418	P	release of a bioactive peptide		Nelson et al., 1998
376	matrix metallopeptidase-7	25-418	P	springing of a trap mechanism		Sires et al., 1994
376	matrix metallopeptidase-12	25-418	P	release of a bioactive peptide		Shapiro et al., 2004
376	membrane-type matrix metallopeptidase-6	25-418	P			Nie & Pei, 2004
376	matrix metallopeptidase-26	25-418	P			Park et al., 2002
378	cathepsin L	25-418	P	normal turnover		Johnson et al., 1986
378	peptidase 1 (mite)	25-418	P	springing of a trap mechanism		Nelson et al., 1998
378	periodontain	25-418	N			Nelson et al., 1999
378	staphopain A	25-418	N			Potempa et al., 1986
378	staphopain C	25-418	N		NT	Wladyka et al., 2011
378	glutamyl endopeptidase I	25-418	P			Potempa et al., 1986
379	peptidase 1 (mite)	25-418	P	springing of a trap mechanism		Nelson et al., 1998
381	pseudolysin	25-418	N			Morihara et al., 1984
381	matrix metallopeptidase-1	25-418	P			Desrochers et al., 1991
381	matrix metallopeptidase-8	25-418	P			Knauper et al., 1990
381	matrix metallopeptidase-9	25-418	P	normal turnover		Nelson et al., 1998
381	matrix metallopeptidase-3	25-418	P	normal turnover		Nelson et al., 1998
381	matrix metallopeptidase-7	25-418	P			<%Nelson et al., 1998[]%>
381	matrix metallopeptidase-12	25-418	P			Banda et al., 1988
381	membrane-type matrix metallopeptidase-6	25-418	P			Nie & Pei, 2004
381	matrix metallopeptidase-26	25-418	P			Park et al., 2002
382	papain	25-418	P			<%Nelson et al., 1998[]%>
382	cathepsin L	25-418	P	normal turnover		Johnson et al., 1986
382	serralysin	25-418	P			Potempa et al., 1986
382	chymotrypsin A (cattle-type)	25-418	N			Chang et al., 1996
382	elastase-2	25-418	P			Nelson et al., 1999
382	granzyme M	25-418	P			Mahrus et al., 2004
382	kallikrein-related peptidase 3	25-418	P			Zhang et al., 1997
382	mesotrypsin	25-418	P			Szepessy & Sahin-Toth, 2006
382	seaprose (Aspergillus melleus)	25-418	P			Nelson et al., 1998
396	matrix metallopeptidase-7	25-418	P			Sires et al., 1994